基因组学：揭秘人类特有遗传变异对大脑皮层进化与发育的影响

doi:10.16288/j.yczz.16-102

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Hereditas(Beijing) ›› 2016, Vol. 38 ›› Issue (11): 957-970.doi: 10.16288/j.yczz.16-102

Genomics: disclose the influence of human specific genetic variation on the evolution and development of cerebral cortex

Maomao Pu, Jun Yao, Xin Cao

Department of Biology Technology, Nanjing Medical University, Nanjing 211166, China

Received:2016-03-24 Revised:2016-07-28 Online:2016-11-20 Published:2016-08-04

Abstract

Abstract: Cerebral cortex, whose complexity of structure and function has derived from human specific genetic variation, is the most advanced nerve center of human, controlling the cognitive ability which distinguishes human from any other creatures. Using genomics technology, molecular mechanisms of cerebral cortex development and evolution have been disclosed. In this review, we summarize how genomics technologies are used in exploring the influence of human specific genetic variation on cerebral cortex development and evolution, including the genomics methods to study the gene expression differences among the cerebral cortex of human beings, chimpanzee and other mammals; as well as the role of the significant non-coding regulatory sequences—human accelerated regions (HARs) in the process of brain development. We also discuss the future research trends on the human specific genetic variation in the field of neurobiology.

Key words: genomics, development, cerebral cortex, molecular evolution

Maomao Pu, Jun Yao, Xin Cao. Genomics: disclose the influence of human specific genetic variation on the evolution and development of cerebral cortex[J]. Hereditas(Beijing), 2016, 38(11): 957-970.

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Genomics: disclose the influence of human specific genetic variation on the evolution and development of cerebral cortex

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