遗传 ›› 2015, Vol. 37 ›› Issue (9): 873-884.doi: 10.16288/j.yczz.15-146
庞晓楠1, 3, 弘笑3, 魏璇2, 陈喜文4, 刘佳2, 陈德富1, 3
收稿日期:2015-04-09
修回日期:2015-07-29
出版日期:2015-09-20
发布日期:2015-09-20
通讯作者:
刘佳,副研究员,研究方向：生物化学。E-mail: liujia@shanghaitech.edu.cn 陈德富,教授,博士生导师,研究方向：分子遗传学。E-mail: chendefu@nankai.edu.cn
作者简介:庞晓楠,博士研究生,专业方向：分子遗传学。Tel: 022-23508270;E-mail: fightingnk@163.com
基金资助:Xiaonan Pang1, 3, Xiao Hong3, Xuan Wei2, Xiwen Chen4, Jia Liu2, Defu Chen1, 3
Received:2015-04-09
Revised:2015-07-29
Online:2015-09-20
Published:2015-09-20
摘要： 乳铁蛋白(Lactoferrin, Lf)是分子量大小约为80 kDa的铁离子结合糖蛋白,是转铁蛋白(Transferrin, Tf)家族的成员之一。其理化性质独特,具有抑菌、抗病毒、抗癌、免疫调节、调节铁离子的吸收等诸多生物学功能。获得高产且有生物活性的重组乳铁蛋白,并用于临床治疗,一直是研究热点。随着基因工程技术的发展,已获得多个可表达重组乳铁蛋白的表达系统。本文对乳铁蛋白的理化性质、生物学活性、临床研究以及目前的重组表达系统进行综述,以期为乳铁蛋白的临床应用提供参考。
庞晓楠, 弘笑, 魏璇, 陈喜文, 刘佳, 陈德富. 乳铁蛋白的理化性质及其重组表达系统的研究进展[J]. 遗传, 2015, 37(9): 873-884.
Xiaonan Pang, Xiao Hong, Xuan Wei, Xiwen Chen, Jia Liu, Defu Chen. Research progress in physicochemical characteristics of lactoferrin and its recombinant expression systems[J]. HEREDITAS(Beijing), 2015, 37(9): 873-884.
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