遗传 ›› 2021, Vol. 43 ›› Issue (11): 1038-1049.doi: 10.16288/j.yczz.21-206

• 综述 • 上一篇    下一篇

哺乳动物纤毛/鞭毛内运输在精子形成中的作用及机制研究进展

葛婷婷(), 袁露, 徐文华, 郑英()   

  1. 扬州大学医学院组织学与胚胎学教研室,江苏省非编码RNA基础与临床转化重点实验室,扬州 225009
  • 收稿日期:2021-06-10 修回日期:2021-08-29 出版日期:2021-11-20 发布日期:2021-10-14
  • 通讯作者: 郑英 E-mail:1499356709@qq.com;yzzkl@163.com
  • 作者简介:葛婷婷,在读硕士研究生,专业方向:生殖医学。E-mail: 1499356709@qq.com
  • 基金资助:
    国家自然科学基金项目编号(82071696);江苏省高校自然科学研究重大项目编号(20KJA310002);扬州大学研究生科研创新计划项目编号资助(XKYCX20_35)

Role and mechanism of intraflagellar transport in mammalian spermiogenesis

Ge Tingting(), Yuan Lu, Xu Wenhua, Zheng Ying()   

  1. Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, Department of Histology and Embryology, School of Medicine, Yangzhou University, Yangzhou 225009, China
  • Received:2021-06-10 Revised:2021-08-29 Online:2021-11-20 Published:2021-10-14
  • Contact: Zheng Ying E-mail:1499356709@qq.com;yzzkl@163.com
  • Supported by:
    Supported by the National Natural Science Foundation of China No(82071696);Natural Science Foundation of Jiangsu Province No(20KJA310002);the Postgraduate Scientific Research Innovation Program of Yangzhou University No(XKYCX20_35)

摘要:

纤毛/鞭毛是真核生物细胞表面伸出的进化保守的细胞器,独特的位置和特性使它们在细胞运动和信号传递等生命过程发挥重要作用。哺乳动物纤毛/鞭毛的组装和维持都依赖纤毛/鞭毛内运输(intraflagellar transport, IFT)。IFT是由IFT复合体A和复合体B在驱动蛋白或马达蛋白驱动下的双向运输系统。该过程可将货物蛋白在胞体的合成位点与纤毛/鞭毛尖端的装配位点之间进行运输。鞭毛是哺乳动物精子产生动力的特异性细胞器,其完整性对精子正常功能至关重要。近年来研究表明,IFT在哺乳动物精子鞭毛形成和雄性生殖能力方面必不可少。本文对参与IFT的蛋白在精子鞭毛形成中的作用和机制进行了综述,以探讨其在男性不育症中的发病机制,为不育症的诊断和治疗提供理论基础。

关键词: 纤毛/鞭毛内运输, 精子形成, 雄性不育

Abstract:

Eukaryotic cilia and flagella are evolutionarily conserved organelles that protrude from the cell surface. The unique location and properties of cilia allow them to function in vital processes such as motility and signaling. Ciliary assembly and maintenance rely on intraflagellar transport (IFT). Bidirectional movement of IFT particles composed of IFT-A and IFT-B complexes is powered by kinesin-2 and dynein-2 motors. IFT delivers building blocks between their site of synthesis in the cell body and the ciliary assembly site at the tip of the cilium. The integrity of the flagellum, a specialized organelle of mammalian sperm to generate the motility, is critical for normal sperm function. Recent findings suggest that IFT is indispensable for sperm flagellum formation and male fertility in mice and human. In this review, we summarize the role and mechanisms of IFT proteins during enflagellation in spermiogenesis, thereby discussing the pathological mechanisms of male infertility and providing theoretical basis for the diagnosis and treatment of male infertility.

Key words: intraflagellar transport, spermiogenesis, male infertility