幽门螺杆菌毒力基因分型和宿主遗传多态性与胃病关系研究进展

doi:10.3724/SP.J.1005.2011.00558

遗传 ›› 2011, Vol. 33 ›› Issue (6): 558-566.doi: 10.3724/SP.J.1005.2011.00558

幽门螺杆菌毒力基因分型和宿主遗传多态性与胃病关系研究进展

张丽^{1, 2}, 王芃¹ , 魏莎莉² , 刘纯杰¹

1. 军事医学科学院生物工程研究所, 北京 100071 2. 重庆医科大学公共卫生学院, 重庆 400016

收稿日期:2010-09-30 修回日期:2011-01-14 出版日期:2011-06-20 发布日期:2011-06-25
通讯作者: 刘纯杰 E-mail:liucj@nic.bmi.ac.cn
基金资助:
“十一五”国家863“疫苗与抗体工程”重大项目基金(编号：2006AA02A219),“十一五”国家“艾滋病和病毒性肝炎等重大传染病防治”重大专项基金(编号：2008ZX10004-015)和“十一五”国家科技支撑计划项目基金(编号：2008BAI66B03)资助

Advances in relationship between gastric disease and polymorphisms in both helicobacter pylori virulence factors and host genetics

ZHANG Li^1,2, WANG Peng¹, WEI Sha-Li², LIU Chun-Jie¹

1. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing 100071, China 2. Public Healith of Chongqing Medical University, Chongqing 400016, China

Received:2010-09-30 Revised:2011-01-14 Online:2011-06-20 Published:2011-06-25
Contact: LIU Chun-Jie E-mail:liucj@nic.bmi.ac.cn

摘要/Abstract

摘要： 幽门螺杆菌(Helicobacter pylori)感染能导致慢性胃炎、消化性溃疡、胃粘膜相关的淋巴样组织 (Mu-cosa-associated lymphoid tissue, MALT)淋巴瘤和胃腺癌等疾病的发生。1994年世界卫生组织国际癌症研究中心(IARC)将H.pylori列为胃癌第一级因子。H.pylori感染引起的不同临床结局主要与H.pylori致病因子和宿主遗传易感性有关, 大部分重大疾病发生在特定的细菌毒力因子(如cagA, vacA)与易感宿主遗传背景共同存在时。文章综述了H.pylori菌株的毒力基因的分型和宿主的遗传多态性对胃病发生的影响。

关键词: 幽门螺杆菌, 宿主, 基因型, 基因多态性, 胃炎, 胃癌, 溃疡

Abstract: Helicobacter pylori infection may cause many gastric disease, such as peptic ulcers, chronic atrophic gastritis, gastric mucosa-associated lymphoid tissue lymphoma, and gastric cancer. The different clinical outcomes of Helicobacter pylori infection are related to H. pylori virulence factors and host gene polymorphism. H.pylori had been confirmed to be the class I carcinogen by the World Health Organization and International Agency for Research on Cancer Consensus Group (IARC) in1994. Most severe diseases always occur in the background that certain microbial virulence markers (e.g. cagA, vacA) and susceptible host genetic polymorphisms harboured together. Herein, we reviewed the association with H. pylori-related gastric diseases in relation to diffirent H. pylori types and the host polymorphisms.

Key words: Helicobacter pylori, genotype, gene polymorphism, gastritis, gastric cancer, ulcer, host

张丽，王芃，魏莎莉，刘纯杰. 幽门螺杆菌毒力基因分型和宿主遗传多态性与胃病关系研究进展[J]. 遗传, 2011, 33(6): 558-566.

ZHANG Li, WANG Peng, WEI Sha-Chi, LIU Chun-Jie. Advances in relationship between gastric disease and polymorphisms in both helicobacter pylori virulence factors and host genetics[J]. HEREDITAS, 2011, 33(6): 558-566.

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幽门螺杆菌毒力基因分型和宿主遗传多态性与胃病关系研究进展

Advances in relationship between gastric disease and polymorphisms in both helicobacter pylori virulence factors and host genetics

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