睾丸发育和精子生成相关miRNA研究进展

doi:10.3724/SP.J.1005.2014.0646

遗传 ›› 2014, Vol. 36 ›› Issue (7): 646-654.doi: 10.3724/SP.J.1005.2014.0646

睾丸发育和精子生成相关miRNA研究进展

冉茂良¹, 陈斌¹, 尹杰^{2, 3}, 杨岸奇¹, 蒋明¹

1. 湖南农业大学动物科学技术学院, 长沙 410128;
2. 中国科学院亚热带农业生态研究所, 中国科学院亚热带农业生态过程重点实验室, 湖南省畜禽健康养殖工程技术中心, 农业部中南动物营养与饲料科学观测实验站, 长沙 410125;
3. 中国科学院研究生院, 北京 100049

收稿日期:2013-11-29 出版日期:2014-07-20 发布日期:2014-06-23
通讯作者: 陈斌, 博士, 教授, 博士生导师, 研究方向：猪的遗传育种。E-mail: chenbin7586@126.com
作者简介:冉茂良, 博士研究生, 专业方向：猪的遗传育种。E-mail: ranmaoliang0903@126.com
基金资助:
国家现代农业产业技术体系建设专项资金(编号：CARS-36)资助

Advances in miRNA research related to testis development and spermatogenesis

Maoliang Ran¹, Bin Chen¹, Jie Yin^{2, 3}, Anqi Yang¹, Ming Jiang¹

1. College of Animal Science & Technology, Hunan Agricultural University, Changsha 410128, China;
2. Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center of Healthy Livestock and Poultry, Key Laboratory of Agroecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;
3. University of the Chinese Academy of Sciences, Beijing 100049, China

Received:2013-11-29 Online:2014-07-20 Published:2014-06-23

摘要/Abstract

摘要： MicroRNA(miRNA)是一类长约22nt的非编码小RNA, 广泛存在于各种生物中, 调节生物体生长、发育和凋亡等过程。研究表明, miRNA在人和动物睾丸发育及精子生成等过程也起着重要的调控作用。但miRNA在不同种属的睾丸组织及其不同发育时间段均存在特异性表达。此外, miRNA在动物精子生成过程中也存在时空特异性。文章综述了睾丸发育和精子生成过程中miRNA的差异性表达、表达调控以及一些miRNA对精子生成的调节作用, 旨在为睾丸miRNA的进一步研究提供参考, 为利用miRNA调控和促进种公畜精液品质提供研究思路。

关键词: miRNA, 睾丸发育, 精子生成

Abstract: MicroRNA (miRNA), a class of non-coding RNA (about 22 nt), widely exists in different organisms and plays an important role in regulating cell growth, development, and apoptosis. Recently, various studies have demonstrated that miRNA also serves as a key mediator during testis development and spermatogenesis both in human beings and animals. However, the expression of miRNA in different testis from different species showed significant differences. Meanwhile, it also showed different expression patterns in different spermatogenesis stages. In this review, we summarize different miRNA expression patterns during testis development, spermatogenesis, as well as their roles in regulating spermatogenesis, which provids insight into the further research on miRNA in testis, and ideas for regulating and improving animal sperm quality by using miRNA.

Key words: miRNA, development of testis, spermatogenesis

冉茂良, 陈斌, 尹杰, 杨岸奇, 蒋明. 睾丸发育和精子生成相关miRNA研究进展[J]. 遗传, 2014, 36(7): 646-654.

Maoliang Ran, Bin Chen, Jie Yin, Anqi Yang, Ming Jiang. Advances in miRNA research related to testis development and spermatogenesis[J]. HEREDITAS(Beijing), 2014, 36(7): 646-654.

参考文献

[1] RC, Feinbaum RL, Ambros V. The C . elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell , 1993, 75(5): 843-854.
[2] BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans . Nature , 2000, 403(6772): 901-906.
[3] 董园园, 李海燕, 李校堃. MicroRNAs的分子进化与调控机制. 遗传, 2010, 32(9): 874-880.
[4] 孟丽军, 宋亚娟, 刘美玲, 张秀军. 小RNA分子与精子发生调控. 遗传, 2011, 33(1): 9-16.
[5] 刘志红, 王志新, 赵濛, 俎红丽, 李金泉. MiRNA在调控皮肤和毛囊发育中的作用. 遗传, 2013, 35(9): 1087-1094.
[6] 杨建香, 李真, 刘红云, 刘建新. 乳腺发育及泌乳相关miRNA研究进展. 遗传, 2013, 35(6): 695-702.
[7] 宋沁馨, 周国华. MicroRNA定量检测方法的研究进展. 遗传, 2010, 32(1): 31-40.
[8] CG, Calin GA, Meloon B, Gamliel N, Sevignani C, Ferracin M, Dumitru CD, Shimizu M, Croce CM. An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proc Natl Acad Sci USA , 2004, 101(26): 9740-9744.
[9] T, Takizawa T, Luo SS, Ishibashi O, Kawahigashi Y, Mizuguchi Y, Ishikawa T, Mori M, Kanda T, Goto T, Takizawa T. MicroRNA(miRNA) cloning analysis reveals sex differences in miRNA expression profiles between adult mouse testis and ovary. Reproduction , 2008, 136(6): 811-822.
[10] J, Ju Z, Li Q, Hou Q, Wang C, Li J, Li R, Wang L, Sun T, Hang S, Gao Y, Hou M, Zhong J. Solexa sequencing of novel and differentially expressed microRNAs in testicular and ovarian tissues in holstein Cattle. Int J Biol Sci , 2011, 7(7): 1016-1026.
[11] J, Zhu H, Song W, Li M, Liu C, Li N, Tang F, Mu H, Liao M, Li X, Guan W, Li X, Hua J. Identification of conservative microRNAs in Saanen dairy goat testis through deep sequencing. Reprod Domest Anim , 2014, 49(1): 32-40.
[12] Q, Hua J, Wang L, Xu B, Zhang H, Ye N, Zhang ZQ, Yu DX, Cooke HJ, Zhang YW, Shi QH. MicroRNA and piRNA profiles in normal human testis detected by next generation equencing. PLoS O NE , 2013, 8(6): e66809.
[13] M, Backes C, Leidinger P, Keller A, Lubbad AM, Hammadeh M, Meese E. MicroRNA expression profiles in human testicular tissues of infertile men with different histopathologic patterns. Fertil Steril , 2014, 101(1): 78-86.
[14] ItmanC, MendisSH, LovelandKL. Activins and inhibins in mammalian testis development: new models, new insights. Mol Cell Endocrinol , 2012, 359(1-2): 66-77.
[15] N, Lu Y, Sun H, Tao D, Zhang S, Liu W, Ma Y. A microarray for microRNA profiling in mouse testis tissues. Reproduction , 2007, 134(1): 73-79.
[16] C, Sun B, Niu S, Yang R, Liu B, Lu C, Meng J, Qiu Z, Zhang L, Zhao Z. A comparative profile of the microRNA transcriptome in immature and mature porcine testes using Solexa deep sequencing. FEBS J , 2012, 279(6): 964-975.
[17] L, Ye L, Liu G, Shao G, Zheng R, Ren Z, Zuo B, Xu D, Lei M, Jiang S, Deng C, Xiong Y, Li F. Microarray-based approach identifies differentially expressed microRNAs in porcine sexually immature and mature testes. PLoS O NE , 2010, 5(8): e11744.
[18] KJ, da Silveira JC, Smith P, Anthony RV, Veeramachaneni DN, Winger QA, Bouma GJ. Expression of miRNAs in ovine fetal gonads: potential role in gonadal differentiation. Reprod Biol Endocrinol , 2011, 9(2): 1-11.
[19] J, Liu Q, Zhang W, Li J, Li Z, Tang Z, Li Y, Han C, Hall SH, Zhang Y. Comparative profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides. Acta Biochimica et Biophysica Sinica , 2010, 42(2): 145-153.
[20] ShenWJ, CortezY, TangX, LiuLF, KraemerFB, AzharS, Mari B. Hormonal regulation of microRNA expression in steroid producing cells of the ovary, testis and adrenal gland. PLoS O NE , 2013, 8(10): e78040.
[21] S, Chang YF, Buddavarapu KC, Chen HI, Shetty G, Wang H, Chen Y, Kumar TR, Rao MK, Lobaccaro JA. Androgen-responsive microRNAs in mouse sertoli cells. PLoS O NE , 2012, 7(7): e41146.
[22] GRTH/DDX25通过调节睾丸特异miRNA-469控制雄性生殖细胞的发育. 长春: 吉林大学, 2011: 39-85.
[23] L, Tsai-Morris CH, Sato H, Villar J, Kang JH, Zhang J, Dufau ML. Testis-specific miRNA-469 up-regulated in gonadotropin-regulated testicular RNA helicase (GRTH/ DDX25)-nullmice silences transition protein 2 and protamine 2 messages at sites within coding region: implications of its role in germ cell development. J Biol Chem , 2011, 286(52): 44306-443018.
[24] Q, Song R, Ortogero N, Zheng H, Evanoff R, Small CL, Griswold MD, Namekawa SH, Royo H, Turner JM, Yan W. The RNaseIII enzyme DROSHA is essential for microRNA production and spermatogenesis. J Biol Chem , 2012, 287(30): 25173-25190.
[25] H, Cao YX, Zhang XS, Liao WP, Yi YH, Lian J, Liu L, Huang HL, Liu WJ, Yin MM, Liang M, Shan G, Sun F. The targeting and functions of miRNA-383 are mediated by FMRP during spermatogenesis. Cell Death Dis , 2013, 4: e617.
[26] S, Karki N, Bhattacharya C, Zhu R, MacDuff DA, Stenglein MD, Schumacher AJ, Demorest ZL, Harris RS, Matin A, Aggarwal S. APOBEC3 inhibits DEAD-END function to regulate microRNA activity. BMC Mol Biol , 2013, 14: 16.
[27] Z, Goodyear SM, Rao S, WuX, Tobias JW, Avarbock MR, Brinster RL. MicroRNA-21 regulates the self-renewal of mouse spermatogonial stem cells. Proc Nat Acad Sci USA , 2011, 108(31): 12740-12745.
[28] RP, Kotaja N. Small RNAs in spermatogenesis. Mol Cell Endocrinol , 2014, 382(1): 498-508.
[29] I, Stauske M, Guan K. Spermatogonial stem cells. Regenerative Medicine , 2013, 219-249.
[30] BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell , 2003, 115(7): 787-798.
[31] K, Chuva de Sousa Lopes SM, Kaneda M, Tang F, Hajkova P, Lao K, O'Carroll D, Das PP, Tarakhovsky A, Miska EA, Surani MA, Heard E. MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis. PLoS O NE , 2008, 3(3): e1738.
[32] MH, Mitchell D, Evanoff R, Griswold MD. Expression of Mirlet7 family micro RNAs in response to retinoic acid-induced spermatogonial differentiation in mice. Biol Reprod , 2011, 85(1): 189-197.
[33] YH, Gupta MK, Shin JY, Uhm SJ, Lee HT. MicroRNA signature in testes-derived male germ-line stem cells. Mol Hum Reprod , 2010, 16(11): 804-810.
[34] MH, Mitchell DA, McGowan SD, Evanoff R, Griswold MD. Two miRNA clusters, Mir-17-92 (Mirc1) and Mir-106b-25 (Mirc3), are involved in the regulation of spermatogonial differentiation in mice. Biol Reprod , 2012, 86(3): 72.
[35] A, Brivanlou AH. A regulatory circuitry comprised of miR-302 and the transcription factors OCT4 and NR2F2 regulates human embryonic stem cell differentiation. EMBO J , 2011, 30(2): 237-248.
[36] Z, Pall E, Kerekes A, Pallinger E, Maraghechi P, Bosze Z, Gocza E. The miR-290-295 cluster promotes pluripotency maintenance by regulating cell cycle phase distribution in mouse embryonic stem cells. Differenti a tion , 2011, 81(1): 11-24.
[37] X, Li N, Liang S, Huang Q, Coukos G, Zhang L. Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells. J Biol Chem , 2010, 285(53): 41961-41971.
[38] SC, Roman SD, Nixon B, McLaughlin EA. miRNA and mammalian male germ cells. Hum Reprod Update , 2012, 18(1): 44-59.
[39] T, Suzuki A, Fujita Y, Yomogida K, Lomeli H, Asada N, Ikeuchi M, Nagy A, Mak TW, Nakano T. Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production. Development , 2003, 130(8): 1691-1700.
[40] GH, Klinger FG, Eskild W, Grotmol T, Haugen TB, De Felici M. Akt/PTEN signaling mediates estrogen-dependent proliferation of primordial germ cells in vitro. Mol Endocrinol , 2003, 17(12): 2630-2638.
[41] BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell , 2005, 120(1): 15-20.
[42] F, Allioli N, Lavial F, Chalmel F, Perrard MH, Durand P, Samarut J, Pain B, Rouault JP. Role of miR-34c microRNA in the late steps of spermatogenesis. RNA , 2010, 16(4): 720-731.
[43] JM, Payne CJ. MicroRNA 146 (miR146) modulates spermatogonial differentiation by retinoic acid in mice. Biol Reprod , 2013, 88(1): 15.
[44] QE, Racicot KE, Kaucher AV, Oatley MJ, Oatley JM. MicroRNAs 221 and 222 regulate the undifferentiated state in mammalian male germ cells. Development , 2013, 140(2): 280-290.
[45] J, Li D, Wang L, Wu J, Hu Y, Wang Z, Chen Y, Cao X, Jiang C, Yan W, Xu C. MicroRNA-449 and microRNA-34b/c function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway. J Biol Chem , 2012, 287(26): 21686-21698.
[46] Z, Raabe T, Hecht NB. MicroRNA Mirn122a reduces expression of theposttranscriptionally regulated germ cell transition protein 2 (Tnp2) messenger RNA (mRNA) by mRNA cleavage. Biol Reprod , 2005, 73(3): 427-433.
[47] E, Babak T, Chua G, Hughes T, Moens PB. miRNA and piRNA localization in the male mammalian meiotic nucleus. Chromosome Res , 2008, 16(2): 243-260.
[48] S, Meador C, Agarwal A. Small RNA in spermatogenesis and male infertility. Front Biosci ( Schol Ed ), 2012, 4: 1266-1274.
[49] S, Park C, Sanders KM, McCarrey JR, Yan W. Cloning and expression profiling of testis-expressed microRNAs. Dev Biol , 2007, 311(2): 592-602.
[50] Z, Jiang J, Kokkinaki M, Tang L, Zeng W, Gallicano I, Dobrinski I, Dym M. MiRNA-20 and mirna-106a regulate spermatogonial stem cell renewal at the post-transcriptional level via targeting STAT3 and Ccnd1 . Stem Cells , 2013, 31(10): 2205-2217.
[51] JW, Bao JQ, Wang L, Hu YQ, Xu C. MicroRNA-184 downregulates nuclear receptor corepressor 2 in mouse spermatogenesis. BMC Dev Biol , 2011, 11: 64.
[52] 腾鸿琦, 施珏平, 张彦定, 张明凤. Let-7 microRNA调控动物器官发育的研究进展. 生命科学, 2011, 23(4): 364-368.
[53] E, Viswanathan SR, Janas M, LaPierre RJ, Daley GQ, Sliz P, Gregory RI. Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem , 2008, 283(31): 21310-21314.

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睾丸发育和精子生成相关miRNA研究进展

Advances in miRNA research related to testis development and spermatogenesis

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