人肠道病毒71型与手足口病的分子流行病学及其分子进化

doi:10.16288/j.yczz.14-255

遗传 ›› 2015, Vol. 37 ›› Issue (5): 426-435.doi: 10.16288/j.yczz.14-255

人肠道病毒71型与手足口病的分子流行病学及其分子进化

刘志芳,桂娟娟,华启航,董长征

宁波大学医学院预防医学系,宁波 315211

收稿日期:2014-07-30 出版日期:2015-05-20 发布日期:2015-05-20
通讯作者: 华启航,讲师,研究方向：生物信息学和统计遗传学。E-mail: huaqihang@nbu.edu.cn;董长征,博士,副教授,研究方向：生物信息学和统计遗传学。E-mail: dongchangzheng@nbu.edu.cn
作者简介:刘志芳,在读硕士研究生,专业方向：生物信息学和统计遗传学。E-mail: 812314988@qq.com; 桂娟娟,在读硕士研究生,专业方向：生物信息学和统计遗传学。E-mail: 852042146@qq.com;刘志芳和桂娟娟并列第一作者。
基金资助:
国家自然科学基金项目(编号：31000594)和宁波大学学科项目(编号：XKL141060)资助

Molecular epidemiology and evolution of human enterovirus 71 and hand, foot and mouth disease

Zhifang Liu, Juanjuan Gui, Qihang Hua, Changzheng Dong

Department of Preventive Medicine, School of Medicine, Ningbo University, Ningbo 315211, China

Received:2014-07-30 Online:2015-05-20 Published:2015-05-20

摘要/Abstract

摘要： 人肠道病毒71血清型(Enterovirus 71, EV71)是手足口病(Hand, foot and mouth disease, HFMD)的主要病原体之一,除了引起手、足和口腔等部位出现疱疹的手足口病典型症状,还能引起无菌性脑膜炎和急性迟缓性麻痹等神经系统并发症并致死亡。EV71在历史上曾经造成多起手足口病疫情,尤其是1997年之后,在亚太地区发生了大规模的手足口病疫情,造成了大量的手足口病病例和死亡病例。手足口病尚无上市疫苗和抗病毒药物,主要依赖对症治疗,因此对EV71的分子流行病学和分子进化研究对手足口病的监测和防控具有重要意义。文章对EV71基因型的分类、时空分布、进化特征和模式以及所造成的代表性疫情进行了综述,为EV71致病机制、抗病毒药物和疫苗的研究以及对手足口病疫情的监测和防控提供启发。

关键词: 手足口病, 肠道病毒71型, 基因型, 疫情, 时空分布

Abstract: Human enterovirus 71(EV71), one of the major pathogens of the hand, foot and mouth disease (HFMD),

刘志芳,桂娟娟,华启航,董长征. 人肠道病毒71型与手足口病的分子流行病学及其分子进化[J]. 遗传, 2015, 37(5): 426-435.

Zhifang Liu, Juanjuan Gui, Qihang Hua, Changzheng Dong. Molecular epidemiology and evolution of human enterovirus 71 and hand, foot and mouth disease[J]. HEREDITAS(Beijing), 2015, 37(5): 426-435.

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人肠道病毒71型与手足口病的分子流行病学及其分子进化

Molecular epidemiology and evolution of human enterovirus 71 and hand, foot and mouth disease

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