遗传 ›› 2003, Vol. 25 ›› Issue (3): 261-266.

• 论文 • 上一篇    下一篇

山东临朐胃癌高发人群和北京人群Lewis血型抗原相关SE基因多态性分析

姜劲迈;潘凯枫;马峻岭;宁涛;路桂荣;游伟程;柯杨 JIANG Jin-Mai;PAN Kai-Feng;MA Jun-Ling;NING Tao;LU Gui-Rong;YOU Wei-Cheng;KE Yang   

  1. 北京市肿瘤防治研究所,北京大学临床肿瘤学院,北京 100034 Beijing Institute for Cancer Research,School of Oncology,Peking University,Beijing 100034,China
  • 收稿日期:1900-01-01 出版日期:2003-06-10 发布日期:2003-06-10

Analysis of Polymorphisms on Lewis Blood Group Antigen Related SE Gene in the Populations in Shandong with High-risk of Gastric Cancer and Beijing

  • Received:1900-01-01 Online:2003-06-10 Published:2003-06-10

摘要: 为探讨宿主的遗传背景和幽门螺杆菌(Helicobacter pylori,H.pylori)相关胃癌的易感性之间的关系,本文采用PCR产物直接测序和PCR-RFLP的方法,检测142例山东临朐县胃癌高发人群个体(包括69例癌症患者和73例非癌个体)和93例北京正常对照个体SE基因多态性的分布特点。结果显示:sew/sew基因型在山东非癌个体和北京人群之间的分布差异具有统计学意义(P<0.01,OR=3.06,95% CI,1.28~7.30),sew/sew基因型在山东癌症病人和非癌个体之间分布频率无显著性差异,H.pylori感染状况与SE基因型的分布也无关联性。提示:sew/sew纯合突变在山东临朐人群中分布频率较高,可能为临朐人群的遗传标记之一。
Abstract:To study the relation between host genetic backgroud and the susceptibility to H.pylori associated gastric cancer,PCR-sequencing and PCR-RFLP were used to screen SECRETOR gene polymorphisms in 142 subjects including 69 cancer patients and 73 non-cancer individuals from high-risk area of gastric cancer in Shandong and 93 control individuals from Beijing.Results showed that the difference in sew/sew distribution between non-cancer individuals and Beijing population was significant(P<0.01,OR is 3.06,95% CI,1.28~7.30),but that between cancer patients and non-cancer individuals was not with significance.SE gene polymorphism was not relevant to H.pylori infection.We concluded that Shandong population from high-risk area of gastric cancer shared a high distribution of sew/sew genotype,which could be considered as one of the genetic markers.

关键词: 胃癌, Lewis血型抗原, SECRETOR基因, gastric cancer, 基因多态性
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