核辅激活因子PGC-1作用分子机制的研究进展

遗传 ›› 2005, Vol. 27 ›› Issue (2): 302-308.

核辅激活因子PGC-1作用分子机制的研究进展

孙亮1~3;金锋2;王沥2;杨泽1

1. 卫生部北京医院卫生部老年医学研究所，北京 100730；2.中国科学院遗传与发育生物学研究所，北京 100101；3. 中国科学院研究生院，北京 100039

收稿日期:2004-09-30 修回日期:2004-12-03 出版日期:2005-04-10 发布日期:2005-04-10
通讯作者: 杨泽

Progress in the Molecular Mechanisms of Nuclear Coactivator PGC-1

SUN Liang1~3;JIN Feng2;WANG Li2;YANG Ze1

1.Institute of Geriatrics, Ministry of Health, Beijing Hospital, Beijing 100730,China;2.Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101,China;3. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China

Received:2004-09-30 Revised:2004-12-03 Online:2005-04-10 Published:2005-04-10
Contact: YANG Ze

摘要/Abstract

摘要： 过氧化物酶体增殖物激活受体γ辅激活因子1（peroxisome proliferator-activated receptor-γ coactivator-1, PGC-1）通过结合下游转录因子广泛参与线粒体生物合成、肝糖异生等重要代谢通路调节，对于维持生物体能量动态平衡有重要生理意义。文章着重综述了基于PGC-1基因及蛋白结构基础的分子对接、组蛋白乙酰化、RNA加工等分子机制的研究现状，并初步探讨了其与代谢综合征发生的应用展望。

关键词: PGC-1, 辅激活因子, p38 MAPK, 转录调节, 组蛋白乙酰化

Abstract: Peroxisome proliferators-activated receptor-γ coactivator-1 is broadly involved in several key cellular pathways including mitochondrial biogenesis, hepatic gluconeogenesis via interacting with many transcription factors, which is highly valuable to maintain the energy balance of organisms. This review especially focuses on the recent progress in the molecular docking, histone acetylation, RNA processing basing on the structure of PGC-1 gene and amino acid sequence. Besides, the prospect of PGC-1 in applications of metabolic syndromes has been discussed also.

Key words: PGC-1, coactivator, transcription regulation, histone acetylation, p38 MAPK

中图分类号:

Q493

孙亮，金锋，王沥，杨泽. 核辅激活因子PGC-1作用分子机制的研究进展[J]. 遗传, 2005, 27(2): 302-308.

SUN Liang~, JIN Feng, WANG Li, YANG Ze. Progress in the Molecular Mechanisms of Nuclear Coactivator PGC-1[J]. HEREDITAS, 2005, 27(2): 302-308.

[1]	鞠君毅,赵权. γ-珠蛋白基因表达调控机制与临床应用[J]. 遗传, 2018, 40(6): 429-444.
[2]	李建辉, 汪春付, 白帆, 庄严, 毛卓君, 孙永涛. 流式细胞术检测组蛋白乙酰化水平方法的建立与应用[J]. 遗传, 2016, 38(6): 581-587.
[3]	乔晓孟,殷芳圆,李云肖,魏曙光,赖江华. 大鼠基底外侧杏仁核组蛋白乙酰化对吗啡成瘾记忆的调控作用[J]. 遗传, 2015, 37(4): 382-387.
[4]	杨峰, 易凡, 曹慧青, 梁子才, 杜权. 长链非编码RNA研究进展[J]. 遗传, 2014, 36(5): 456-468.
[5]	葛少钦，李建忠，张晓静. 精子发生过程中组蛋白甲基化和乙酰化[J]. 遗传, 2011, 33(9): 939-946.
[6]	关秋玲，陈焕新，张毅，李秋莉. 植物GT元件和GT因子的研究进展[J]. 遗传, 2009, 31(2): 123-130.
[7]	张玮玮，黄惠芳，李庆伟，马飞. Y-box结合蛋白功能及对肿瘤发生的影响[J]. 遗传, 2006, 28(9): 1153-1160.
[8]	李想，张飞雄. 关于组蛋白甲基化的研究[J]. 遗传, 2004, 26(2): 244-248.