特异AT序列结合蛋白2(SATB2)的研究进展

doi:10.3724/SP.J.1005.2011.00947

遗传 ›› 2011, Vol. 33 ›› Issue (9): 947-952.doi: 10.3724/SP.J.1005.2011.00947

特异AT序列结合蛋白2(SATB2)的研究进展

钱琰琰^{1, 2}, 王慧君², 马端^{1, 2}

1. 复旦大学上海医学院分子医学教育部重点实验室, 上海 200032 2. 复旦大学生物医学研究院,复旦大学出生缺陷研究中心, 上海 200032

收稿日期:2010-11-12 修回日期:2010-12-07 出版日期:2011-09-20 发布日期:2011-09-25
通讯作者: 马端 E-mail:duanma@shmu.edu.cn
基金资助:
上海科委基础研究重点项目(编号：10JC1402602)资助

Study progress of special AT-rich sequence binding protein 2

QIAN Yan-Yan^1,2, WANG Hui-Jun², MA Duan^1,2

1. Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China 2. Institutes of Biomedical Science, Resaerch Center for Birth Defects, Fudan University, Shanghai 200032, China

Received:2010-11-12 Revised:2010-12-07 Online:2011-09-20 Published:2011-09-25

摘要/Abstract

摘要： 特异AT序列结合蛋白2(SATB2)是与核基质结合区结合的转录因子, 在转录调控和染色质重组等过程中发挥重要作用。SATB2是成骨细胞分化和骨基质形成过程中的关键调控分子, 其突变可导致先天性颌面部畸形的发生; SATB2是中枢神经系统发育过程中的核心分子, 在胼胝体、脑桥等正常发育中起重要作用; SATB2也参与肿瘤的发生, 在乳腺癌等恶性肿瘤中的表达升高。文章就上述各领域中SATB2的研究进展进行了综述。

关键词: SATB2, 调控因子, 骨骼系统发育, 中枢神经系统发育, 肿瘤

Abstract: SATB2 is a transcription factor, which plays an important role in transcriptional regulation and chromatin recombinant by combining with matrix attachment regions. SATB2 is a key regulatory molecule in the progress of osteoblast differentiation and bone matrix formation. Mutations in this gene are associated with congenital craniofacial malformation. In addition, SATB2 is involved in the development of central nervous system, especially the corpus callosum and the pons. At the same time, SATB2 may participate in the process of tumor formation. In malignant tumors, such as breast cancer, the expression level of SATB2 is higher than normal. The literatures of SATB2 were reviewed in this article.

Key words: SATB2, regulator, bone development, central nervous system development, tumor

钱琰琰，王慧君，马端. 特异AT序列结合蛋白2(SATB2)的研究进展[J]. 遗传, 2011, 33(9): 947-952.

JIAN Yan-Yan, WANG Hui-Jun, MA Duan. Study progress of special AT-rich sequence binding protein 2[J]. HEREDITAS, 2011, 33(9): 947-952.

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特异AT序列结合蛋白2(SATB2)的研究进展

Study progress of special AT-rich sequence binding protein 2

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