动物隐花色素研究进展

doi:10.3724/SP.J.1005.2014.0864

遗传 ›› 2014, Vol. 36 ›› Issue (9): 864-870.doi: 10.3724/SP.J.1005.2014.0864

动物隐花色素研究进展

吕垣澄, 吴晓晖

复旦大学生命科学学院,遗传工程国家重点实验室及发育与疾病国际联合研究中心,遗传与发育协同创新中心,上海 200433

收稿日期:2014-05-23 出版日期:2014-09-20 发布日期:2014-09-20
通讯作者: 吴晓晖,教授,博士生导师,研究方向：发育遗传学。E-mail: xiaohui_wu@fudan.edu.cn E-mail:yuanchenglu26@gmail.com
作者简介:吕垣澄,本科生,专业方向：发育遗传学。
基金资助:
秦惠莙与李政道中国大学生见习进修基金,国家基金委人才培养基金和国家拔尖人才培养计划资助

Research progresses in animal cryptochromes

Yuancheng Lu, Xiaohui Wu

State Key Laboratory of Genetic Engineering and National Center for International Research of Development and Disease, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China

Received:2014-05-23 Online:2014-09-20 Published:2014-09-20

摘要/Abstract

摘要： 动物隐花色素(Cryptochrome)分为I型和II型,对生物钟的调控作用广为人知。I型隐花色素可以感受光信号而介导转录抑制物降解,II型隐花色素不需感受光而直接充当转录抑制物。近期研究发现,动物隐花色素还参与免疫应答和糖代谢,并为果蝇等动物光信号诱导的化学磁感知所必需。对动物隐花色素的进一步研究将增加对动物感知磁场过程的了解,也将帮助开发针对糖尿病等疾病的干预方法。文章重点综述了动物隐花色素的克隆与表达、结构特征、生理功能及作用机制,为这一领域的研究提供参考。

关键词: 动物, 隐花色素, 生物钟, 化学磁感知

Abstract: Animal cryptochromes are widely known to regulate circadian clock and can be divided into two types. Type I cryptochromes receive light to initiate the degradation of transcriptional inhibitors, whereas type II cryptochromes directly act as light-irresponsive transcriptional inhibitors. Recent studies reveal that animal cryptochromes also have functions in immune response and carbohydrate metabolism, and are required in light-induced chemical magnetoreception in animals like Drosophila. The further researches on animal cryptochromes will improve our understanding of magnetoreception and aid development of therapeutic treatment of diseases such as diabetes. In this review, we summarize the research progresses of animal cryptochromes, with an emphasis on its cloning, expression, and structural and functional studies.

Key words: animal, cryptochrome, circadian clock, chemical magnetoreception

吕垣澄, 吴晓晖. 动物隐花色素研究进展[J]. 遗传, 2014, 36(9): 864-870.

Yuancheng Lu, Xiaohui Wu. Research progresses in animal cryptochromes[J]. HEREDITAS(Beijing), 2014, 36(9): 864-870.

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动物隐花色素研究进展

Research progresses in animal cryptochromes

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