the the Doctoral Fund of Ministry of Education of China-Key Program of Priority Fields(20134433130001);the National Natural Science Foundation of China-Guangdong Joint Fund(U1201222)
Yuhua Ye,Qianqian Zhang,Jianmei Zhong,Yihong Li,Li Zhang,Qiuxia Yu,Xiangmin Xu. Analysis of variants in upstream open reading frames of human globin-related genes[J]. Hereditas(Beijing), 2017, 39(3): 232-240.
Hahn CK, Lowrey CH. Induction of fetal hemoglobin through enhanced translation efficiency of γ-globin mRNA. Blood, 2014, 124(17): 2730-2734.
[4]
Akinsheye I, Alsultan A, Solovieff N, Ngo D, Baldwin CT, Sebastiani P, Chui DHK, Steinberg MH. Fetal hemoglobin in sickle cell anemia. Blood, 2011, 118(1): 19-27.
[5]
Van Dijk TB, Gillemans N, Pourfarzad F, van Lom K, von Lindern M, Grosveld F, Philipsen S. Fetal globin expression is regulated by Friend of Prmt1. Blood, 2010, 116(20): 4349-4352.
[6]
Guo XQ. Progress on genes related to fetal hemoglobin quantitative trait. Hereditas (Beijing), 2010, 32(4): 295-300.
Galanello R, Sanna S, Perseu L, Sollaino MC, Satta S, Lai ME, Barella S, Uda M, Usala G, Abecasis GR, Cao A. Amelioration of Sardinian β0 thalassemia by genetic modifiers. Blood, 2009, 114(18): 3935-3937.
[8]
Danjou F, Francavilla M, Anni F, Satta S, Demartis FR, Perseu L, Manca M, Sollaino MC, Manunza L, Mereu E, Marceddu G, Pissard S, Joly P, Thuret I, Origa R, Borg J, Forni GL, Piga A, Lai ME, Badens C, Moi P, Galanello R. A genetic score for the prediction of beta-thalassemia severity. Haematologica, 2015, 100(4): 452-457.
[9]
Danjou F, Anni F, Perseu L, Satta S, Dessì C, Lai ME, Fortina P, Devoto M, Galanello R. Genetic modifiers of β-thalassemia and clinical severity as assessed by age at first transfusion. Haematologica, 2012, 97(7): 989-993.
[10]
Bauer DE, Orkin SH. Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin. Curr Opin Genet Dev, 2015, 33: 62-70.
[11]
Xu J, Bauer DE, Kerenyi MA, Vo TD, Hou S, Hsu YJ, Yao HL, Trowbridge JJ, Mandel G, Orkin SH. Corepressor- dependent silencing of fetal hemoglobin expression by BCL11A. Proc Natl Acad Sci USA, 2013, 110(16): 6518-6523.
[12]
Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell AP, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu C, Kurita R, Nakamura Y, Xu J, Higgs DR, Crossley M, Bauer DE, Orkin SH, Kharchenko PV, Maeda T. Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin. Science, 2016, 351(6270): 285-289.
[13]
Liu D, Zhang XH, Yu LH, Cai R, Ma XX, Zheng CG, Zhou YQ, Liu QJ, Wei XF, Lin L, Yan TZ, Huang JW, Mohandas N, An XL, Xu XM. KLF1 mutations are relatively more common in a thalassemia endemic region