遗传 ›› 2013, Vol. 35 ›› Issue (7): 856-866.doi: 10.3724/SP.J.1005.2013.00856

• 综述 • 上一篇    下一篇

斑马鱼在再生医学研究中的应用及进展

严丽锋, 顾爱华   

  1. 南京医科大学公共卫生学院, 南京 210029
  • 收稿日期:2013-02-25 修回日期:2013-03-24 出版日期:2013-07-20 发布日期:2013-07-25
  • 通讯作者: 顾爱华 E-mail:aihuagu@njmu.edu.cn
  • 基金资助:

    国家自然科学基金面上项目(编号:81172694)和江苏省大学生创新训练计划重点项目(编号:2012JSSPITP1018)资助

Progress and application of zebrafish in regenerative medicine

YAN Li-Feng, GU Ai-Hua   

  1. School of Public Health, Nanjing Medical University, Nanjing 210029, China
  • Received:2013-02-25 Revised:2013-03-24 Online:2013-07-20 Published:2013-07-25

摘要: 组织器官的再生现象一直以来吸引着众多生物学家们的关注。再生能力在不同物种间差异很大, 与人及高等脊椎动物相比, 低等脊椎动物(如:斑马鱼)有着较高的再生能力。斑马鱼的鳍、心脏、视网膜、视神经、脊髓、肝脏及感觉毛细胞等都具有很强的再生能力。因此, 从斑马鱼再生过程的研究中将获得大量有用的信息, 促进对人类再生能力缺陷的认识, 进而推动再生医学的发展。文章就斑马鱼在心脏、神经系统、肝脏、鳍再生医学研究中的进展及应用做一综述。

关键词: 斑马鱼, 心脏再生, 神经再生, 肝脏再生, 鳍再生

Abstract: The phenomenon of “tissue regeneration” has attracted numerous biologists for many years. Regenerative capacity differs greatly across species. The lower vertebrates such as zebrafish have exceptionally high regeneration abilities, while most high vertebrate species including humans do not have a remarkable ability for regeneration. It has been found zebrafish has a strong ability to regenerate a variety of tissues and organs including fins, heart, retina, optic nerve, spinal cord, liver, and sensory hair cells. Thus, we can learn useful information from the zebrafish regeneration model to understand the human regeneration defects and promote the development of regenerative medicine. This review summarizes the current research status for regeneration of heart, nerve, liver, and fin regeneration in zebrafish.

Key words: zebrafish, heart regeneration, nerve regeneration, liver regeneration, fin regeneration