表皮生长因子受体与肺脏发育的关系

doi:10.3724/SP.J.1005.2012.00027

遗传 ›› 2012, Vol. 34 ›› Issue (1): 27-32.doi: 10.3724/SP.J.1005.2012.00027

表皮生长因子受体与肺脏发育的关系

李海静^1,2, 刘岩² , 郝海生², 杜卫华², 赵学明², 王栋², 秦彤², 马友记¹, 朱化彬²

1. 甘肃农业大学动物科学技术学院, 兰州 730070 2. 中国农业科学院北京畜牧兽医研究所, 北京 100193

收稿日期:2011-04-27 修回日期:2011-05-18 出版日期:2012-01-20 发布日期:2012-01-25
通讯作者: 朱化彬 E-mail:hubinzhu@yahoo.com.cn
基金资助:
转基因重大专项(编号：2009ZX08011-031B和2009ZX08010-015B)和基本科研业务费(编号：2011cj-11)资助

Relationship of epidermal growth factor receptor in lung development

LI Hai-Jing^1,2, LIU Yan², HAO Hai-Sheng², DU Wei-Hua², ZHAO Xue-Ming², WANG Dong², QIN Tong², MA You-Ji¹, ZHU Hua-Bin²

1. College of Animal Science & Technology, Gansu Agricultural University, Lanzhou 730070, China 2. Institute of Animal Sciences, Chinese Academy of Agricaltural Sciences, Beijing 100193, China

Received:2011-04-27 Revised:2011-05-18 Online:2012-01-20 Published:2012-01-25

摘要/Abstract

摘要： 表皮生长因子受体(Epidermal growth factor receptor, EGFR)是一种跨膜蛋白受体, 是ErbB家族成员之一, 具有酪氨酸激酶活性。EGFR与相应的配体结合引起EGFR形成同源或异源二聚体启动胞内信号转导, 激活下游多种信号转导途径, 产生生物学效应, RAS/RAF/MEK/ERK通路与细胞增殖、分化和凋亡有关; PI3K/PDK1/ AKT通路与细胞的迁移和粘附有关。EGFR能促进肺泡II型上皮细胞的成熟和肺表面活性物质的合成、分泌。EGFR对哺乳动物肺脏的作用呈现时空效应及剂量依赖效应, EGFR的下调表达则会引起肺脏发育不成熟; 而EGFR过度表达促进肺肿瘤细胞的增殖、侵袭和转移。文章综述了EGFR及其调节信号通路的研究进展, 以及EGFR与动物肺脏发育不成熟和肺癌之间的关系。

关键词: EGFR, 肺泡Ⅱ型上皮细胞, 肺脏表面活性物质, 肺癌

Abstract: The epidermal growth factor receptor (EGFR), a transmembrane protein receptor, is a member of ErbB family with signal-transducing tyrosine kinase activity. After combined with the ligand, EGFR homologous or heterologous dimers are formed to induce intracellular signal transduction, activate downstream signal transduction pathways, and then produce a series of biological effects. RAF/MEK/RAS/ERK pathway is relevant to cell proliferation, differentiation and apoptosis; while PDK1/AKT /PI3K pathway is involved in cell migration and adhesion. EGFR can promote the maturity of pulmonary type II epithelial cells and the synthesis and secretion of pulmonary surfactant. EGFR shows the effect on mammal lungs in a time-space and dose-dependent manner. The down-regulated expression of it will lead to immature lung development, while the over-expression can promote the cell proliferation, invasion and metastasis of the lung cancer cells. This paper reviewed advances in the study for EGFR and its signal pathway, as well as the relationship among EGFR, atelectasis and lung cancer.

Key words: epidermal growth factor receptor, typeⅡalveolar cells, surfactant associated protein, lung cancer

李海静，刘岩，郝海生，杜卫华，赵学明，王栋，秦彤，马友记，朱化彬. 表皮生长因子受体与肺脏发育的关系[J]. 遗传, 2012, 34(1): 27-32.

LI Hai-Jing, LIU Yan, HAO Hai-Sheng, DU Wei-Hua, ZHAO Xue-Ming, WANG Dong, QIN Tong, MA You-Ji, ZHU Hua-Bin. Relationship of epidermal growth factor receptor in lung development[J]. HEREDITAS, 2012, 34(1): 27-32.

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表皮生长因子受体与肺脏发育的关系

Relationship of epidermal growth factor receptor in lung development

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