脂蛋白脂酶调控因子研究进展

doi:10.3724/SP.J.1005.2013.00830

遗传 ›› 2013, Vol. 35 ›› Issue (7): 830-838.doi: 10.3724/SP.J.1005.2013.00830

脂蛋白脂酶调控因子研究进展

姜延志¹, 邢淑华¹, 岑王敏¹, 陈建宁¹, 李学伟²

1. 四川农业大学生命科学与理学院, 雅安 625014 2. 四川农业大学动物科技学院, 雅安 625014

收稿日期:2012-10-25 修回日期:2012-12-21 出版日期:2013-07-20 发布日期:2013-07-25
通讯作者: 李学伟 E-mail:xuewei.li@sicau.edu.cn
基金资助:
四川省教育厅青年基金项目(编号：2010-2013)和农业部国家生猪现代产业技术体系(编号：CARS-36-05B)资助

New insights in regulation factors of lipoprotein lipase

JIANG Yan-Zhi¹, XING Shu-Hua¹, CEN Wang-Min¹, CHEN Jian-Ning¹, LI Xue-Wei²

1. College of Life and Science, Sichuan Agricultural University, Ya’an 625014, China 2. College of Animal Science and Technology, Sichuan Agricultural University, Ya’an 625014, China

Received:2012-10-25 Revised:2012-12-21 Online:2013-07-20 Published:2013-07-25

摘要/Abstract

摘要： 脂蛋白脂酶(Lipoprotein lipase, LPL)是脂质代谢的关键酶, 其正常调控对于机体向组织提供脂质营养至关重要。作为LPL重要的调控因子, 糖基化磷脂酰肌醇锚定高密度脂蛋白结合蛋白1(Glycosylphosphatidylinositol- anchored high density lipoprotein-binding protein 1, GPIHBP1)能与LPL结合起脂解平台的作用, 并作为载体参与LPL向毛细血管内皮细胞的转运。另外, 近年来也鉴定出其他几个LPL活性调控因子, 包括microRNAs、A型重复排序蛋白相关受体(Sortilin-related receptor with A-type repeats, SorLA)和载脂蛋白(Apolipoproteins, apo)。这些LPL调控因子的成功鉴定, 有助于人们深入认识机体脂解代谢和乳糜微粒血症发生的内在机制。文章重点综述了LPL的调控因子GPIHBP1的研究进展, 同时也对其他几个调控因子的研究进展进行了讨论。

关键词: 脂蛋白脂酶, 糖基化磷脂酰肌醇锚定高密度脂蛋白结合蛋白1, 调控因子

Abstract: Lipoprotein lipase (LPL) is an essential enzyme in the lipid metabolism, and proper regulation of LPL is important for controlling the delivery of lipid nutrients to tissues. Recent studies have identified glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1(GPIHBP1) as the important regulation factor of LPL that serves as a binding platform for lipolysis on the vascular lumen and an endothelial cell transporter transporting LPL from the interstitial spaces to the capillary lumen. In addition, several other regulation factors of LPL have also been identified including microRNAs, SorLA (Sortilin-related receptor with A-type repeats), and apolipoproteins that are potentially important for regulating LPL activity. These discoveries provide new directions for understanding basic mechanisms of lipolysis and hyperlipidemia. In this update, we focused on summarizing recent progresses on GPIHBP1, the endothelial cell LPL transporter. We also highlighted the recent progresses on several other regulation factors of LPL that are relevant to the regulation of LPLactivity.

Key words: LPL, GPIHBP1, regulation factors

姜延志邢淑华岑王敏陈建宁李学伟. 脂蛋白脂酶调控因子研究进展[J]. 遗传, 2013, 35(7): 830-838.

JIANG Yan-Zhi XING Shu-Hua CEN Wang-Min CHEN Jian-Ning LI Xue-Wei. New insights in regulation factors of lipoprotein lipase[J]. HEREDITAS, 2013, 35(7): 830-838.

参考文献

[1] Brunzell JD, Deeb SS. Familial lipoprotein lipase deficiency, apo C-II deficiency, and hepatic lipase deficiency. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The metabolic and molecular bases of inherited disease. 8th ed. New York: McGraw-Hill, 2001: 2789-2816.
[2] Olivecrona T, Olivecrona G. The ins and outs of adipose tissue. In: Ehnholm C, ed. Cellular Lipid Metabolism. Springer: Berlin Heidelberg, 2009: 315-369.
[3] Wang H, Eckel RH. Lipoprotein lipase: from gene to obe-sity. Am J Physiol Endocrinol Metab, 2009, 297(2): E271- E288.
[4] Davies BS, Beigneux AP, Fong LG, Young SG. New wrinkles in lipoprotein lipase biology. Curr Opin Lipidol, 2012, 23(1): 35-42.
[5] 杨宇虹, 穆云祥, 赵郁, 刘新宇, 赵莉莉, 汪军梅, 解用虹. 中国人群脂蛋白脂肪酶基因突变与高脂血症的相关性研究. 遗传学报, 2007, 34(5): 381-391.
[6] 崔璐璐, 王敏, 黄青阳. 脂蛋白酯酶基因Pvu II多态与中国人高脂血症和冠心病的Meta分析. 遗传, 2010, 32(10): 1031-1036.
[7] Goldberg IJ, Soprano DR, Wyatt ML, Vanni TM, Kirchgessner TG, Schotz MC. Localization of lipoprotein lipase mRNA in selected rat tissues. J Lipid Res, 1989, 30(10): 1569-1577.
[8] Bessesen DH, Richards CL, Etienne J, Goers JW, Eckel RH. Spinal cord of the rat contains more lipoprotein lipase than other brain regions. J Lipid Res, 1993, 34(2): 229-238.
[9] Davies BS, Beigneux AP, Barnes RH II, Tu YP, Gin P, Weinstein MM, Nobumori C, Nyrén R, Goldberg I, Olive-crona G, Bensadoun A, Young SG, Fong LG. GPIHBP1 is responsible for the entry of lipoprotein lipase into capil-laries. Cell Metab, 2010, 12(1): 42-52.
[10] Bengtsson G, Olivecrona T. Lipoprotein lipase: mechanism of product inhibition. Eur J Biochem, 1980, 106(2): 557-562.
[11] Ahn J, Lee H, Chung CH, Ha T. High fat diet induced downregulation of microRNA-467b increased lipoprotein lipase in hepatic steatosis. Biochem Biophys Res Commun, 2011, 414(4): 664-669.
[12] Chen T, Li Zb, Tu J, Zhu WG, Ge JH, Zheng XY, Yang L, Pan XP, Yan H, Zhu JH. MicroRNA-29a regulates pro-inflammatory cytokine secretion and scavenger receptor expression by targeting LPL in oxLDL-stimulated den-dritic cells. FEBS Lett, 2011, 585(4): 657-663.
[13] Klinger SC, Glerup S, Raarup MK, Mari MC, Nyegaard M, Koster G, Prabakaran T, Nilsson SK, Kjaergaard MM, Bakke O, Nykjær A, Olivecrona G, Petersen CM, Nielsen MS. SorLA regulates the activity of lipoprotein lipase by intracellular trafficking. J Cell Sci, 2011, 124(7): 1095-1105.
[14] Perdomo G, Kim DH, Zhang T, Qu S, Thomas EA, Toledo FG, Slusher S, Fan Y, Kelley DE, Dong HH. A role of apolipoprotein D in triglyceride metabolism. J Lipid Res, 2010, 51(6): 1298-1311.
[15] Lee JH, Giannikopoulos P, Duncan SA, Wang J, Johansen CT, Brown JD, Plutzky J, Hegele RA, Glimcher LH, Lee AH. The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nat Med, 2011, 17(7): 812-815.
[16] Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG. Glycosylphosphatidylinositol-anchored high-density lipo-protein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons. Cell Metab, 2007, 5(4): 279-291.
[17] Young SG, Davies BS, Fong LG, Gin P, Weinstein MM, Bensadoun A, Beigneux AP. GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chy-lomicrons. Curr Opin Lipidol, 2007, 18(4): 389-396.
[18] Ioka RX, Kang MJ, Kamiyama S, Kim DH, Magoori K, Kamataki A, Ito Y, Takei YA, Sasaki M, Suzuki T, Sasano H, Takahashi S, Sakai J, Fujino T, Yamamoto TT. Ex-pression cloning and characterization of a novel glyco-sylphosphatidylinositol-anchored high density lipopro-tein-binding protein, GPI-HBP1. J Biol Chem, 2003, 278(9): 7344-7349.
[19] Beigneux AP, Weinstein MM, Davies BS, Gin P, Bensa-doun A, Fong LG, Young SG. GPIHBP1 and lipolysis: an update. Curr Opin Lipidol, 2009, 20(3): 211-216.
[20] Beigne

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New insights in regulation factors of lipoprotein lipase

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