遗传 ›› 2012, Vol. 34 ›› Issue (4): 389-400.doi: 10.3724/SP.J.1005.2012.00389

• 综述 • 上一篇    下一篇

SM蛋白在膜泡运输中的功能

赵翔, 韩宝达, 李立新   

  1. 东北林业大学盐碱地生物资源环境研究中心, 东北油田盐碱植被恢复与重建教育部重点实验室, 哈尔滨150040
  • 收稿日期:2011-10-18 修回日期:2011-11-24 出版日期:2012-04-20 发布日期:2012-04-25
  • 通讯作者: 李立新 E-mail:lixinli1@gmail.com
  • 基金资助:

    国家自然科学基金项目(编号:30840002, 30970223), 黑龙江省留学归国人员科学基金项目(编号:LC08C03), 中央高校基本科研业务费专项资金(编号:DL09DA02) , 东北林业大学引进人才科研启动金(编号:015-602042), 中国博士后科学基金特别资助(编号: 200902365)和黑龙江省留学人员科技活动项目择优资助(编号:2009-HLJLixinLi)

Function of SM protein in vesicle transport

ZHAO Xiang, HAN Bao-Da, LI Li-Xin   

  1. Key Laboratory of Saline-alkali Vegetation Ecology Restoration in Oil Field of Ministry of Education, Alkali Soil Natural Environ-mental Science Center, Northeast Forestry University, Harbin 150040, China
  • Received:2011-10-18 Revised:2011-11-24 Online:2012-04-20 Published:2012-04-25

摘要: 大多数细胞内都包含靶向不同细胞器的各种运输囊泡, 其运输机制在进化上是高度保守的。Sec1/Munc- 18(SM)蛋白在膜泡运输中起着重要的调控作用,它能够与SNARE (Soluble N-ethylmaleimide-sensitive factor attachment protein receptor)蛋白结合, 共同在细胞内各个膜融合发生部位发挥重要作用。SM蛋白和SNARE复合体中的Syntaxin蛋白结合, 调节SNARE复合体的装配, 并与SNARE协同作用促进整个膜融合过程。文章对SM蛋白在结构和功能分析方面的最新研究进展进行了概述。

关键词: 膜泡运输, 膜融合, SNARE蛋白, SM蛋白

Abstract: Most cells contain various transport vesicles that target to different destinations. The underlying molecular mechanisms are highly conserved in evolution. Sec1/Munc-18 (SM) proteins play an important role on regulating vesicle transport by interacting with soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) at each vesicle fusion sites. SM proteins interact with syntaxin, an important component in SNARE complex, to regulate the assembly of SNARE complex, and promote overall membrane fusion process together with SNARE complex. This review summaries new research progresses of structure and function of SM protein.

Key words: vesicle transprot, membrane fusion, SNARE protein, SM protein