遗传 ›› 2004, Vol. 26 ›› Issue (4): 560-566.

• 论文 • 上一篇    下一篇

苔藓植物小立碗藓,功能基因组学研究新的模式系统

董 文; 李 卫; 郭光沁; 郑国锠DONG Wen; LI Wei; GUO Guang-Qin; ZHENG Guo-Chang   

  1. 兰州大学细胞研究所,兰州 730000Institute of Cell Biology, Lanzhou University, Lanzhou 730000, China
  • 收稿日期:1900-01-01 出版日期:2004-08-10 发布日期:2004-08-10

The Moss Physcomitrella patens, a New Model System for Functional Genomics

  • Received:1900-01-01 Online:2004-08-10 Published:2004-08-10

摘要:


苔藓植物具有相对简单的发育模式,单倍体的配子体在其生活史中占主导地位,作为研究植物生物学过程的模式系统具有诸多的优越性。苔藓植物小立碗藓能够高效地通过同源重组的方式将外源核酸整合到其核DNA,这就使得基因打靶在此物种中就像在小鼠胚胎干细胞和酵母中一样成为一个非常便利的技术。另外由于小立碗藓与高等植物在生物特征上有很大相似之处加之其有其他诸多优越性,它有望成为一个诱人的植物生物学和功能基因组学研究的模式系统。Abstract:The potential of moss as a model system to study plant biological process is associated with their relatively simple developmental pattern and the dominance of the haploid gametophyte in the life cycle. The moss Physcomitrella patens exhibits a very high rate of homologous recombination in its nuclear DNA, making gene targeting approaches in this plant as convenient as in yeast or in ES cells of mice. Sharing many biological features with higher plants and having many other advantages, the moss Physcomitrella patens will be an attractive model system for plant biology and functional genome analysis.

关键词: 苔藓植物, 模式系统, 基因打靶, 反求遗传学, 功能基因组学