微RNA通过调节上皮间质转化影响肿瘤转移

doi:10.3724/SP.J.1005.2014.0637

遗传 ›› 2014, Vol. 36 ›› Issue (7): 637-645.doi: 10.3724/SP.J.1005.2014.0637

微RNA通过调节上皮间质转化影响肿瘤转移

杨丽华^{1, 2}, 沈星凯¹, 李静秋^{1, 2}, 杨杰^{1, 2}, 乐燕萍^{1, 2}, 龚朝辉^{1, 2}

1. 宁波大学医学院生物化学与分子生物学研究所, 宁波 315211;
2. 浙江省病理生理学技术研究重点实验室, 宁波 315211

收稿日期:2014-01-16 出版日期:2014-07-20 发布日期:2014-06-23
通讯作者: 龚朝辉, 博士, 教授, 研究方向：肿瘤分子生物学。E-mail: zhaohui@ncri.org.cn
作者简介:杨丽华, 硕士研究生, 专业方向：肿瘤分子生物学。Tel: 0574-87600754; E-mail: lihuayang@ncri.org.cn
基金资助:
浙江省高等学校中青年学科带头人学术攀登项目(编号：pd2013103), 浙江省科技厅公益技术应用研究项目(编号：2013C37029), 宁波市科技创新团队项目(编号：2011B82014), 宁波大学创优秀硕士论文培育基金项目(编号：PY2012010)和宁波大学王宽诚教育基金资助

MicroRNAs affect tumor metastasis through regulating epithelial- mesenchymal transition

Lihua Yang^{1, 2}, Xingkai Shen¹, Jingqiu Li^{1, 2}, Jie Yang^{1, 2}, Yanping Le^{1, 2}, Zhaohui Gong^{1, 2}

1. Institute of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Ningbo 315211, China;
2. Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China

Received:2014-01-16 Online:2014-07-20 Published:2014-06-23

摘要/Abstract

摘要： 肿瘤细胞向远处转移受多因素调控, 涉及多个基因, 需要经历一系列连续的、可选择的级联事件。上皮间质转化(Epithelial-mesenchymal transition, EMT)是肿瘤细胞转移中的关键步骤, 但肿瘤发生 EMT的机制至今尚不完全明确。微RNA (MicroRNA, miRNA)是一类内源性、非编码小分子RNA, 可在转录后水平负调控EMT相关基因的表达, 在肿瘤转移中发挥重要作用。文章主要就EMT与肿瘤转移的关系、影响EMT的转录因子, 以及miRNA通过靶向EMT相关的转录因子影响肿瘤转移等方面进行了综述。

关键词: 微RNA, 肿瘤转移, 上皮间质转化

Abstract: Distant metastasis of tumor cell is a series of continuous, selectable cascades of events regulated by multiple factors and genes. Epithelial-mesenchymal transition (EMT) is a critical step during cancer metastasis. However, the mechanism of EMT in tumor is not yet fully elucidated. MicroRNAs (miRNAs) are a class of non-coding small endogenous RNAs that negatively regulate EMT-related genes at the post-transcriptional level and play critical roles in cancer metastasis. This review mainly focuses on the topics that include the relationship of EMT and tumor metastasis, transcription factors involved in EMT, and the effect of miRNAs on tumor metastasis by targeting the EMT-related transcription factors.

Key words: microRNAs, tumor metastasis, epithelial-mesenchymal transition

杨丽华, 沈星凯, 李静秋, 杨杰, 乐燕萍, 龚朝辉. 微RNA通过调节上皮间质转化影响肿瘤转移[J]. 遗传, 2014, 36(7): 637-645.

Lihua Yang, Xingkai Shen, Jingqiu Li, Jie Yang, Yanping Le, Zhaohui Gong. MicroRNAs affect tumor metastasis through regulating epithelial- mesenchymal transition[J]. HEREDITAS(Beijing), 2014, 36(7): 637-645.

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微RNA通过调节上皮间质转化影响肿瘤转移

MicroRNAs affect tumor metastasis through regulating epithelial- mesenchymal transition

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