竞争性内源RNA的生物学功能及其调控

doi:10.16288/j.yczz.15-073

遗传 ›› 2015, Vol. 37 ›› Issue (8): 756-764.doi: 10.16288/j.yczz.15-073

竞争性内源RNA的生物学功能及其调控

李静秋^{1, 2}, 杨杰^{1, 2}, 周平^{1, 2}, 乐燕萍^{1, 2}, 龚朝辉^{1, 2}

1. 宁波大学医学院生物化学与分子生物学研究所,宁波 315211;
2. 浙江省病理生理学技术研究重点实验室,宁波 315211

收稿日期:2015-02-09 修回日期:2015-04-07 出版日期:2015-08-20 发布日期:2015-08-20
通讯作者: 龚朝辉,博士,教授,研究方向：肿瘤分子生物学。E-mail: zhaohui@ncri.org.cn
作者简介:李静秋,硕士研究生,专业方向：肿瘤分子生物学。Tel：0574-87600754;E-mail: jqli@ncri.org.cn
基金资助:
浙江省自然科学基金项目(编号：LY15C060003),浙江省高等学校中青年学科带头人学术攀登项目(编号：pd2013103),浙江省科技厅公益技术应用研究项目(编号：2013C37029),宁波市科技创新团队项目(编号：2011B82014),宁波市社发攻关项目(编号：2014C50058)和宁波大学王宽诚教育基金资助

The biological functions and regulations of competing endogenous RNA

Jingqiu Li^{1, 2}, Jie Yang^{1, 2}, Ping Zhou^{1, 2}, Yanping Le^{1, 2}, Zhaohui Gong^{1, 2}

1. Institute of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, Ningbo 315211, China;
2. Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China

Received:2015-02-09 Revised:2015-04-07 Online:2015-08-20 Published:2015-08-20

摘要/Abstract

摘要： 最新研究表明,RNA之间可以通过竞争结合共同的microRNA反应元件(microRNA response element, MRE)实现相互调节,这种调控模式构成竞争性内源RNA(Competing endogenous RNA, ceRNA)。已发现的ceRNA包括蛋白编码mRNA和非编码RNA,其中后者包括假基因转录物、长链非编码RNA(Long non-coding RNA, lncRNA)、环状RNA(Circular RNA, circRNA)等。文章主要从ceRNA分类的角度,阐述各类ceRNA构成的调控网络发挥的生物学功能在病理和生理相关过程中的作用,以及可能影响ceRNA调控有效性的因素。

关键词: 竞争性内源RNA, 微RNA反应元件, 假基因, 长链非编码RNA, 环状RNA

Abstract: Recent studies demonstrate that RNA species could regulate each other by competing for shared microRNA response elements (MREs). This regulatory model is called competing endogenous RNA (ceRNA). Currently, the identified ceRNAs cover coding and non-coding RNAs. The latter includes pseudogene transcripts, long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and so on. In this review, we summarize the biological functions of regulatory networks consisting of various types of ceRNAs and their roles in the pathological and physiological processes. Additionally, several factors that may regulate ceRNAs were discussed.

Key words: competing endogenous RNA, microRNA response element, pseudogene, long non-coding RNA, circular RNA

李静秋, 杨杰, 周平, 乐燕萍, 龚朝辉. 竞争性内源RNA的生物学功能及其调控[J]. 遗传, 2015, 37(8): 756-764.

Jingqiu Li, Jie Yang, Ping Zhou, Yanping Le, Zhaohui Gong. The biological functions and regulations of competing endogenous RNA[J]. HEREDITAS(Beijing), 2015, 37(8): 756-764.

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竞争性内源RNA的生物学功能及其调控

The biological functions and regulations of competing endogenous RNA

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