遗传 ›› 2011, Vol. 33 ›› Issue (3): 213-218.doi: 10.3724/SP.J.1005.2011.00213

• 综述 • 上一篇    下一篇

CRISPR-Cas系统与细菌和噬菌体的共进化

李铁民, 杜波   

  1. 辽宁大学生命科学院, 沈阳 110036
  • 收稿日期:2010-05-18 修回日期:2010-07-28 出版日期:2011-03-20 发布日期:2011-02-23
  • 通讯作者: 李铁民 E-mail:tieminli@lnu.edu.cn
  • 基金资助:

    沈阳市科技局计划项目(编号:1091187-1-00)资助

CRISPR-Cas system and coevolution of bacteria and phages

LI Tie-Min, DU Bo   

  1. College of Life Science, Liaoning University, Shenyang 110036, China
  • Received:2010-05-18 Revised:2010-07-28 Online:2011-03-20 Published:2011-02-23
  • Contact: DU Bo E-mail:tieminli@lnu.edu.cn

摘要: 细菌在适应噬菌体攻击的过程中, 进化了多种防御系统, 噬菌体在细菌的选择压力下, 也在不断进化反防御策略, 双方的这种进化关系与发生机制一直尚不完全清楚。近年在细菌和古细菌中发现一种新的免疫防御系统, 即CRISPR-Cas(clustered regularly interspaced short palindromic repeats-CRISPR-associated system)系统。在对其功能和作用机制深入研究的同时, 也不断地揭示了细菌和噬菌体之间的共进化关系。为此, 文章在介绍原核细胞中CRISPR-Cas系统介导的免疫机制基础上, 重点综述了CRISPR系统在细菌和噬菌体进化中的作用。

关键词: CRISPR, CRISPR-Cas系统, 噬菌体, 共进化, 免疫防御

Abstract: In response to the challenge from phages, bacteria evolve a number of defense systems against phage invasion. Meanwhile, the phages evolve multiple counter-defense mechanism as well under the selection pressure from bacteria. The evolution relationship between bacteria and phages, as well as the functional mechanism, still remains to be uncovered. A novel immune system, CRISPR-Cas system, has been found in bacteria and archaea recently. With deeply research of the function and mechanism of CRISPR-Cas system, the coevolution relationship between bacteria and phages is becoming clear. In this review, the mechanism of CRISPR-Cas system-mediated immunity in prokaryotes is introduced. In particular, the progress on the role of CRISPR in the coevolution of bacteria and phage is reviewed.

Key words: CRISPR, CRISPR-Cas system, phage, coevolution, immune defense