肠球菌万古霉素耐药基因簇遗传特性

doi:10.16288/j.yczz.14-420

遗传 ›› 2015, Vol. 37 ›› Issue (5): 452-457.doi: 10.16288/j.yczz.14-420

肠球菌万古霉素耐药基因簇遗传特性

陈春辉,徐晓刚

复旦大学附属华山医院抗生素研究所,卫生部抗生素临床药理重点实验室,上海 200040

收稿日期:2014-11-29 出版日期:2015-05-20 发布日期:2015-05-20
通讯作者: 徐晓刚,博士,副主任医师,研究方向：病原菌耐药机制。E-mail:xuxiaogang@fudan.edu.cn
作者简介:陈春辉,博士研究生,研究方向：病原菌耐药机制。E-mail:12111220002@fudan.edu.cn
基金资助:
国家自然科学基金项目(编号：81171613)资助

Genetic characteristics of vancomycin resistance gene cluster in Enterococcus spp

Chunhui Chen, Xiaogang Xu

Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China

Received:2014-11-29 Online:2015-05-20 Published:2015-05-20

摘要/Abstract

摘要： 万古霉素耐药肠球菌自20世纪80年代后期被发现以来,已逐渐发展成为重要的医院感染病原菌。此类耐药肠球菌携带的万古霉素耐药基因簇编码产物可催化合成与万古霉素、替考拉宁等糖肽类抗生素亲和力极低的细胞壁前体导致耐药。目前已在肠球菌中发现的万古霉素耐药基因簇根据基因序列及构成不同分为9个型别;依据它们编码的连接酶合成产物不同又可分为D-Ala:D-Lac连接酶基因簇(VanA、VanB、VanD及VanM型)和D-Ala:D-Ser连接酶基因簇(VanC、VanE、VanG、VanL和VanN型)。这些耐药基因簇介导的耐药水平及其传播模式各有特点。文章综述了肠球菌中万古霉素耐药基因簇的类型、基因构成及传播特性。

关键词: 肠球菌属, 万古霉素, 耐药, 基因簇

Abstract: Vancomycin resistant enterococci has become an important nosocomial pathogen since it is discovered in late 1980s. The products, encoded by vancomycin resistant gene cluster in enterococci, catalyze the synthesis of peptidoglycan precursors with low affinity with glycopeptide antibiotics including vancomycin and teicoplanin and lead to resistance. These vancomycin resistant gene clusters are classified into nine types according to their gene sequences and organization, or D-Ala:D-Lac (VanA, VanB, VanD and VanM) and D-Ala:D-Ser (VanC, VanE, VanG, VanL and VanN) ligase gene clusters based on the differences of their encoded ligases. Moreover, these gene clusters are characterized by their different resistance levels and infection models. In this review, we summarize the classification, gene organization and infection model of vancomycin resistant gene cluster in Enterococcus spp.

Key words: Enterococcus spp, vancomycin, resistance, gene cluster

陈春辉,徐晓刚. 肠球菌万古霉素耐药基因簇遗传特性[J]. 遗传, 2015, 37(5): 452-457.

Chunhui Chen, Xiaogang Xu. Genetic characteristics of vancomycin resistance gene cluster in Enterococcus spp[J]. HEREDITAS(Beijing), 2015, 37(5): 452-457.

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肠球菌万古霉素耐药基因簇遗传特性

Genetic characteristics of vancomycin resistance gene cluster in Enterococcus spp

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