HCV基因型的差异性流行与进化

doi:10.3724/SP.J.1005.2012.00666

遗传 ›› 2012, Vol. 34 ›› Issue (6): 666-672.doi: 10.3724/SP.J.1005.2012.00666

HCV基因型的差异性流行与进化

赵璐, 冯悦, 夏雪山

昆明理工大学生命科学与技术学院, 昆明 650500

收稿日期:2011-11-11 修回日期:2012-02-15 出版日期:2012-06-20 发布日期:2012-06-25
通讯作者: 夏雪山 E-mail:oliverxia2000@yahoo.com.cn

The different epidemic and evolution of HCV genotypes

ZHAO Lu, FENG Yue, XIA Xue-Shan

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China

Received:2011-11-11 Revised:2012-02-15 Online:2012-06-20 Published:2012-06-25

摘要/Abstract

摘要： 丙型肝炎病毒(Hepatitis C virus , HCV)是导致慢性肝炎的主要病原体之一, 全球感染人数大约为1.7亿。HCV基因组具有高度变异特性, 利用现代遗传分类方法, 可将HCV分为6个基因型和80多个基因亚型。不同HCV基因型、亚型的分布与流行具有明显地域特性：1型、2型呈全球流行态势, 3型主要流行于亚洲、北美及欧洲部分地区, 4型主要流行于中非、中东和欧洲地区, 5型主要发现于非洲和欧洲部分国家, 6型则主要在东南亚和北美地区流行。我国流行的HCV有1、2、3和6四种基因型, 北方仍以1b和2a型为主要流行基因型, 近年来3型和6型在华南、西南地区快速传播。据推断, 云南将可能成为我国HCV流行与传播的重要源头, 引起目前HCV基因型/亚型分布的较大变化, 并呈现多样化的传播方式。通过溯祖理论和进化分子钟等分析方法, 了解HCV不同基因型差异性流行与进化, 对研究HCV的分子流行病学特征, 对应性制定丙型肝炎的预防控制策略具有重要意义。

关键词: HCV, 流行, 分子钟, 进化, 基因型

Abstract: Hepatitis C virus (HCV) is a prevalent and globally distributed human pathogen that currently infects an estimated 170 million people. Chronic HCV infection significantly increases the risk of chronic hepatitis. The virus exhibits a very high degree of genetic diversity that is classified six genotypes and sub-classified more than 80 subtypes by phylogenetic analysis. The various genotypes and subtypes of HCV have been associated with different epidemiological and geographical spread patterns. Genotypes 1 and 2 are globally distributed; genotype 3 is predominant in Asia, North America and parts of Europe; similar regional patterns of endemic diversity have been found for genotype 4 in Europe, Middle East and Central Africa, for genotype 5 in parts of Africa and Europe, and for genotype 6 in Southeast Asia and North America. Up to date, four HCV genotypes, including genotype 1, 2, 3 and 6, were identified in China. Genotypes 1b and 2a were mainly found in Northern China. The fast spreading of genotypes 3 and 6 in Southern and South-Western China was reported by recent studies. It’s deduced that Yunnan may become an important source of HCV epidemic and spread, which will cause great changes in the distribution of HCV genotypes and subtypes, and a variety of transmission. With the development of evolution theory and related analysis methods, such as coalescent theory and evolutionary molecular, it is possible to understand the characters of virus evolution and migration. For HCV, the further understanding on the prevalence and evolution characters of various genotypes is very important for the deep investigation of HCV epidemic and the develop-ment of prevention strategy.

Key words: HCV, prevalence, molecular clock, evolution, genotype

赵璐，冯悦，夏雪山. HCV基因型的差异性流行与进化[J]. 遗传, 2012, 34(6): 666-672.

ZHAO Lu, FENG Yue, XIA Xue-Shan. The different epidemic and evolution of HCV genotypes[J]. HEREDITAS, 2012, 34(6): 666-672.

参考文献

[1] Centers for Disease Control and Prevention(CDC). Recommendations for prevention and control of hepatitis C virus (HCV) infection and HCV related chronic disease. MMWR Recomm Rep, 1998, 47(RR19): 1-39.
[2] Lauer GM, Walker BD. Hepatitis C virus infection. N Engl J Med, 2001, 345(1): 41-52.
[3] Williams R. Global challenges in liver disease. Hepatology, 2006, 44(3): 521-526.
[4] Chen YD, Liu MY, Yu WL, Li JQ, Peng M, Dai Q, Liu X, Zhou ZQ. Hepatitis C virus infections and genotypes in China. Hepatobiliary Pancreat Dis Int, 2002, 1(2): 194-201.
[5] Xia X, Luo J, Bai JL, Yu RB. Epidemiology of hepatitis C virus infection among injection drug users in China: systematic review and meta-analysis. Public Health, 2008, 122(10): 990-1003.
[6] Tsukiyama-Kohara K, Iizuka N, Kohara M, Nomoto A. Internal ribosome entry site within hepatitis C virus RNA. J Virol, 1992, 66(3): 1476-1483.
[7] Neumann AU, Lam NP, Dahari H, Gretch DR, Wiley TE, Layden TJ, Perelson AS. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-α therapy. Science, 1998, 282(5386): 103-107.
[8] Kang SM, Choi SH, Park CY, Kim MH, Kim TK, Park JM, Koh MS, Kang HJ, Hwang SB. Monoclonal antibody recognizing N-terminal epitope of hepatitis C virus nonstructural 5B inhibits viral RNA replication. J Viral Hepat, 2008, 15(4): 305-313.
[9] 张中林, 山松, 陈曦, 苏宁, 吴祥甫, 钱凯先, 沈桂芳. 丙肝病毒融合抗原基因NS3-C定点整合入衣藻叶绿体基因组的研究. 遗传, 1999, 21(6): 1-173.
[10] Simmonds P, Holmes EC, Cha TA, Chan SW, McOmish F, Irvine B, Beall E, Yap PL, Kolberg J, Urdea MS. Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. J Gen Virol, 1993, 74(Pt11): 2391-2399.
[11] Murphy DG, Willems B, Deschênes M, Hilzenrat N, Mousseau R, Sabbah S. Use of sequence analysis of the NS5B region for routine genotyping of hepatitis C virus with reference to C/E1 and 5′ untranslated region sequences. J Clin Microbiol, 2007, 45(4): 1102-1112.
[12] Simmonds P. Genetic diversity and evolution of hepatitis C virus 15-years on. J Gen Virol, 2004, 85(Pt11): 3173-3188.
[13] Major ME, Feinstone SM. The molecular virology of hepatitis C. Hepatology, 1997, 25(6): 1527-1538.
[14] Pybus OG, Markov PV, Wu A, Tatem AJ. Investigating the endemic transmission of the hepatitis C virus. Int J Parasitol, 2007, 37(8-9): 839-849.
[15] Kuiken C, Yusim K, Boykin L, Richardson R. The Los Alamos hepatitis C sequence database. Bioinformatics, 21(3): 379-384.
[16] Kryczka W, Brojer E, Zarebska-Michaluk D, Medyńska J, Urbaniak A. Factors influencing natural history of chronic hepatitis C. Med Sci Monit, 2001, (Suppl. 1): 212-216.
[17] Nakano I, Fukuda Y, Katano Y, Toyoda H, Hayashi K, Hayakawa T, Kumada T, Nakano S. Interferon responsiveness in patients infected with hepatitis C virus 1b differs depending on viral subtype. Gut, 2001, 49(2): 263-267.
[18] Nakano T, Lu L, Liu P, Pybus OG. Viral gene sequences reveal the variable history of hepatitis C virus infection among countries. J Infect Dis, 2004, 190(6): 1098-1108.
[19] Drummond AJ, Rambaut A. BEAST: Bayesian evolutionary analysis by sampling trees. BMC Evol Biol, 2007, 7: 214.
[20] 敖雁, 朱明星, 徐辰武. 贝叶斯统计在QTL作图中的应用研究进展. 遗传, 2007, 29(6): 668-674.
[21] Magiorkinis G, Magiorkinis E, Paraskevis D, Ho SY, Shapiro B, Pybus OG, Allain JP, Hatzakis A. The global spread of hepatitis C virus 1a and 1b: A phylodynamic and phylogeographic analysis. PLoS Med, 2009, 6(12): e1000198.
[22] Courtwright D. Dark paradise: a history of opiate addiction in America. Cambridge: Harvard University Press, 2001.
[23] Stimson GV. The global diffusion of injecting drug use: implications for human immunodeficiency virus infection. Bull Narc, 1993, 45(1): 3-17.
[24] Markov PV, Pepin J, Frost E, Deslandes S, Labbé AC, Pybus OG. Phylogeography and molecular epidemiology of hepatitis C virus genotype 2 in Africa. J Gen Vi-rol, 2009, 90(Pt9): 2086-2096.
[25] Khan A, Tanaka Y, Azam Z, Abbas Z, Kurbanov F, Saleem U, Hamid S, Jafri W, Mizokami M. Epidemic spread of hepatitis C virus genotype 3a and relation to high incidence of hepatocellular carcinoma in Pakistan. J Med Virol, 2009, 81(7): 1189-1197.
[26] Verma V, Chakravarti A, Kar P. Genotypic characterization of hepatitis C virus and its significance in patients with chronic liver disease from Northern India. Diagn Microbiol Infect Dis, 2008, 61(4): 408-414.
[27] EMRO. Health System Organization-Health System ProfilePakistan. Regional Health Systems Observatory-World Health Organization, 2007: 28-42.
[28] Pybus OG, Cochrane A, Holmes EC, Simmonds P. The hepatitis C virus epidemic among injecting drug users. Infect Genet Evol, 2005, 5(2): 131-139.
[29] Esteban JI, Sauleda S, Quer J. The changing epidemiology of hepatitis C virus infection in Europe. J Hepatol, 2008, 48(1): 148-162.
[30] Njouom R, Frost E, Deslandes S, Mamadou-Yaya F, Labbé AC, Pouillot R, Mbélesso P, Mbadingai S, Rousset D, Pépin J. Predominance of hepatitis C virus genotype 4 infection and rapid transmission between 1935 and 1965 in the Central African Republic. J Gen Virol, 2009, 90(Pt 10): 2452-2456.
[31] Abdel-Hamid M, El-Daly M, Molnegren V, El-Kafrawy S, Abdel-Latif S, Esmat G, Strickland GT, Loffredo C, Albert J, Widell A. Genetic diversity in hepatitis C virus in Egypt and possible association with hepatocellular carcinoma. J Gen Virol, 2007, 88(Pt 5): 1526-1531.
[32] Pybus OG, Drummond AJ, Nakano T, Robertson BH, Rambaut A. The epidemiology and iatrogenic transmission of hepatitis C virus in Egypt: A Bayesian coalescent approach. Mol Biol Evol, 2003, 20(3): 381-387.
[33] Tanaka Y, Agha S, Saudy N, Kurbanov F, Orito E, Kato T, Abo-Zeid M, Khalaf M, Miyakawa Y, Mizokami M. Exponential spread of hepatitis C virus genotype 4a in Egypt. J Mol Evol, 2004, 58(2): 191-195.
[34] Verbeeck J, Maes P, Lemey P, Pybus OG, Wollants E, Song E, Nevens F, Fevery J, Delport W, Van der Merwe S, Van Ranst M. Investigating the origin and spread of hepatitis C virus genotype 5a. J Virol, 2006, 80(9): 4220-4226.
[35] Henquell C, Guglielmini J, Verbeeck J, Mahul A, Thibault V, Lebray P, Laperche S, Trimoulet P, Foucher J, Le Guillou-Guillemette H, Fouchard-Hubert I, Legrand- Abravanel F, Métivier S, Gaudy C, D'Alteroche L, Rosenberg AR, Podevin P, Plantier JC, Riachi G, Saoudin H, Coppere H, André E, Gournay J, Feray C, Vallet S, Nousbaum JB, Baazia Y, Roulot D, Alain S, Loustaud- Ratti V, Schvoerer E, Habersetzer F, Pérez-Serra RJ, Gourari S, Mirand A, Odent-Malaure H, Garraud O, Izopet J, Bommelaer G, Peigue-Lafeuille H, van Ranst M, Abergel A, Bailly JL. Evolutionary history of hepatitis C virus genotype 5a in France, a multicenter ANRS study. Infection, Genetics and Evolution, 2011, 11(2): 496-503.
[36] World Health Organization. Hepatitis C-global prevalence. Wkly Epidemiol Rec, 1997, 14(46): 341-344.
[37] Hauri AM, Armstrong GL, Hutin YJ. The global burden of disease attributable to contaminated injections given in health care settings. Int J STD AIDS, 2004, 15(1): 7-16.
[38] Stumpf MPH, Pybus OG. Genetic diversity and models of viral evolution for the hepatitis C virus. FEMS Microbiol Lett, 2002, 214(2): 143-152.
[39] Xia XS, Lu L, Tee KK, Zhao WH, Wu JG, Yu J, Li XJ, Lin YX, Mukhtar MM, Hagedorn CH, Takebe Y. The unique HCV genotype distribution and the discovery of a novel subtype 6u among IDUs co-infected with HIV-1 in Yunnan, China. J Med Virol, 2008, 80(7): 1142-1152.
[40] Nakano T, Lu L, He YS, Fu YS, Robertson BH, Pybus OG. Population genetic history of hepatitis C virus 1b infection in China. J Gen Virol, 2006, 87(1): 73-82.
[41] Fu Y, Wang Y, Xia W, Pybus OG, Qin W, Lu L, Nelson K. New trends of HCV infection in China revealed by genetic analysis of viral sequences determined from first-time volunteer blood donors. J Viral Hepat, 2011, 18(1): 42-52.
[42] 桂亚萍, 郑惠, 沃垮, 孔令和. 九江地区丙型肝炎病毒基因分型. 实验与检验医学, 2010, 28(5): 514-515.
[43] 刘剑荣, 黄永建, 夏洪娇, 张勇. 丙型肝炎基因型分布特点及流行分析. 国际检验医学杂志, 2010, 31(12): 1847-1848.
[44] Zhang CY, Wu NN, Liu J, Ge QJ, Huang Y, Ren Q, Feng QC, He GL. HCV subtype characterization among injection drug users: implication for a crucial role of Zhenjiang in HCV transmission in China. PLoS One, 2011, 6(2): e16817.
[45] Fu YS, Qin WB, Cao H, Xu R, Tan Y, Lu T, Wang HR, Tong WX, Rong X, Li G, Yuan MQ, Li CH, Abe K, Lu L, Chen GH. HCV 6a prevalence in guangdong province had the origin from Vietnam and recent dissemination to other regions of china: phylogeographic analyses. PLoS One, 2012, 7(1): e28006.
[46] 洪国祜, 谭朝霞, 郭艳, 毛青. 中国西南地区丙型肝炎病毒6a亚型病毒株的传播速率. 中华肝脏病杂志, 2011, 19(7): 502-505.
[47] Hesketh T, Wei XZ. Health in China From Mao to market reform. BMJ, 1997, 314(7093): 1543-1545.
[48] Zhang C, Yang R, Xia X, Qin S, Dai J, Zhang Z, Peng Z, Wei T, Liu H, Pu D, Luo J, Takebe Y, Ben K. High prevalence of HIV-1 and hepatitis C virus coinfection among injection drug users in the southeastern region of Yunnan, China. J Acquir Immune Defic Syndr, 2002, 29(2): 191-196.
[49] Wang YZ, Xia XS, Li CH, Maneekarn N, Xia WJ, Zhao WH, Feng Y, Kung HF, Fu YS, Lu L. A new HCV genotype 6 subtype designated 6v was confirmed with three complete genome sequences. J Clin Virol, 2009, 44(3): 195-199.
[50] Xia XS, Zhao WH, Tee KK, Feng Y, Takebe Y, Li QH, Pybus OG, Lu L. Complete genome sequencing and phylogenetic analysis of HCV isolates from China reveals a new subtype, designated 6u. J Med Virol, 2008, 80(10): 1740-1746.
[51] Lu L, Nakano T, He YS, Fu YS, Hagedorn CH, Robertson BH. Hepatitis C virus genotype distribution in China: predominance of closely related subtype 1b isolates and existence of new genotype 6 variants. J Med Virol, 2005, 75(4): 538-549.
[52] Zhou YQ, Wang XH, Mao Q, Fan Y, Zhu Y, Zhang XQ, Lan L, Jiang L, Tan WT. Changes in modes of hepatitis C infection acquisition and genotypes in southwest China. J Clin Virol, 2009, 46(3): 230-233.
[53] Liu PP, Xiang KL, Tang H, Zhang W, Wang XQ, Tong X, Takebe Y, Yang RG. Molecular epidemiology of human immunodeficiency virus type 1 and hepatitis C virus in former blood donors in central China. AIDS Res Hum Retroviruses, 2008, 24(1): 1-6.
[54] World Health Organization. http://www.who.int/en/. 2011.
[55] Tee KK, Pybus OG, Li XJ, Han X, Shang H, Kamarulzaman A, Takebe Y. Temporal and spatial dynamics of human immunodeficiency virus type 1 circulating recombinant forms 08_BC and 07_BC in Asia. J Virol, 2008, 82(18): 9206-9215.

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

HCV基因型的差异性流行与进化

The different epidemic and evolution of HCV genotypes

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	李智,何俊,蒋隽,Richard G. Tait Jr.,Stewart Bauck,过伟,吴晓林. 牛SNP芯片分型检出率和分型错误率对基因型填充准确率的影响[J]. 遗传, 2019, 41(7): 644-652.
[2]	何超,沈文龙,李平,张彦,曾晶,殷作明,赵志虎. Alu元件在染色质三维结构层次上的生物信息学分析[J]. 遗传, 2019, 41(3): 254-261.
[3]	孟玉,杨若林. 基于基因家族大小的比较研究脊椎动物的适应性进化[J]. 遗传, 2019, 41(2): 158-174.
[4]	邓雯文,龙梅,杨盛智,邹立扣. β-内酰胺酶耐药基因bla_OKP进化及其侧翼序列特征研究[J]. 遗传, 2018, 40(7): 585-592.
[5]	冯平, 罗瑞健. 灵长类苦味受体基因研究进展[J]. 遗传, 2018, 40(2): 126-134.
[6]	许磊,陈文,司国阳,黄艺园,林毅,蔡永萍,高俊山. 陆地棉GST基因家族全基因组分析[J]. 遗传, 2017, 39(8): 737-752.
[7]	张晓玲,龙芸,葛飞,管中荣,张晓祥,王艳丽,沈亚欧,潘光堂. 玉米幼胚胚性愈伤组织再生能力相关性状遗传研究[J]. 遗传, 2017, 39(2): 143-155.
[8]	蓝洋,胡江涛,张玉娟. 化学计量基因组学研究进展[J]. 遗传, 2017, 39(2): 89-97.
[9]	赵永欣, 李孟华, 赵要风. 中国绵羊起源、进化和遗传多样性研究进展[J]. 遗传, 2017, 39(11): 958-973.
[10]	白东义, 赵一萍, 李蓓, 格日乐其木格, 张心壮, 芒来. 马属动物全基因组高通量测序研究进展[J]. 遗传, 2017, 39(11): 974-983.
[11]	王哲. 植物杂交后代中基因偏分离的产生原因及其进化意义[J]. 遗传, 2016, 38(9): 801-810.
[12]	任丽倩, 刘薇, 李文博, 刘文军, 孙蕾. 脊椎动物Cyclophilin A肽基脯氨酰顺反异构酶活性及遗传变异分析[J]. 遗传, 2016, 38(8): 736-745.
[13]	苏鹏冯少姝李庆伟. NF-кB和IκB在不同动物类群中的结构及功能研究进展[J]. 遗传, 2016, 38(6): 523-531.
[14]	常建忠, 闫凤霞, 乔麟轶, 郑军, 张福耀, 柳青山. 高粱SBP-box基因家族全基因组鉴定及表达分析[J]. 遗传, 2016, 38(6): 569-580.
[15]	吴瑜, 冯旭, 高岚, 焦保卫. 印记基因：发育中的重要调节因子[J]. 遗传, 2016, 38(6): 508-522.