脊椎动物染色体在序列和空间构象的演化

doi:10.16288/j.yczz.24-212

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Hereditas(Beijing) ›› 2025, Vol. 47 ›› Issue (2): 183-199.doi: 10.16288/j.yczz.24-212

• Review • Previous Articles Next Articles

The evolution of sequences and spatial conformation in vertebrate chromosomes

Jing Liu(), Qi Zhou()

MOE Laboratory of Biosystems Homeostasis and Protection and Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China

Received:2024-07-18 Revised:2024-09-02 Online:2025-02-20 Published:2024-10-11
Contact: Qi Zhou E-mail:liujing1993@zju.edu.cn;zhouqi1982@zju.edu.cn
Supported by:
National Key Research and Development Program of China(2023YFA1800500);National Natural Science Foundation of China(32170415)

Abstract

Abstract:

Chromosomes, as the fundamental unit of genetic material located within the cell nucleus, have undergone extensive and complex changes throughout the evolutionary history of eukaryotes. Many of these patterns and mechanisms of change share commonalities across various diseases, including cancer. For a long time, biologists were limited to research methods with relatively low resolution, such as fluorescence in situ hybridization (FISH). However, the rapid advancement of high-throughput sequencing technologies is revolutionizing our understanding of chromosomal variations across different species, among individuals of the same species, and even at the cellular level within a single individual. In this review, we focus on the chromosomal evolution in vertebrates, and provide an overview of the role of chromosom rearrangements in speciation, the molecular mechanisms of chromosomal rearrangements, the evolutionary patterns from ancestral chromosomes to extant chromosomes, and the significance of sex chromosomes as a general paradigm for studying chromosomal evolution. Finally, we discuss the new opportunities and challenges that synthetic biology brings to the field of chromosomal evolution research, with the aim of offering new insights and references for understanding and studying vertebrate chromosomal evolution.

Key words: chromosome, vertebrate, chromosomal rearrangement, sex chromosome

Jing Liu, Qi Zhou. The evolution of sequences and spatial conformation in vertebrate chromosomes[J]. Hereditas(Beijing), 2025, 47(2): 183-199.

Figures/Tables 4

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The evolution of sequences and spatial conformation in vertebrate chromosomes

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