从遗传力到肠菌力：概念及研究进展

doi:10.16288/j.yczz.19-130

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Hereditas(Beijing) ›› 2019, Vol. 41 ›› Issue (11): 1023-1040.doi: 10.16288/j.yczz.19-130

• Review • Previous Articles Next Articles

The concepts and research progress: from heritability to microbiability

Chaoliang Wen,Congjiao Sun,Ning Yang()

National Engineering Laboratory for Animal Breeding, College of Animal Science andTechnology, China Agricultural University, Beijing100193, China

Received:2019-05-13 Revised:2019-09-23 Online:2019-11-20 Published:2019-11-08
Contact: Yang Ning E-mail:nyang@cau.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China No.(31930105);China Agriculture Research Systems No.(CARS-40);Programs for Changjiang Scholars and Innovative Research in Universities No.(IRT_15R62)

Abstract

Abstract:

Heritability, one of the central quantitative genetic parameters, is critically important to measure the genetic variation of traits, especially in the studies of the response to selection in evolutionary biology and agriculture, and the prediction of disease risks in medicine. The statistical model and method for estimating heritability have been continually developed and improved, since the genetic variance components was first proposed by Fisher in 1918. Recently, the term “microbiability” (m ²), an analogous concept and estimated method to heritability, was introduced in gut microbiome research for evaluating the effect of entire microbiota on a host phenotype. In this review, we summarize the progress of statistical methods in the heritability estimation, as well as the current state of gut microbiome associations with the host genome, with a particular focus on the concept and estimated methods of microbiability. Our review will provide a reference for the future study of host phenotypic variation that can be inferred by the gut microbiota.

Key words: heritability, microbiability, association study, quantitative trait, variance component, relationship matrix

Chaoliang Wen, Congjiao Sun, Ning Yang. The concepts and research progress: from heritability to microbiability[J]. Hereditas(Beijing), 2019, 41(11): 1023-1040.

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