组蛋白变体H2A.Z的转录调控功能与动态作用机制

doi:10.16288/j.yczz.23-307

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Hereditas(Beijing) ›› 2024, Vol. 46 ›› Issue (4): 279-289.doi: 10.16288/j.yczz.23-307

• Review • Previous Articles Next Articles

The roles and mechanisms of histone variant H2A.Z in transcriptional regulation

Zhaoran Sun(), Xudong Wu()

School of Basic Medical Sciences, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China

Received:2023-12-13 Revised:2024-02-27 Online:2024-04-20 Published:2024-02-29
Contact: Xudong Wu E-mail:591162534@qq.com;wuxudong@tmu.edu.cn
Supported by:
National Natural Science Foundation of China(31870725);National Natural Science Foundation of China(32071204)

Abstract

Abstract:

H2A.Z, one of the most well-known variants of histone H2A, has been extensively investigated on its dual roles in gene transcription in recent years. In this review, we focus on the intricate involvement of H2A.Z in transcriptional regulation, including the assembly of distinct H2A.Z subtypes, post-translational modifications and genomic distributions. Emphasis is placed on the biological and pathophysiological implications, particularly in tumorigenesis and nervous system development. We summarize the dynamic regulatory mechanisms governing H2A.Z deposition or eviction on chromatin to provide insights for understanding the diversity of histone variants and promoting the search of new targets in concerned disease diagnosis and treatment.

Key words: epigenetic regulation, nucleosome, gene transcription, histone variant, H2A.Z

Zhaoran Sun, Xudong Wu. The roles and mechanisms of histone variant H2A.Z in transcriptional regulation[J]. Hereditas(Beijing), 2024, 46(4): 279-289.

Figures/Tables 2

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The roles and mechanisms of histone variant H2A.Z in transcriptional regulation

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