睾丸发育和精子生成相关miRNA研究进展

doi:10.3724/SP.J.1005.2014.0646

遗传 ›› 2014, Vol. 36 ›› Issue (7): 646-654.doi: 10.3724/SP.J.1005.2014.0646

睾丸发育和精子生成相关miRNA研究进展

冉茂良¹, 陈斌¹, 尹杰^{2, 3}, 杨岸奇¹, 蒋明¹

1. 湖南农业大学动物科学技术学院, 长沙 410128;
2. 中国科学院亚热带农业生态研究所, 中国科学院亚热带农业生态过程重点实验室, 湖南省畜禽健康养殖工程技术中心, 农业部中南动物营养与饲料科学观测实验站, 长沙 410125;
3. 中国科学院研究生院, 北京 100049

收稿日期:2013-11-29 出版日期:2014-07-20 发布日期:2014-06-23
通讯作者: 陈斌, 博士, 教授, 博士生导师, 研究方向：猪的遗传育种。E-mail: chenbin7586@126.com
作者简介:冉茂良, 博士研究生, 专业方向：猪的遗传育种。E-mail: ranmaoliang0903@126.com
基金资助:
国家现代农业产业技术体系建设专项资金(编号：CARS-36)资助

Advances in miRNA research related to testis development and spermatogenesis

Maoliang Ran¹, Bin Chen¹, Jie Yin^{2, 3}, Anqi Yang¹, Ming Jiang¹

1. College of Animal Science & Technology, Hunan Agricultural University, Changsha 410128, China;
2. Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center of Healthy Livestock and Poultry, Key Laboratory of Agroecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;
3. University of the Chinese Academy of Sciences, Beijing 100049, China

Received:2013-11-29 Online:2014-07-20 Published:2014-06-23

摘要/Abstract

摘要： MicroRNA(miRNA)是一类长约22nt的非编码小RNA, 广泛存在于各种生物中, 调节生物体生长、发育和凋亡等过程。研究表明, miRNA在人和动物睾丸发育及精子生成等过程也起着重要的调控作用。但miRNA在不同种属的睾丸组织及其不同发育时间段均存在特异性表达。此外, miRNA在动物精子生成过程中也存在时空特异性。文章综述了睾丸发育和精子生成过程中miRNA的差异性表达、表达调控以及一些miRNA对精子生成的调节作用, 旨在为睾丸miRNA的进一步研究提供参考, 为利用miRNA调控和促进种公畜精液品质提供研究思路。

关键词: miRNA, 睾丸发育, 精子生成

Abstract: MicroRNA (miRNA), a class of non-coding RNA (about 22 nt), widely exists in different organisms and plays an important role in regulating cell growth, development, and apoptosis. Recently, various studies have demonstrated that miRNA also serves as a key mediator during testis development and spermatogenesis both in human beings and animals. However, the expression of miRNA in different testis from different species showed significant differences. Meanwhile, it also showed different expression patterns in different spermatogenesis stages. In this review, we summarize different miRNA expression patterns during testis development, spermatogenesis, as well as their roles in regulating spermatogenesis, which provids insight into the further research on miRNA in testis, and ideas for regulating and improving animal sperm quality by using miRNA.

Key words: miRNA, development of testis, spermatogenesis

冉茂良, 陈斌, 尹杰, 杨岸奇, 蒋明. 睾丸发育和精子生成相关miRNA研究进展[J]. 遗传, 2014, 36(7): 646-654.

Maoliang Ran, Bin Chen, Jie Yin, Anqi Yang, Ming Jiang. Advances in miRNA research related to testis development and spermatogenesis[J]. HEREDITAS(Beijing), 2014, 36(7): 646-654.

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睾丸发育和精子生成相关miRNA研究进展

Advances in miRNA research related to testis development and spermatogenesis

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