遗传 ›› 2002, Vol. 24 ›› Issue (1): 6-8.

• 论文 • 上一篇    下一篇

飞行员中血管紧张素转换酶基因插入或缺失多态性研究

蔡庆;刘红巾;朱美财;姜树强;王荫静;占志;姜建东 CAI Qing;LIU Hong-jin;ZHU Mei-cai;JIANG Shu-qiang;WANG Yin-jing;ZHAN Zhi;JIANG Jian-dong   

  1. 空军总医院分子生物学研究中心,北京 100036 Department of Molecular Biology,General Hospital of Air Force,Beijing 100036,China
  • 收稿日期:1900-01-01 出版日期:2002-02-10 发布日期:2002-02-10

A Study of Insertion/Delation Polymorphism of the Angiotensin-Converting Enzyme Gene in Pilots

  • Received:1900-01-01 Online:2002-02-10 Published:2002-02-10

摘要: 为了解飞行员血管紧张素转换酶(ACE)基因插入或缺失(I/D)多态性情况,探讨ACE基因多态性与飞行员耐力可能的关系,用聚合酶链反应(PCR)扩增技术检测118例飞行员和96例健康对照者的ACE基因I/D多态性。 结果位于ACE基因内含子16的I/D多态性经PCR扩增后呈三种基因型:纯合子插入型(II)、纯合子缺失型(DD)和杂合子插入或缺失型(I/D)。飞行员组II基因型(44.07%)和I等位基因频率(0.65)显著高于健康对照组(分别为31.25%和0.52)。 结果表明ACE I基因有可能在飞行员的飞行耐力中起重要作用。
Abstract:In order to understand insertion/delation (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in pilots,and to explore the relationship between ACE gene I/D polymorphism and the perfomance of the pilots,the polymerase chain reaction (PCR) was used to determine the genotypes for an I/D polymorphism in intron 16 of the ACE gene in 118 pilots and 96 healthy subjects as controls.The result showed that the I/D polymorphism in intron 16 of the ACE gene was categorized into three genotypes: two deletion alleles (genotype DD),heterozygous alleles (genotype ID),and two insertion alleles (genotype II).The genotype II and I allele frequency were significantly higher in pilots (44.07% and 0.65) than that in healthy subjects (31.25% and 0.52).It is suggested that I gene of ACE may play a role in perfomance of the pilots.

关键词: angiotensin-converting enzyme, 飞行员
Key words,
血管紧张素转换酶, 基因多态性, gene polymorphism