基因概念的演绎

doi:10.3724/SP.J.1005.2010.00448

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (5): 448-454.doi: 10.3724/SP.J.1005.2010.00448

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The development of gene concepts

XIE Zhao-Hui

Department of Biology, Dezhou University, Dezhou 253023, China

Received:2009-09-15 Revised:2009-10-10 Online:2010-05-20 Published:2010-05-05
Contact: XIE Zhao-Hui E-mail:xiezhh0523@163.com

Abstract

Abstract:

One hundred years has passed since the term of “gene” was coined in 1909, the gene defination has been revised many times in the past 100 years. Gene has changed from an abstract symbol to a specific segment, which can produce protein or functional RNA, and finally became one of the most important biological words. With the accomplishment of the genome project, particularly the project of Encyclopedia of DNA Elements (ENCODE), our knowledge about the the complexity and diversity of genomic organization and dynamics of genomes posed important challenges to the classical molecular gene concept. As is becoming more evident that the relations between information stored at DNA level and functional products are very intricate, some people consider that it was time to make a redefinition of gene. In this review, we briefly outline gene defination of this history and the development of gene concept these days.

Key words: gene, gene defination, debate

XIE Zhao-Hui. The development of gene concepts[J]. HEREDITAS, 2010, 32(5): 448-454.

References

[1] Gelbart W. Databases in genomic research. Science, 1998, 282(5389): 659–661.

[2] Keller EF. The Century of the Gene. Harvard University Press, Cambridge, 2000, 192.

[3] Gahtan V, Olson ET, Sumpio BE. Molecular biology: a brief overview. J Vasc Surg, 2002, 35(3): 563–568.

[4] Falk R. "What is a gene?" Studies History Philosophy Sci, 1986, 17(2): 133–173

[5] Venville G, Donovan J. Searching for clarity to teach the complexity of the gene concept. Teaching Sci, 2005, 51(3): 20–24.

[6] Griffiths PE, Stotz K. Genes in the postgenomic era. Theor Med Bioeth, 2006, 27(6): 499–521.

[7] Gerstein MB, Bruce C, Rozowsky JS, Zheng D, Du J, Korbel JO, Emanuelsson O, Zhang ZD, Weissman S, Snyder M. What is a gene, post-ENCODE? History and updated definition. Genome Res, 2007, 17(6): 669–681. [8] 高翼之. “基因”一词的由来. 遗传, 2000, 22(2): 107–108.

[9] Liu Y. Reversion: going back to Darwin's works. Trends Plant Sci, 2005, 10(10): 459–460.

[10] Boveri T. Über mehrpolige Mitosen als Mittel zur Analyse des Zellkerns. Verh Phys. Med Ges Würzburg, 1902, 35: 67–90.

[11] Sutton WS. The chromosomes in heredity. Bio Bull, 1903, 4: 231–251.

[12] Morgan TH. Sex-limited inheritance in Drosophila. Sci-ence, 1910, 32(812): 120–122.

[13] Beadle GW, Tatum EL. Genetic Control of Biochemical Reactions in Neurospora. Proc Natl Acad Sci USA, 1941, 27(11): 499–506.

[14] Benzer S. Fine structre of a genetic region in bacterio-phage. Proc Natl Acad Sci USA, 1955, 41(6): 344–354.

[15] El-Hani CN. Between the cross and the sword: the crisis of the gene concept. Genet Mol Biol, 2007, 30(2): 297–307.

[16] Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG. The sequence of the human genome, Science, 2001, 291(5507): 1304–1351.

[17] Akiva P, Toporik A, Edelheit S, Peretz Y, Diber A, Shemesh R, Novik A, Sorek R. Transcription-mediated gene fusion in the human genome. Genome Res, 2006, 16(1): 30–36.

[18] Sanger F, Coulson AR, Friedmann T, Air GM, Barrell BG, Brown NL, Fiddes JC, Hutchison CA 3rd, Slocombe PM, Smith M. The nucleotide sequence of bacteriophage phiX174. J Mol Biol, 1978, 125(2): 225–246.

[19] Amaral PP, Dinger ME, Mercer TR, Mattick JS. The eu-karyotic genome as an RNA machine. Science, 2008, 319(5871):1787–1789.

[20] Lapidot M, Pilpel Y. Genome-wide natural antisense tran-scription: coupling its regulation to its different regulatory mechanisms. EMBO Rep, 2006, 7(12): 1216–1222.

[21] Luedi PP, Dietrich FS, Weidman JR, Bosko JM, Jirtle RL, Hartemink AJ. Computational and experimental identifi-cation of novel human imprinted genes. Genome Res, 2007, 17(12): 1723–1730.

[22] 张意军, 屈良鹄. 非编码RNA与哺乳动物基因组印记的起源. 中国科学 (C辑), 2009, 39(1): 3–12.

[23] Pace JK 2nd, Gilbert C, Clark MS, Feschotte C. Repeated horizontal transfer of a DNA transposon in mammals and other tetrapods. Proc Natl Acad Sci USA, 2008, 105(44): 17023–17028.

[24] Jacq C, Miller JR, Brownlee GG. A pseudogene structure in 5S DNA of Xenopus laevis. Cell, 1977, 12(1): 109–120.

[25] Sasidharan R, Gerstein M. Genomics: protein fossils live on as RNA. Nature, 2008, 453(7196): 729–731. [26] Bekpen C, Marques-Bonet T, Alkan C, Antonacci F, Leogrande MB, Ventura M, Kidd JM, Siswara P, Howard JC, Eichler EE. Death and resurrection of the human IRGM gene. PLoS Genet, 2009, 5(3): e1000403.

[27] Burian RM. Molecular epigenesis, molecular pleiotropy, and molecular gene definitions. Hist Philos Life Sci, 2004, 26(1): 59–80.

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