Schlafen家族蛋白在肿瘤和病毒感染中的研究进展

doi:10.16288/j.yczz.19-311

[an error occurred while processing this directive]

Hereditas(Beijing) ›› 2020, Vol. 42 ›› Issue (5): 444-451.doi: 10.16288/j.yczz.19-311

• Review • Previous Articles Next Articles

Progress of SLFN family proteins in tumor and virus infection

Shumin Chen, Ling Ma, Shan Cen()

Author Affiliation: Department of Immunology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Union Medical College, Beijing 100050, China

Received:2019-12-05 Revised:2020-04-28 Online:2020-05-20 Published:2020-05-07
Contact: Cen Shan E-mail:shancen@imb.pumc.edu.cn
Supported by:
Supported by CAMS innovation fund for Medical Sciences No(2018-I2M-3-004 SC)

Abstract

Abstract:

Schlafen (SLFN) family genes were initially found in humans and rats to regulate cell growth and T cell differentiation, and exist widely in mice, horses, humans and other species and exhibit high homology. Lines of evidence suggest that SLFN proteins play important roles in inhibiting cell proliferation, promoting meiosis, regulating hematopoietic cells, reducing platelet numbers and the immune response, and also exert antiviral functions against several virus species including HIV-1, influenza virus and others. In addition, SLFN proteins have also been found to be closely related to cancer therapy, and act as a molecular marker to predict tumor development and the sensitivity to chemotherapy drugs. In this review, we discuss the classification, structures, characteristics, location and functions of SLFN family proteins, and focus on progress related to tumor and virus infection, aiming to provide new thoughts on exploration of SLFN protein functions and the underlying mechanisms.

Key words: Schlafen, cell proliferation, tumor, virus

Shumin Chen, Ling Ma, Shan Cen. Progress of SLFN family proteins in tumor and virus infection[J]. Hereditas(Beijing), 2020, 42(5): 444-451.

Figures/Tables 3

Fig. 1

Table 1

Table 2

References 41

[1]	Schwarz DA, Katayama CD, Hedrick SM . Schlafen, a new family of growth regulatory genes that affect thymocyte development . Immunity, 1998,9(5):657-668. doi: 10.1016/S1074-7613(00)80663-9
[2]	Lund S, Christensen KV, Hedtjärn M, Mortensen AL, Hagberg H, Falsig J, Hasseldam H, Schrattenholz A, Pörzgen P, Leist M . The dynamics of the LPS triggered inflammatory response of murine microglia under different culture and in vivo conditions. J Neuroimmunol, 2006,180(1-2):71-87.
[3]	Geserick P, Kaiser F, Klemm U, Kaufmann SH, Zerrahn J . Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif . Int Immunol, 2004. 16(10):1535-1548. doi: 10.1093/intimm/dxh155
[4]	Razzak M . Genetics: Schlafen 11 naturally blocks HIV . Nat Rev Urol, 2012,9(11):605. doi: 10.1038/nrurol.2012.188
[5]	Bustos O, Naik S, Ayers G, Casola C, Perez-Lamigueiro MA, Chippindale PT, Pritham EJ, de la Casa-Esperón E,. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence. Gene, 2009,447(1):1-11. doi: 10.1016/j.gene.2009.07.006
[6]	Neumann B, Zhao L, Murphy K, Gonda TJ . Subcellular localization of the Schlafen protein family. Biochem Biophys Res Commun, 2008,370(1):62-66. doi: 10.1016/j.bbrc.2008.03.032
[7]	Brady G, Boggan L, Bowie A, O'Neill LA. Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1. J Biol Chem, 2005,280(35):30723-30734. doi: 10.1074/jbc.M500435200
[8]	Liu XJ, Lou HQ . Single molecular biology: coming of age in DNA replication. Hereditas(Beijing), 2017,39(9):771-774.
	刘晓晶, 楼慧强 . DNA复制研究步入单分子时代. 遗传, 2017,39(9):771-774.
[9]	Omar I, Guterman-Ram G, Rahat D, Tabach Y, Berger M, Levaot N . Schlafen2 mutation in mice causes an osteopetrotic phenotype due to a decrease in the number of osteoclast progenitors. Sci Rep, 2018,8(1):13005. doi: 10.1038/s41598-018-31428-z
[10]	Cui JJ, Tian GS, Tian D, Zeng Z . An integrated biological model for interferon signaling pathway and its gene polymorphisms. Hereditas(Beijing), 2008,30(6):788-794.
	崔建军, 田庚善, 田地, 曾争 . 干扰素信号传导通路与其基因组多态性网络模型的建立. 遗传, 2008,30(6):788-794.
[11]	Fischietti M, Arslan AD, Sassano A, Saleiro D, Majchrzak-Kita B, Ebine K, Munshi HG, Fish EN, Platanias LC . Slfn2 regulates type i interferon responses by modulating the NF-κB pathway. Mol Cell Biol, 2018,38(16):e00053-18.
[12]	Condamine T, Le Luduec JB, Chiffoleau E, Bériou G, Louvet C, Heslan M, Tilly G, Cuturi MC . Characterization of Schlafen-3 expression in effector and regulatory T cells. J Leukoc Biol, 2010,87(3):451-456. doi: 10.1189/jlb.0609410
[13]	Walsh MF, Hermann R, Sun KL, Basson MD . Schlafen 3 changes during rat intestinal maturation. Am J Surg, 2012,204(5):598-601. doi: 10.1016/j.amjsurg.2012.07.004
[14]	Patel BB, Yu YJ, Du JH, Rishi AK, Sarkar FH, Tarca AL, Wali A, Majumdar APN . Schlafen 3, a novel gene, regulates colonic mucosal growth during aging. Am J Physiol Gastrointest Liver Physiol, 2009,296(4):G955-G962. doi: 10.1152/ajpgi.90726.2008
[15]	Guo F, Luo ZW, Liu ZY, Li YQ, Li HJ, Zhou TH . Studies of effect of prosaposin on cell proliferation, cell apoptosis and its possible molecular mechanism. Hereditas(Beijing), 2009,31(12):1226-1232.
	郭芬, 罗志文, 刘兆宇, 李月琴, 李泓剑, 周天鸿 . prosaposin对细胞增殖和凋亡的调控及其分子机制. 遗传, 2009,31(12):1226-1232.
[16]	Katsoulidis E, Mavrommatis E, Woodard J, Shields MA, Sassano A, Carayol N, Sawicki KT, Munshi HG, Platanias LC . Role of interferon {α} (IFN{α})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells. J Biol Chem, 2010,285(51):40333-40341. doi: 10.1074/jbc.M110.151076
[17]	Li MQ, Kao E, Gao X, Sandig H, Limmer K, Pavon- Eternod M, Jones TE, Landry S, Pan T, Weitzman MD, David M . Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Nature, 2012,491(7422):125-128. doi: 10.1038/nature11433
[18]	Pisareva VP, Muslimov IA, Tcherepanov A, Pisarev AV . Characterization of novel ribosome-associated endoribonuclease SLFN14 from rabbit reticulocytes. Biochemistry, 2015,54(21):3286-3301. doi: 10.1021/acs.biochem.5b00302
[19]	Puck A, Aigner R, Modak M, Cejka P, Blaas D, Stöckl J . Expression and regulation of Schlafen (SLFN) family members in primary human monocytes, monocyte-derived dendritic cells and T cells. Results Immunol, 2015,5:23-32. doi: 10.1016/j.rinim.2015.10.001
[20]	Yang JY, Deng XY, Li YS, Ma XC, Feng JX, Yu B, Chen Y, Luo YL, Wang X, Chen ML, Fang ZX, Zheng FX, Li YP, Zhong Q, Kang TB, Song LB, Xu RH, Zeng MS, Chen W, Zhang H, Xie W, Gao S . Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control. Nat Commun, 2018,9(1):1165. doi: 10.1038/s41467-018-03544-x
[21]	Saes JL, Simons A, de Munnik SA, Nijziel MR, Blijlevens NMA, Jongmans MC, van der Reijden BA, Smit Y, Brons PP, van Heerde WL, Schols SEM. Whole exome sequencing in the diagnostic workup of patients with a bleeding diathesis. Haemophilia, 2019,25(1):127-135. doi: 10.1111/hae.2019.25.issue-1
[22]	Stapley RJ, Pisareva VP, Pisarev AV, Morgan NV . SLFN14 gene mutations associated with bleeding. Platelets, 2019,31(3):407-410. doi: 10.1080/09537104.2019.1648781
[23]	Su W, Wang RC, Lohano MK, Wang L, Zhu P, Luo Y, Guo LJ, Lv Q, Jiang H, Wang JH, Mei L, Weng J, Su L, Dong NG . Identification of two mutations in PCDHGA4 and SLFN14 genes in an atrial septal defect family. Curr Med Sci, 2018,38(6):989-996. doi: 10.1007/s11596-018-1974-2
[24]	Lee NK, Choi HK, Yoo HJ, Shin J, Lee SY . RANKL- induced schlafen2 is a positive regulator of osteoclastogenesis. Cell Signal, 2008,20(12):2302-2308. doi: 10.1016/j.cellsig.2008.08.019
[25]	Horton MR, Powell JD . Quieting T cells with Slfn2. Nat Immunol, 2010,11(4):281-282. doi: 10.1038/ni0410-281
[26]	Companioni Nápoles O, Tsao AC, Sanz-Anquela JM, Sala N, Bonet C, Pardo ML, Ding L, Simo O, Saqui-Salces M, Blanco VP, Gonzalez CA, Merchant JL . SCHLAFEN 5 expression correlates with intestinal metaplasia that progresses to gastric cancer. J Gastroenterol, 2017,52(1):39-49. doi: 10.1007/s00535-016-1202-4
[27]	Kovalenko PL, Basson MD . Schlafen 12 expression modulates prostate cancer cell differentiation. J Surg Res, 2014,190(1):177-184. doi: 10.1016/j.jss.2014.03.069
[28]	Wu XY, Schnitzler GR, Gao GF, Diamond B, Baker AR, Kaplan B, Williamson K, Westlake L, Lorrey S, Lewis TA, Garvie CW, Lange M, Hayat S, Seidel H, Doench J, Cherniack AD, Kopitz C, Meyerson M, Greulich H . Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12. J Biol Chem, 2020,295(11):3431-3446. doi: 10.1074/jbc.RA119.011191
[29]	Katsoulidis E, Carayol N, Woodard J, Konieczna I, Majchrzak-Kita B, Jordan A, Sassano A, Eklund EA, Fish EN, Platanias LC . Role of Schlafen 2 (SLFN2) in the generation of interferon α-induced growth inhibitory responses. J Biol Chem, 2009,284(37):25051-25064. doi: 10.1074/jbc.M109.030445
[30]	Oh PS, Patel VB, Sanders MA, Kanwar SS, Yu Y, Nautiyal J, Patel BB, Majumdar AP . Schlafen-3 decreases cancer stem cell marker expression and autocrine/juxtacrine signaling in FOLFOX-resistant colon cancer cells. Am J Physiol Gastrointest Liver Physiol, 2011,301(2):G347-G355. doi: 10.1152/ajpgi.00403.2010
[31]	Barretina J, Caponigro G., Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehar J, Kryukov GV, Sonkin D, Reddy A, Liu M, Murray L, Berger MF, Monahan JE, Morais P, Meltzer J, Korejwa A, Jané- Valbuena J, Mapa FA, Thibault J, Bric-Furlong E, Raman P, Shipway A, Engels IH, Cheng J, Yu GK, Yu J, Aspesi P, de Silva M, Jagtap K, Jones MD, Wang L, Hatton C, Palescandolo E, Gupta S, Mahan S, Sougnez C, Onofrio RC, Liefeld T, MacConaill L, Winckler W, Reich M, Li N, Mesirov JP, Gabriel SB, Getz G, Ardlie K, Chan V, Myer VE, Weber BL, Porter J, Warmuth M, Finan P, Harris JL, Meyerson M, Golub TR, Morrissey MP, Sellers WR, Schlegel R, Garraway LA. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature, 2012,483(7391):603-607. doi: 10.1038/nature11003
[32]	Zoppoli G, Regairaz M, Leo E, Reinhold WC, Varma S, Ballestrero A, Doroshow JH, Pommier Y . Putative DNA/ RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents. Proc Natl Acad Sci USA, 2012,109(37):15030-15035.
[33]	Kaur S, Schwartz AL, Jordan DG, Soto-Pantoja DR, Kuo B, Elkahloun AG, Mathews GL, Thomas CJ, Ferrer M, Thomas A, Tang SW, Rajapakse VN, Pommier Y, Roberts DD . Identification of Schlafen-11 as a target of CD47 signaling that regulates sensitivity to ionizing radiation and topoisomerase inhibitors. Front Oncol, 2019,9:994. doi: 10.3389/fonc.2019.00994
[34]	Marzi L, Szabova L, Gordon M, Weaver Ohler Z, Sharan SK, Beshiri ML, Etemadi M, Murai J, Kelly K, Pommier Y . The indenoisoquinoline TOP1 inhibitors selectively target homologous recombination-deficient and Schlafen 11- positive cancer cells and synergize with olaparib. Clin Cancer Res, 2019,25(20):6206-6216.
[35]	Malone D, Lardelli RM, Li M, David M . Dephosphorylation activates the interferon-stimulated Schlafen family member 11 in the DNA damage response. J Biol Chem, 2019,294(40):14674-14685.
[36]	Wang J, Zhou JG, Huang CF . Tructure of the PSA promoter and the mechanisms of its expression regulation. Hereditas(Beijing), 2004,26(5):739-744.
	王健, 周建光, 黄翠芬 . PSA启动子结构和表达调控研究进展. 遗传, 2004,26(5):739-744.
[37]	Li DR, Chen J, Ai YW, Gu XQ, Li L, Che D, Jiang ZD, Li L, Chen S, Huang HW, Wang JW, Cai T, Cao Y, Qi XB, Wang XD. Estrogen-related hormones induce apoptosis by stabilizing schlafen-12 protein turnover. Mol Cell, 2019, 75(6): 1103-1116. e9. doi: 10.1016/j.molcel.2019.06.040
[38]	Lin YZ, Sun LK, Zhu DT, Hu Z, Wang XF, Du C, Wang YH, Wang XJ, Zhou JH . Equine schlafen 11 restricts the production of equine infectious anemia virus via a codon usage-dependent mechanism. Virology, 2016,495:112-121.
[39]	Valdez F, Salvador J, Palermo PM, Mohl JE, Hanley KA, Watts D, Llano M . Schlafen 11 restricts flavivirus replication. J Virol, 2019. 93(15):e00140-19.
[40]	Kane M, Zang TM, Rihn SJ, Zhang F, Kueck T, Alim M, Schoggins J, Rice CM, Wilson SJ, Bieniasz PD . Identification of interferon-stimulated genes with antiretroviral activity. Cell Host Microbe, 2016,20(3):392-405.
[41]	Seong RK, Seo SW, Kim JA, Fletcher SJ, Morgan NV, Kumar M, Choi YK, Shin OS . Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication. Immunobiology, 2017,222(11):979-988.

Metrics

Comments

www.chinagene.cn
备案号：京ICP备09063187号

SLFN	对肿瘤细胞的影响	参考文献
m-SLFN2	抑制肿瘤细胞转移;激活c-Jun、NFATc1蛋白表达,诱导破骨细胞癌变;抑制黑色素瘤细胞增殖	[24,25,29]
m-SLFN3	抑制CSC增殖分化,提高结肠癌细胞对抗肿瘤药物敏感性	[30]
h-SLFN5	抑制黑色素瘤细胞锚定依赖生长;胃癌细胞高表达,可作为胃癌发展过程组织学诊断标志	[13,26]
h-SLFN11	靶向剪切胞内ATR/ATM蛋白翻译所需tRNA,提高肿瘤细胞对电离辐射、拓扑异构酶抑制剂以及DDA敏感性,促进肿瘤细胞周期停滞和凋亡	[31~35]
h-SLFN12	SLFN12-PDE3A复合物下调胞内Bcl-2和Mcl-1蛋白水平,靶向诱导PDE3A高表达肿瘤细胞凋亡	[27,28,36,37]

SLFN	对病毒的影响	参考文献
h-SLFN11	识别HIV-1密码子偏好性,抑制HIV-1病毒复制; 下调宿主细胞tRNA丰度,选择性抑制单正链RNA病毒(WNV、DENV和ZIKV等)复制	[17,38,39]
h-SLFN12	抑制HIV-1、EIAV、HERV-K、MLV及PFV等逆转录病毒复制	[40]
h-SLFN13	选择性地剪切病毒RNA,抑制HIV-1;抑制ZIKV病毒复制	[20]
h-SLFN14	增强IFN抗病毒活性,抑制流感病毒复制;抑制HIV病毒复制	[41]

Progress of SLFN family proteins in tumor and virus infection

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 3

References 41

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Qingyu Sun, Yang Zhou, Lijuan Du, Mengke Zhang, Jiale Wang, Yuanyuan Ren, Fang Liu. Analysis between macrophage-related genes with prognosis and tumor microenvironment in non-small cell lung cancer [J]. Hereditas(Beijing), 2023, 45(8): 684-699.
[2]	Chenghao Yan, Weiyu Bai, Zhimeng Zhang, Junling Shen, Youjun Wang, Jianwei Sun. The roles and mechanism of STIM1 in tumorigenesis and metastasis [J]. Hereditas(Beijing), 2023, 45(5): 395-408.
[3]	Chunhui Ma, Haixu Hu, Lijuan Zhang, Yi Liu, Tianyi Liu. Establishment and verification of a digital PCR assay for the detection of CK19 expression in quantitative analysis of circulating tumor cell [J]. Hereditas(Beijing), 2023, 45(3): 250-260.
[4]	Dong Chang, Xiangxiang Liu, Rui Liu, Jianwei Sun. The role and regulatory mechanism of FSCN1 in breast tumorigenesis and progression [J]. Hereditas(Beijing), 2023, 45(2): 115-127.
[5]	Qinggang Hao, Fenggui Sun, Chenghao Yan, Jianwei Sun. Progress on the role and mechanism of MT1-MMP in tumor metastasis [J]. Hereditas(Beijing), 2022, 44(9): 745-755.
[6]	Yan Zhao, Chenxin Wang, Tianming Yang, Chunshuang Li, Lihong Zhang, Dongni Du, Ruoxi Wang, Jing Wang, Min Wei, Xueqing Ba. Linking oxidative DNA lesion 8-OxoG to tumor development and progression [J]. Hereditas(Beijing), 2022, 44(6): 466-477.
[7]	Youhong Chen, Wenhao Yang, Chao Ni. Using esophagus organoid to explore the role of c-Myc in esophageal cancer initiation [J]. Hereditas(Beijing), 2021, 43(6): 601-614.
[8]	Yanni Kou, Shan Cen, Xiaoyu Li. Research and application on LINE-1 in diagnosis and treatment of tumorigenesis [J]. Hereditas(Beijing), 2021, 43(6): 571-579.
[9]	Zhuo Wang, Xiaohan Shen, Qihui Shi. Advances in single-cell whole genome sequencing technology and its application in biomedicine [J]. Hereditas(Beijing), 2021, 43(2): 108-117.
[10]	Enquan Zhang, Weicong Cai, Guiling Li, Jian Li, Jingwen Liu. Analysis of microRNA expression profile in Emiliania huxleyi in response to virus infection [J]. Hereditas(Beijing), 2021, 43(11): 1088-1100.
[11]	Chunmei Xie, Haiping Wu, Xueping Ma, Guohua Zhou. New molecular diagnostic technologies for clinical detection of SARS-CoV-2 [J]. Hereditas(Beijing), 2020, 42(9): 870-881.
[12]	Linan Zhao, Na Wang, Guoliang Yang, Xianbin Su, Zeguang Han. A method for reliable detection of genomic point mutations based on single-cell target-sequencing [J]. Hereditas(Beijing), 2020, 42(7): 703-712.
[13]	Liang Qu, Su Li, Huaji Qiu. Applications of single-cell RNA sequencing in virology [J]. Hereditas(Beijing), 2020, 42(3): 269-277.
[14]	Qiang Zhang, Mingliang Gu. Single-cell sequencing and its application in breast cancer [J]. Hereditas(Beijing), 2020, 42(3): 250-268.
[15]	Wenming Zhao, Shuhui Song, Meili Chen, Dong Zou, Lina Ma, Yingke Ma, Rujiao Li, Lili Hao, Cuiping Li, Dongmei Tian, Bixia Tang, Yanqing Wang, Junwei Zhu, Huanxin Chen, Zhang Zhang, Yongbiao Xue, Yiming Bao. The 2019 novel coronavirus resource [J]. Hereditas(Beijing), 2020, 42(2): 212-221.