TBC蛋白家族成员在人类疾病发生发展中的作用

doi:10.16288/j.yczz.17-343

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Hereditas(Beijing) ›› 2018, Vol. 40 ›› Issue (1): 12-21.doi: 10.16288/j.yczz.17-343

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The critical roles of TBC proteins in human diseases

Mengting Shi^1,²(),Ying Zhang²,Gangqiao Zhou^{^1,²}()

1. Graduate School, Guangxi Medical University, Nanning 530021, China
2. National Center for Protein Sciences, the State Key Lab of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China

Received:2017-10-22 Revised:2017-12-12 Online:2018-01-20 Published:2017-12-22
Supported by:
the National Science Foundation of China(81401981)

Abstract

Abstract:

The Tre-2/Bub2/Cdc16 (TBC) domain is a conserved protein motif consisting of approximately 200 amino acids, and is present in many eukaryotic proteins. TBC domain-containing proteins (TBC proteins) function as GTPase activating proteins (GAPs) for the small GTPase Rab, which can promote the hydrolysis of Rab-GTP to Rab-GDP in regulation of specific intracellular trafficking pathways. Several TBC proteins play important roles in cellular functions in mammals, and defects of which are closely associated with numerous disease processes. In this review, we summarize the structures and functions of the mammalian TBC proteins and recent advances in understanding their critical roles in the development of human diseases. This review serves as a reference for further investigations on the functions of TBC proteins in disease pathogeneses.

Key words: Rab, TBC, GTPase activating protein, trafficking

Mengting Shi, Ying Zhang, Gangqiao Zhou. The critical roles of TBC proteins in human diseases[J]. Hereditas(Beijing), 2018, 40(1): 12-21.

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