犏牛雄性不育的减数分裂基因表达与表观遗传调控研究进展

doi:10.16288/j.yczz.20-176

遗传 ›› 2020, Vol. 42 ›› Issue (11): 1081-1092.doi: 10.16288/j.yczz.20-176

犏牛雄性不育的减数分裂基因表达与表观遗传调控研究进展

陈会友, 张建敏, 李柏森, 邓永琳, 张龚炜()

西南大学动物科学技术学院,重庆 402460

收稿日期:2020-06-15 修回日期:2020-07-14 出版日期:2020-11-20 发布日期:2020-09-23
通讯作者: 张龚炜 E-mail:zgw-vip@163.com
作者简介:陈会友,在读硕士研究生,专业方向：动物遗传育种。E-mail: 17602359737@163.com
基金资助:
国家自然科学基金项目编号(31802046);中央高校基本科研业务费资助编号(XDJK2020D011);中央高校基本科研业务费资助编号(XDJK2019RC001)

Progress on meiotic gene expression and epigenetic regulation of male sterility in Dzo cattle

Huiyou Chen, Jianmin Zhang, Baisen Li, Yonglin Deng, Gongwei Zhang()

College of Animal Science and Technology , Southwest University, Chongqing 402460, China

Received:2020-06-15 Revised:2020-07-14 Online:2020-11-20 Published:2020-09-23
Contact: Zhang Gongwei E-mail:zgw-vip@163.com
Supported by:
Supported by the National Natural Science Foundation of China No(31802046);the Fundamental Research Funds for the Central Universities Nos(XDJK2020D011);the Fundamental Research Funds for the Central Universities Nos(XDJK2019RC001)

摘要/Abstract

摘要：

种间杂交雄性不育是自然界普遍现象,是物种形成生殖隔离的重要方式。犏牛作为牦牛(Bos grunniens)和普通牛(Bos taurus)的种间杂交后代,表现为公犏牛不育,而母犏牛可育,是研究种间杂交雄性不育的良好动物模型。近年来利用分子生物学技术发现犏牛睾丸组织中大量基因表达紊乱。研究表明,DNA甲基化、组蛋白修饰和非编码RNA等表观遗传因素参与精子发生过程。本文从减数分裂相关的基因表达、DNA甲基化、microRNA (miRNA)、PIWI蛋白相互作用的RNA (PIWI-interactingRNA, piRNA)、长链非编码RNA (long non-coding RNA, lncRNA)和组蛋白甲基化修饰等方面总结了犏牛雄性不育的相关研究进展,以期从遗传和表观遗传调控角度更加深入理解犏牛雄性不育的分子机理。

关键词: 犏牛, 雄性不育, 表观遗传, 基因表达

Abstract:

Interspecific hybrid male sterility is a common occurrence in nature and plays an important role in species reproductive isolation. Dzo (cattle-yak), the offspring of interspecific cross between domestic yak (Bos grunniens) and cattle (Bos taurus), is a unique animal model for investigating interspecific hybrid male sterility. Dzo females are completely fertile while the males are sterile. In recent years, molecular studies have demonstrated that the expressions of genes were dysregulated during meiosis in Dzo testis, as compared to those in cattle or yak. Other studies have revealed that epigenetic factors/events, such as DNA methylation, histone modification and non-coding RNA, are also involved in spermatogenesis. This review summarizes the dysregulation of gene expression, DNA methylation, microRNA (miRNA), PIWI-interacting RNA (piRNA), long non-coding RNA (lncRNA), and histone methylation modification during meiosis in Dzo testis. These results highlighted the potential roles of genetic and epigenetic regulations of meiosis in Dzo testis, thereby providing a more detailed understanding on the molecular mechanisms of interspecific hybrid male sterility.

Key words: Dzo, male sterility, epigenetic, gene expression

陈会友, 张建敏, 李柏森, 邓永琳, 张龚炜. 犏牛雄性不育的减数分裂基因表达与表观遗传调控研究进展[J]. 遗传, 2020, 42(11): 1081-1092.

Huiyou Chen, Jianmin Zhang, Baisen Li, Yonglin Deng, Gongwei Zhang. Progress on meiotic gene expression and epigenetic regulation of male sterility in Dzo cattle[J]. Hereditas(Beijing), 2020, 42(11): 1081-1092.

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基因	主要功能	参考文献
DAZ蛋白家族	DAZ、DAZL和BOULE蛋白是精子发生的重要调控因子	[6,26,27]
SYCP蛋白家族	SYCP1、SYCP2、SYCP3和FKBP6是联会复合体的重要组成部分,与精子发生过程中的减数分裂密切相关	[11~13,28,29]
DEAD-box蛋白家族	DDX4、DDX3Y和DDX25是生殖相关基因,参与广泛RNA代谢过程	[15,18,29]
减数分裂同源重组相关基因	DMC1、RAD51、RPA1和BLM是参与哺乳动物减数分裂同源重组修复的关键基因	[20,21]
MSY (Y染色体雄性特异区)相关基因	Y染色体连锁基因家族(TSPY、PRAMEY等)在精子发生和雄性生育中起重要作用	[25,30,31]
SNRPN	SNRPN (small nuclear ribonucleoprotein polypeptide N)与细胞分化和增殖有关	[32,33]
H19、IGF2	印迹基因IGF2 (insulin like growth factor 2)、H19 (H19 imprinted maternally expressed transcript)促进多种细胞的增殖、抑制细胞凋亡	[33,34]
CDC2、CDC25A	CDC2(cell division cycle 2)、CDC25A是减数分裂的两个关键基因	[35]
PIWIL1	PIWIL1(piwi like RNA-mediated gene silencing 1)在精子发生和转座子控制中起重要作用	[29,36]
STRA8	STRA8(stimulated by retinoic acid 8)参与调控精原干细胞(SSCs)自我更新与分化	[37]
PRDM9	PRDM9(PR/SET domain 9)具有PR结构域,和雄性不育相关	[38]
DMRT7	DMRT7(double sex and mab3-relatated transcrip-tion factor7)缺乏是犏牛雄性不育的一个强有力的候选因素	[39]
ERK1、ERK2	ERK1 (extracellular signal-regulated kinase 1)、ERK2属于MAPK信号通路	[40]

犏牛雄性不育的减数分裂基因表达与表观遗传调控研究进展

Progress on meiotic gene expression and epigenetic regulation of male sterility in Dzo cattle

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