遗传 ›› 2006, Vol. 28 ›› Issue (6): 641-645.
满晓辉1,徐 岩2,王振宁2,吕 志1,徐米多1,姜 莉1,罗 阳1,徐惠绵2,张 学1,3
MAN Xiao-Hui1;XU Yan2;WANG Zhen-Ning2;FAMZhi1;XU Mi-Duo1;JIANG Li1;LUO Yang1; XU Hui-Mian2,;ZHANG Xue1,3
1. Department of Medical Genomics, MOH Key Laboratory of Cell Biology, China Medical University, Shenyang 110001, China; 2. Department of Surgical Oncology, the First Hospital of China Medical University, Shenyang 110001, China; 3. Department of Medical Genetics, National Key Laboratory of Medical Molecular Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China
摘要: 目的 研究贲门癌中染色体8p21-p23杂合性丢失的情况。方法 采用激光捕获显微切割技术获得均质的肿瘤细胞及正常的胃粘膜细胞,多重置换扩增技术扩增捕获细胞的基因组DNA。PCR结合硝酸银染色方法分析19例贲门癌染色体8p21-p23的杂合性丢失。结果 在贲门癌中染色体8p21-p23的缺失频率非常高(63.2%),我们确定了一个最小丢失区域. 结论 进一步明确此最小丢失区域内的抑癌基因将有助于贲门癌发生机制的阐明。
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