摘要: ADAM,又称MDC,分别是去整合蛋白和金属蛋白水解酶(a disintegrin and metalloproteinase,ADAM)及金属蛋白水解酶、去整合蛋白和富半胱氨酸(metalloproteinase/disintegrin/cysteine-rich,MDC)的英文缩写,是近几年在多细胞动物中发现的一类含信号肽区、前调控区、金属蛋白水解酶区、去整合蛋白区、富半胱氨酸区、上皮生长因子区、跨膜区和胞内区的细胞表面糖蛋白,本文简要总结了有关ADAM起源、遗传、进化和亲缘关系的研究结果。
Abstract:ADAM (a disintegrin and metalloproteinase),or named MDC (metalloproteinase/disintegrin/cysteine-rich) is a family of glycoproteins in cell surface,which was found in recent years and consists of a signal peptide,a propetide,a metalloproteinase,a disintegrin,a cysteine-rich domain,and an epidermal growth factor (EGF)-like domain,a transmembrane region,and a cytoplasmic tail.The research results about their origin,heredity,evolution and evolutionary relationship are summaried in this paper.