环境因素所致印迹基因改变与子代器官发育

doi:10.16288/j.yczz.21-302

遗传 ›› 2022, Vol. 44 ›› Issue (2): 107-116.doi: 10.16288/j.yczz.21-302

环境因素所致印迹基因改变与子代器官发育

曲卉¹(), 柳毅¹, 陈雅文¹, 汪晖^1,²()

1. 武汉大学基础医学院药理学系,武汉 430071
2. 发育源性疾病湖北省重点实验室,武汉 430071

收稿日期:2021-10-01 修回日期:2021-12-21 出版日期:2022-02-20 发布日期:2021-12-22
通讯作者: 汪晖 E-mail:1937211743@qq.com;wanghui19@whu.edu.cn
作者简介:曲卉,在读硕士研究生,专业方向：肾上腺发育毒理。E-mail: 1937211743@qq.com
基金资助:
国家重点研发计划重点专项资助编号(2020YFA0803900)

Alteration of imprinted genes and offspring organ development caused by environmental factors

Hui Qu¹(), Yi Liu¹, Yawen Chen¹, Hui Wang^1,²()

1. Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China
2. Hubei Provincial Key Laboratory of Developmentally Originated Diseases, Wuhan 430071, China

Received:2021-10-01 Revised:2021-12-21 Online:2022-02-20 Published:2021-12-22
Contact: Wang Hui E-mail:1937211743@qq.com;wanghui19@whu.edu.cn
Supported by:
Supported by the Key Project of National Key R&D Program of China No(2020YFA0803900)

摘要/Abstract

摘要：

印迹基因是由大约100个基因组成的一类特殊子集,主要以亲本单等位基因的方式表达,对胚胎的生长发育具有重要作用。近年来发现,环境因素所引起的印迹基因表观遗传修饰改变可造成胎儿多脏器发育不良甚至成年后多疾病易感,且存在多代遗传效应。本文基于国内外最新研究进展,总结了印迹基因表达改变对个体发育阶段以及生命后期器官功能的影响,提出环境有害因素所致印迹基因表观遗传修饰及表达异常是子代多器官发育不良的重要发生机制,这对于理解个体发育过程中印迹基因表达改变所引起的表型改变及探寻疾病早期防治策略具有重要意义。

关键词: 印迹基因, 环境因素, 印迹基因的调控机制, 表观遗传修饰, 器官发育

Abstract:

Imprinted genes are a special subset of about 100 genes, which are mainly expressed in the form of parental monoallelic genes, and play important roles in the growth and development of embryos. In recent years, it has been found that epigenetic modification of imprinted genes induced by environmental factors can cause fetal multi-organ dysplasia and even susceptibility to multiple diseases in adulthood, which also exhibit multi-generational inheritance. In this review, we summarize the effects of expression changes of imprinted genes on ontogenetic development and organ functions in late stage of life, and propose that abnormal epigenetic modification and expression of imprinted genes caused by environmental deleterious factors are important mechanisms for explaining the multi-organ dysplasia in offspring. Such mechanisms are greatly significant for understanding the phenotypic changes caused by alteration of imprinted gene expression during ontogeny and exploring early prevention and treatment strategies of diseases.

Key words: imprinted genes, environmental factors, regulatory mechanisms of imprinted genes, epigenetic modification, organ development

曲卉, 柳毅, 陈雅文, 汪晖. 环境因素所致印迹基因改变与子代器官发育[J]. 遗传, 2022, 44(2): 107-116.

Hui Qu, Yi Liu, Yawen Chen, Hui Wang. Alteration of imprinted genes and offspring organ development caused by environmental factors[J]. Hereditas(Beijing), 2022, 44(2): 107-116.

图/表 3

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环境因素	分类	外源物	印迹基因	影响模式	参考文献
外源性因素	化学因素	酒精	Snrpn	甲基化降低	[28]
	化学因素	TCDD	H19/IGF2	表达下调	[29]
	物理因素	X射线	H19	甲基化模式改变	[30]
	生物因素	直肠弯曲杆菌	IGF2	表达下调	[14]
	ART	体外培养	Peg3	甲基化降低	[31]
	ART	低温保存	IGF2R/Plagl1/ H19	甲基化及表达改变	[32]
亲代因素	疾病状况	母体孕期先兆子痫	Phlda2	表达上调	[33]
	疾病状况	母体产前抑郁症	Peg3	表达下调	[34]
	疾病状况	母体孕期PCOS	H19	表达上调	[35]
	疾病状况	父体肥胖	Mest/Peg3	甲基化降低	[36]
	应激	父体慢性心理应激	Sfmbt2	表达下调	[37]

环境因素所致印迹基因改变与子代器官发育

Alteration of imprinted genes and offspring organ development caused by environmental factors

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[1]	张杨景晖, 常沛瑶, 杨紫淑, 薛宇航, 李雪奇, 张旸. 表观遗传修饰影响花青苷合成研究进展[J]. 遗传, 2022, 44(12): 1117-1127.
[2]	赵清雯, 潘东宁. 表观遗传修饰对脂肪组织产热的调控进展[J]. 遗传, 2022, 44(10): 867-880.
[3]	王雅楠, 徐涛, 王万鹏, 张庆祝, 解莉楠. 表观遗传修饰在作物重要性状形成中的作用[J]. 遗传, 2021, 43(9): 858-879.
[4]	吴杰, 全建平, 叶勇, 吴珍芳, 杨杰, 杨明, 郑恩琴. 染色质转座酶可及性测序研究进展[J]. 遗传, 2020, 42(4): 333-346.
[5]	黎伟, 秦俊, 汪晖, 陈廖斌. 表观遗传生物标志物在人类疾病早期诊治中的研究进展[J]. 遗传, 2018, 40(2): 104-115.
[6]	薛宪词,于黎. 昆虫非遗传多型性研究进展[J]. 遗传, 2017, 39(9): 798-809.
[7]	刘福林, 周瑾, 张蔚, 汪晖. 胎盘发育过程中的表观遗传学改变及其相关疾病[J]. 遗传, 2017, 39(4): 263-275.
[8]	敖政, 刘德武, 蔡更元, 吴珍芳, 李紫聪. 克隆哺乳动物的胎盘发育缺陷[J]. 遗传, 2016, 38(5): 402-410.
[9]	李书粉,李莎,邓传良,卢龙斗,高武军. 转座子在植物XY性染色体起源与演化过程中的作用[J]. 遗传, 2015, 37(2): 157-164.
[10]	陈利, 丁芳, 刘勇, 吴风瑞, 丁彪, 王荣, 李文雍. 小鼠孤雌胚、体外培养胚与体内胚H3K9乙酰式的比较[J]. 遗传, 2015, 37(1): 77-83.
[11]	葛少钦, 赵峥辉, 张雪倩, 郝媛. 精子表观遗传修饰及其在胚胎发育过程中的潜在作用[J]. 遗传, 2014, 36(5): 439-446.
[12]	曹家雪张红平杜立新. 环境因素对DNA甲基化的影响[J]. 遗传, 2013, 35(7): 839-846.
[13]	潘丽娜. 表观遗传修饰调控非生物胁迫应答提高植物抗逆性的研究进展[J]. 遗传, 2013, 35(6): 745-751.
[14]	王学耕朱作言孙永华赵珏. 鱼类核移植与重编程[J]. 遗传, 2013, 35(4): 433-440.
[15]	汤琳琳刘琼步世忠徐雷艇王钦文麦一峰段世伟. 2型糖尿病环境因素与DNA甲基化的研究进展[J]. 遗传, 2013, 35(10): 1143-1152.