2型糖尿病环境因素与DNA甲基化的研究进展

doi:10.3724/SP.J.1005.2013.01143

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HEREDITAS ›› 2013, Vol. 35 ›› Issue (10): 1143-1152.doi: 10.3724/SP.J.1005.2013.01143

The effect of environmental factors and DNA methylation on type 2 diabetes mellitus

TANG Lin-Lin¹, LIU Qiong^1,2, BU Shi-Zhong^1,2, XU Lei-Ting^1,2, WANG Qin-Wen^1,2, MAI Yi-Feng³, DUAN Shi-Wei^1,2

1. Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China;
2. Diabetes Center, Ningbo University, Ningbo 315211, China;
3. The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo 315000, China

Received:2013-04-25 Revised:2013-07-04 Online:2013-10-20 Published:2013-10-25

Abstract

Abstract:

Type 2 diabetes mellitus (T2DM) is a glucose metabolic disorder driven by both genetic and environmental factors. Recent DNA methylation studies have established that T2DM may be contributed by environmental factors through the regulation of DNA methylation. Human and animal model studies have made much progress on the interaction between DNA methylation of T2DM genes and environmental factors in multiple tissues. Current studies on DNA methylation of T2DM genes mainly focus on glucose and energy metabolism, inflammation, and so on. This review comprehensively introduces the DNA methylation studies for the genes involved in T2DM and its related environmental factors.

Key words: type 2 diabetes mellitus, epigenetics, DNA methylation, environmental factors

TANG Lin-Lin LIU Qiong BU Shi-Zhong XU Lei-Ting WANG Qin-Wen MAI Yi-Feng DUAN Shi-Wei. The effect of environmental factors and DNA methylation on type 2 diabetes mellitus[J]. HEREDITAS, 2013, 35(10): 1143-1152.

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The effect of environmental factors and DNA methylation on type 2 diabetes mellitus

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