时间生物学—2017年诺贝尔生理或医学奖解读

doi:10.16288/j.yczz.17-397

遗传 ›› 2018, Vol. 40 ›› Issue (1): 1-11.doi: 10.16288/j.yczz.17-397

• 前沿聚焦 • 下一篇

时间生物学—2017年诺贝尔生理或医学奖解读

袁力,李艺柔,徐小冬

河北师范大学生命科学学院,石家庄 050024

收稿日期:2017-12-04 修回日期:2017-12-22 出版日期:2018-01-20 发布日期:2017-12-27
基金资助:
国家自然科学基金(编号：31570285),教育部新世纪优秀人才支持计划(编号：NCET-13-0771),河北省教育厅研究生创新资助项目(编号：CXZZBS2017093)和河北师范大学大学生创新创业计划(编号：201710094011)资助

Chronobiology—2017 Nobel Prize in Physiology or Medicine

Yuan Li,Li Yirou,Xu Xiaodong

Hebei Normal University, College of Life Sciences, Shijiazhuang 050024, China

Received:2017-12-04 Revised:2017-12-22 Online:2018-01-20 Published:2017-12-27
Supported by:
[Supported by the National Natural Science Foundation of China (No. 31570285), Program for New Century Excellent Talents in University (No. NCET-13-0771), Graduate Student Innovation Fund of Hebei Province (No. CXZZBS2017093), and Hebei Normal University Undergraduate Student Training Grant (No. 201710094011)]

摘要/Abstract

摘要：

时间生物学主要研究生物节律的产生及生物钟的运行机制,2017年诺贝尔生理或医学奖的颁布再次引发人们对该领域诸多科学问题的高度关注。生物钟与日月运行引起的环境信号周期性保持同步,有利于生物节律的相位和组织稳态的精确维持。本文介绍了生物节律现象的早期研究及随后生物钟理论体系建立的发展简史,并结合2017年诺贝尔生理或医学奖的解读阐述了果蝇生物钟基因的发现与分子调控机理,进而简单归纳当前时间生物学领域的前沿科学问题,阐明生物钟研究的意义。

关键词: 时间生物学, 生物钟, 近日节律, 组织稳态, 环境适应性

Abstract:

Chronobiology is a field of biology that examines the generation of biological rhythms in various creatures and in many parts of body, and their adaptive fitness to solar- and lunar-related periodic phenomena. The synchronization of internal circadian clocks with external timing signals confers accurate phase response and tissue homeostasis. Herein we state a series of studies on circadian rhythms and introduce the brief history of chronobiology. We also present a detailed timeline of the discoveries on molecular mechanisms controlling circadian rhythm in Drosophila, which was awarded the 2017 Nobel Prize in Physiology or Medicine. The latest findings and new perspectives are further summarized to indicate the significance of circadian research.

Key words: chronobiology, biological clock, circadian rhythms, tissue homeostasis, fitness

袁力, 李艺柔, 徐小冬. 时间生物学—2017年诺贝尔生理或医学奖解读[J]. 遗传, 2018, 40(1): 1-11.

Yuan Li, Li Yirou, Xu Xiaodong. Chronobiology—2017 Nobel Prize in Physiology or Medicine[J]. Hereditas(Beijing), 2018, 40(1): 1-11.

参考文献

[1]	de Mairan J. Observation botanique. Hist Acad Roy Sci, 1729, 1729: 35-36.
[2]	Duhamel du Monceau H. La physique des arbres: ou il est traite de I'anatomie des plantes et de I'economie vegetale. Paris: H.L.Guerin & L.F.Delatour, 1758.
[3]	de Candolle AP. Physiologie Végétale, Ou Exposition Des Forces et Des Fonctions Vitales des Végétaux. Paris: Béchet Jeune, 1832.
[4]	Richter CP. A behavioristic study of the activity of the rat. Comp Psychol Monogr, 1922, 1(2): 56.
[5]	Richter CP. Inherent twenty-four hour and lunar clocks of a primate—the squirrel monkey. Commun Behav Biol, 1968, 1: 305-332.
[6]	Bunning E. The Physiological Clock: Endogenous Diurnal Rhythms and Biological Chronometry. Berlin Heidelberg: Springer-Verlag, 1964.
[7]	Pohl R. Tagesrhythmus im phototaktischen Verhalten der Euglena gracilis. Z. Naturforsch. B Chem. Sci, 1948, 3(9- 10): 367-374.
[8]	Pittendrigh CS. On temperature independence in the clock system controlling emergence time inDrosophila. Proc Natl Acad Sci USA, 1954, 40(10): 1018-1029.
[9]	Pittendrigh CS. Circadian systems: entrainment. In: Aschoff J, ed. Handbook of Behavioral Neurobiology. New York: University of California Press, 1981, 4: 95-124.
[10]	Lerner AB, Case JD, Takahashi Y, Lee TH, Mori W. Isolation of melatonin, the pineal gland factor that lightens melanocyteS1. J Am Chem Soc, 1958, 80(10): 2587.
[11]	Redman J, Armstrong S, Ng KT. Free-running activity rhythms in the rat: entrainment by melatonin. Science, 1983, 219(4588): 1089-1091.
[12]	Von Aschoff J, Wever R. Spontanperiodik des menschen bei ausschlu? aller zeitgeber. Naturwissenschaften, 1962, 49(15): 337-342.
[13]	Aschoff J. Circadian rhythms in man. Science, 1965, 148(3676): 1427-1432.
[14]	Carpenter GA, Grossberg S. A neural theory of circadian rhythms: aschoff's rule in diurnal and nocturnal mammals. Am J Physiol, 1984, 247(6 Pt 2): R1067-R1082.
[15]	Konopka RJ, Benzer S. Clock mutants ofDrosophila melanogaster. Proc Natl Acad Sci USA, 1971, 68(9): 2112-2116.
[16]	Bruce VG. Mutants of the biological clock inChlamydomonas reinhardi. Genetics, 1972, 70(4): 537-548.
[17]	Feldman JF, Hoyle MN. Isolation of circadian clock mutants ofNeurospora crassa. Genetics, 1973, 75(4): 605-613.
[18]	Bargiello TA, Young MW. Molecular genetics of a biological clock inDrosophila. Proc Natl Acad Sci USA, 1984, 81(7): 2142-2146.
[19]	Bargiello TA, Jackson FR, Young MW. Restoration of circadian behavioural rhythms by gene transfer inDrosophila. Nature, 1984, 312(5996): 752-754.
[20]	Reddy P, Zehring WA, Wheeler DA, Pirrotta V, Hadfield C, Hall JC, Rosbash M. Molecular analysis of theperiod locus in Drosophila melanogaster and identification of a transcript involved in biological rhythms. Cell, 1984, 38(3): 701-710.
[21]	Zehring WA, Wheeler DA, Reddy P, Konopka RJ, Kyriacou CP, Rosbash M, Hall JC. P-element transformation withperiod locus DNA restores rhythmicity to mutant, arrhythmic drosophila melanogaster. Cell, 1984, 39(2): 369-376.
[22]	Ralph MR, Menaker M. A mutation of the circadian system in golden hamsters. Science, 1988, 241(4870): 1225-1227.
[23]	Vitaterna MH, King DP, Chang AM, Kornhauser JM, Lowrey PL, McDonald JD, Dove WF, Pinto LH, Turek FW, Takahashi JS. Mutagenesis and mapping of a mouse gene, clock, essential for circadian behavior. Science (New York, NY), 1994, 264(5159): 719-725.
[24]	Loros JJ, Denome SA, Dunlap JC. Molecular cloning of genes under control of the circadian clock inNeurospora. Science, 1989, 243(4889): 385-388.
[25]	King DP, Zhao YL, Sangoram AM, Wilsbacher LD, Tanaka M, Antoch MP, Steeves TDL, Vitaterna MH, Kornhauser JM, Lowrey PL, Turek FW, Takahashi JS. Positional cloning of the mouse circadianclock gene. Cell, 1997, 89(4): 641-653.
[26]	Shearman LP, Zylka MJ, Weaver DR, Kolakowski Jr LF, Reppert SM. Twoperiod homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron, 1997, 19(6): 1261-1269.
[27]	Tei H, Okamura H, Shigeyoshi Y, Fukuhara C, Ozawa R, Hirose M, Sakaki Y. Circadian oscillation of a mammalian homologue of theDrosophila period gene. Nature, 1997, 389(6650): 512-516.
[28]	Wang ZY, Kenigsbuch D, Sun L, Harel E, Ong MS, Tobin EM. A Myb-related transcription factor is involved in the phytochrome regulation of an ArabidopsisLhcb gene. Plant Cell, 1997, 9(4): 491-507.
[29]	Siwicki KK, Eastman C, Petersen G, Rosbash M, Hall JC. Antibodies to theperiod gene product of Drosophila reveal diverse tissue distribution and rhythmic changes in the visual system. Neuron, 1988, 1(2): 141-150.
[30]	Hardin PE, Hall JC, Rosbash M. Feedback of theDrosophila period gene product on circadian cycling of its messenger RNA levels. Nature, 1990, 343(6258): 536-540.
[31]	Liu X, Zwiebel LJ, Hinton D, Benzer S, Hall JC, Rosbash M. The period gene encodes a predominantly nuclear protein in adultDrosophila. J Neurosci, 1992, 12(7): 2735-2744.
[32]	Sehgal A, Price JL, Man B, Young MW. Loss of circadian behavioral rhythms and per RNA oscillations in theDrosophila mutant timeless. Science, 1994, 263(5153): 1603-1605.
[33]	Vosshall LB, Price JL, Sehgal A, Saez L, Young MW. Block in nuclear localization of period protein by a second clock mutation, timeless. Science, 1994, 263(5153): 1606-1610.
[34]	Hunter-Ensor M, Ousley A, Sehgal A. Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light. Cell, 1996, 84(5): 677-685.
[35]	Price JL, Blau J, Rothenfluh A, Abodeely M, Kloss B, Young MW. Double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell, 1998, 94(1): 83-95.
[36]	Ishiura M, Kutsuna S, Aoki S, Iwasaki H, Andersson CR, Tanabe A, Golden SS, Johnson CH, Kondo T. Expression of a gene clusterkaiABC as a circadian feedback process in cyanobacteria. Science, 1998, 281(5382): 1519-1523.
[37]	Nakajima M, Imai K, Ito H, Nishiwaki T, Murayama Y, Iwasaki H, Oyama T, Kondo T. Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro. Science, 2005, 308(5720): 414-415.
[38]	Aronson BD, Johnson KA, Loros JJ, Dunlap JC. Negative feedback defining a circadian clock: autoregulation of the clock gene frequency. Science, 1994, 263(5153): 1578-1584.
[39]	Cohen SE, Golden SS. Circadian rhythms in cyanobacteria. Microbiol Mol Biol Rev, 2015, 79(4): 373-385.
[40]	Partch CL, Green CB, Takahashi JS. Molecular architecture of the mammalian circadian clock. Trends Cell Biol, 2014, 24(2): 90-99.
[41]	Xu XD , Xie QG. The circadian clock in plants. Chin J Nat, 2013, 35( 2): 118- 126.
[41]	徐小冬, 谢启光. 植物生物钟研究的历史回顾与最新进展. 自然杂志, 2013, 35( 2): 118- 126.
[42]	Brown SA, Kowalska E, Dallmann R.( Re) inventing the circadian feedback loop. Dev Cell, 2012, 22(3): 477-487.
[43]	An Y , Xu Y. The mechanism of mammalian circadian rhythms. Chin Bull Life Sci, 2015, 27( 11): 1372- 1379.
[43]	安扬, 徐璎. 哺乳动物昼夜节律机制研究进展. 生命科学, 2015, 27( 11): 1372- 1379.
[44]	Zhang LY , Ye XX. The regulatory mechanism of Drosophila circadian rhythm. Chin Bull Life Sci, 2015, 27( 11): 1345- 1354.
[44]	张珞颖, 叶晓雪. 果蝇昼夜节律的调控机制. 生命科学, 2015, 27( 11): 1345- 1354.
[45]	Wang MY , Huang GD , Wang H. Advances in the zebrafish circadian clock mechanisms. Hereditas (Beijing), 2012, 34( 9): 1133- 1143.
[45]	王明勇, 黄国栋, 王晗. 斑马鱼生物钟研究进展. 遗传, 2012, 34( 9): 1133- 1143.
[46]	Science. So much more to know. Science, 2005, 309(5731): 78-102.
[47]	Kojima S, Shingle DL, Green CB. Post-transcriptional control of circadian rhythms. J Cell Sci, 2011, 124(3): 311-320.
[48]	John PCS, Hirota T, Kay SA, Doyle III FJ. Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock. Proc Natl Acad Sci USA, 2014, 111(5): 2040-2045.
[49]	Mehra A, Baker CL, Loros JJ, Dunlap JC. Post-translational modifications in circadian rhythms. Trends Biochem Sci, 2009, 34(10): 483-490.
[50]	Seo PJ, Mas P. Multiple layers of posttranslational regulation refine circadian clock activity inArabidopsis. Plant Cell, 2014, 26(1): 79-87.
[51]	Yue M , Yang Y , Guo GX , Qin XM. Genetic and epigeneticregulations of mammalian circadian rhythms. Hereditas (Beijing), 2017, 39( 12): 1122- 1137.
[51]	岳敏, 杨禹, 郭改丽, 秦曦明. 哺乳动物生物钟的遗传和表观遗传研究进展. 遗传, 2017, 39( 12): 1122- 1137.
[52]	O’Neill JS, Reddy AB. Circadian clocks in human red blood cells. Nature, 2011, 469(7331): 498-503.
[53]	Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin XM, Xu Y, Pan M, Valekunja UK, Feeney KA, Maywood ES, Hastings MH, Baliga NS, Merrow M, Millar AJ, Johnson CH, Kyriacou CP, O'Neill JS, Reddy AB. Peroxiredoxins are conserved markers of circadian rhythms. Nature, 2012, 485(7399): 459-464.
[54]	Thaiss CA, Levy M, Korem T, Dohnalová L, Shapiro H, Jaitin DA, David E, Winter DR, Gury-BenAri M, Tatirovsky E, Tuganbaev T, Federici S, Zmora N, Zeevi D, Dori-Bachash M, Pevsner-Fischer M, Kartvelishvily E, Brandis A, Harmelin A, Shibolet O, Halpern Z, Honda K, Amit I, Segal E, Elinav E. Microbiota diurnal rhythmicity programs host transcriptome oscillations. Cell, 2016, 167 (6): 1495-1510.e1412.
[55]	Wang W, Barnaby JY, Tada Y, Li HR, T?r M, Caldelari D, Lee DU, Fu XD, Dong X. Timing of plant immune responses by a central circadian regulator. Nature, 2011, 470(7332): 110-114.
[56]	Zhang C, Xie QG, Anderson RG, Ng G, Seitz NC, Peterson T, McClung CR, McDowell JM, Kong DD, Kwak JM, Lu H. Crosstalk between the circadian clock and innate immunity in Arabidopsis. PLoS Pathog, 2013, 9(6): e1003370.
[57]	Atamian HS, Creux NM, Brown EA, Garner AG, Blackman BK, Harmer SL. Circadian regulation of sunflower heliotropism, floral orientation, and pollinator visits. Science, 2016, 353(6299): 587-590.
[58]	Reppert SM, Guerra PA, Merlin C. Neurobiology of monarch butterfly migration. Annu Rev Entomol, 2016, 61: 25-42.
[59]	Zhan S, Merlin C, Boore JL, Reppert SM. The monarch butterfly genome yields insights into long-distance migration. Cell, 2011, 147(5): 1171-1185.
[60]	Dakhiya Y, Hussien D, Fridman E, Kiflawi M, Green RM. Correlations between circadian rhythms and growth in challenging environments. Plant Physiol, 2017, 173(3): 1724-1734.
[61]	Bendix C, Marshall CM, Harmon FG. Circadian clock genes universally control key agricultural traits. Mol Plant, 2015, 8(8): 1135-1152.
[62]	Xie QG , Xu XD. Circadian clock and the control of key agronomic traits in higher plants. Chin Bull Life Sci, 2015, 27( 11): 1336- 1344.
[62]	谢启光, 徐小冬. 植物生物钟与关键农艺性状调控. 生命科学, 2015, 27( 11): 1336- 1344.
[63]	Ni ZF, Kim ED, Ha M, Lackey E, Liu JX, Zhang YR, Sun QX, Chen ZJ. Altered circadian rhythms regulate growth vigour in hybrids and allopolyploids. Nature, 2009, 457(7227): 327-331.
[64]	Xie QG, Lou P, Hermand V, Aman R, Park HJ, Yun DJ, Kim WY, Salmela MJ, Ewers BE, Weinig C, Khan SL, Schaible DLP, McClung CR. Allelic polymorphism ofGIGANTEA is responsible for naturally occurring variation in circadian period in Brassica rapa. Proc Natl Acad Sci USA, 2015, 112(12): 3829-3834.
[65]	Goodspeed D, Liu JD, Chehab EW, Sheng ZJ, Francisco M, Kliebenstein DJ, Braam J. Postharvest circadian entrainment enhances crop pest resistance and phytochemical cycling. Curr Biol, 2013, 23(13): 1235-1241.
[66]	Lu SJ, Zhao XH, Hu YL, Liu SL, Nan HY, Li XM, Fang C, Cao D, Shi XY, Kong LP, Su T, Zhang FG, Li SC, Wang Z, Yuan XH, Cober ER, Weller JL, Liu BH, Hou XL, Tian ZX, Kong FJ. Natural variation at the soybean J locus improves adaptation to the tropics and enhances yield. Nat Genet, 2017, 49(5): 773-779.
[67]	Han F. Circadian rhythm sleep disorders. Chin Bull Life Sci, 2015, 27( 11): 1448- 1454.
[67]	韩芳. 昼夜节律性睡眠障碍. 生命科学, 2015, 27( 11): 1448- 1454.
[68]	Sato S, Solanas G, Peixoto FO, Bee L, Symeonidi A, Schmidt MS, Brenner C, Masri S, Benitah SA, Sassone- Corsi P. Circadian reprogramming in the liver identifies metabolic pathways of aging. Cell, 2017, 170(4): 664- 677.e611.
[69]	Musiek ES, Xiong DD, Holtzman DM. Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease. Exp Mol Med, 2015, 47(3): e148.
[70]	Kelleher FC, Rao A, Maguire A. Circadian molecular clocks and cancer. Cancer Lett, 2014, 342(1): 9-18.
[71]	Roenneberg T, Merrow M. The circadian clock and human health. Curr Biol, 2016, 26(10): R432-R443.
[72]	Ni YH , Wu T , Wang L , Xia LQ , Zhang DP , Fu ZW. Advances in interactions between glucocorticoid hormones and circadian gene expression. Hereditas (Beijing), 2008, 30( 2): 135- 141.
[72]	倪银华, 吴涛, 王露, 夏李群, 张丹萍, 傅正伟. 肾上腺糖皮质激素与生物钟基因表达调控的相关研究进展. 遗传, 2008, 30( 2): 135- 141.
[73]	Janich P, Meng QJ, Benitah SA. Circadian control of tissue homeostasis and adult stem cells. Curr Opin Cell Biol, 2014, 31: 8-15.
[74]	Solanas G, Peixoto FO, Perdiguero E, Jardí M, Ruiz-Bonilla V, Datta D, Symeonidi A, Castellanos A, Welz PS, Caballero JM, Sassone-Corsi P, Mu?oz-Cánoves P, Benitah SA. Aged stem cells reprogram their daily rhythmic functions to adapt to stress. Cell, 2017, 170(4): 678-692.e620.
[75]	Cadenas C, van de Sandt L, Edlund K, Lohr M, Hellwig B, Marchan R, Schmidt M, Rahnenführer J, Oster H, Hengstler JG. Loss of circadian clock gene expression is associated with tumor progression in breast cancer. Cell Cycle, 2014, 13(20): 3282-3291.
[76]	Blask DE, Dauchy RT, Dauchy EM, Mao LL, Hill SM, Greene MW, Belancio VP, Sauer LA, Davidson L. Light exposure at night disrupts host/cancer circadian regulatory dynamics: impact on the Warburg effect, lipid signaling and tumor growth prevention. PLoS One, 2014, 9(8): e102776.
[77]	Smolensky MH, Sackett-Lundeen LL, Portaluppi F. Nocturnal light pollution and underexposure to daytime sunlight: complementary mechanisms of circadian disruption and related diseases. Chronobiol Int, 2015, 32(8): 1029-1048.
[78]	Labrecque N, Cermakian N. Circadian clocks in the immune system. J Biol Rhythms, 2015, 30(4): 277-290.
[79]	Scheiermann C, Kunisaki Y, Frenette PS. Circadian control of the immune system. Nat Rev Immunol, 2013, 13(3): 190-198.
[80]	Welsh DK, Takahashi JS, Kay SA. Suprachiasmatic nucleus: cell autonomy and network properties. Annu Rev Physiol, 2010, 72: 551-577.
[81]	Mieda M, Ono D, Hasegawa E, Okamoto H, Honma KI, Honma S, Sakurai T. Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior rhythm. Neuron, 2015, 85(5): 1103-1116.

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

时间生物学—2017年诺贝尔生理或医学奖解读

Chronobiology—2017 Nobel Prize in Physiology or Medicine

RichHTML

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 6

编辑推荐

Metrics

[1]	张晴,平杰,张昊翔,康波,李元丰,周钢桥. MKL1基因多态性与高原环境适应性的遗传关联研究[J]. 遗传, 2019, 41(7): 634-643.
[2]	李佳,刘运华,张余,陈晨,余霞,余舜武. 干旱对水稻生物钟基因和干旱胁迫响应基因每日节律性变化的影响[J]. 遗传, 2017, 39(9): 837-846.
[3]	岳敏, 杨禹, 郭改丽, 秦曦明. 哺乳动物生物钟的遗传和表观遗传研究进展[J]. 遗传, 2017, 39(12): 1122-1137.
[4]	吕垣澄, 吴晓晖. 动物隐花色素研究进展[J]. 遗传, 2014, 36(9): 864-870.
[5]	王明勇，黄国栋，王晗. 斑马鱼生物钟研究进展[J]. 遗传, 2012, 34(9): 1133-1143.
[6]	倪银华，吴涛，王露，夏李群，张丹萍，傅正伟. 肾上腺糖皮质激素与生物钟基因表达调控的相关研究进展[J]. 遗传, 2008, 30(2): 135-141.