遗传 ›› 2011, Vol. 33 ›› Issue (6): 558-566.doi: 10.3724/SP.J.1005.2011.00558
张丽1, 2, 王芃1 , 魏莎莉2 , 刘纯杰1
收稿日期:
2010-09-30
修回日期:
2011-01-14
出版日期:
2011-06-20
发布日期:
2011-06-25
通讯作者:
刘纯杰
E-mail:liucj@nic.bmi.ac.cn
基金资助:
“十一五”国家863“疫苗与抗体工程”重大项目基金(编号:2006AA02A219),“十一五”国家“艾滋病和病毒性肝炎等重大传染病防治”重大专项基金(编号:2008ZX10004-015)和“十一五”国家科技支撑计划项目基金(编号:2008BAI66B03)资助
ZHANG Li1,2, WANG Peng1, WEI Sha-Li2, LIU Chun-Jie1
Received:
2010-09-30
Revised:
2011-01-14
Online:
2011-06-20
Published:
2011-06-25
Contact:
LIU Chun-Jie
E-mail:liucj@nic.bmi.ac.cn
摘要: 幽门螺杆菌(Helicobacter pylori)感染能导致慢性胃炎、消化性溃疡、胃粘膜相关的淋巴样组织 (Mu-cosa-associated lymphoid tissue, MALT)淋巴瘤和胃腺癌等疾病的发生。1994年世界卫生组织国际癌症研究中心(IARC)将H.pylori列为胃癌第一级因子。H.pylori感染引起的不同临床结局主要与H.pylori致病因子和宿主遗传易感性有关, 大部分重大疾病发生在特定的细菌毒力因子(如cagA, vacA)与易感宿主遗传背景共同存在时。文章综述了H.pylori菌株的毒力基因的分型和宿主的遗传多态性对胃病发生的影响。
张丽,王芃,魏莎莉,刘纯杰. 幽门螺杆菌毒力基因分型和宿主遗传多态性与胃病关系研究进展[J]. 遗传, 2011, 33(6): 558-566.
ZHANG Li, WANG Peng, WEI Sha-Chi, LIU Chun-Jie. Advances in relationship between gastric disease and polymorphisms in both helicobacter pylori virulence factors and host genetics[J]. HEREDITAS, 2011, 33(6): 558-566.
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