遗传 ›› 2018, Vol. 40 ›› Issue (7): 546-560.doi: 10.16288/j.yczz.18-077

• 综述 • 上一篇    下一篇

结核分枝杆菌酸抗性基因及其调控网络

张沥元,黄芙静,许峻旗,龚真,谢建平()   

  1. 西南大学生命科学学院,三峡库区生态环境与生物资源省部共建国家重点实验室培育基地,现代生物医药研究所,重庆 400715
  • 收稿日期:2018-03-27 修回日期:2018-05-08 出版日期:2018-07-20 发布日期:2018-05-31
  • 作者简介:张沥元,本科,专业方向：生物专业。E-mail:lyzhang9812@foxmail.com|黄芙静,本科,专业方向：生物专业。E-mail:hfjing2015@foxmail.com,张沥元和黄芙静为并列第一作者。
  • 基金资助:
    “国家级大学生创新创业训练计划”项目(201710635064);重庆市教改项目(163024);西南大学教改项目(2016JY050)

Acid-resistant genes in Mycobacterium tuberculosis and the underlying regulatory network

Liyuan Zhang,Fujing Huang,Junqi Xu,Zhen Gong,Jianping Xie()   

  1. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Chongqing 400715, China
  • Received:2018-03-27 Revised:2018-05-08 Online:2018-07-20 Published:2018-05-31
  • Supported by:
    Supported by the National Undergraduate Training Programs for Innovation and Entrepreneurship of China(201710635064);Teaching Reform Project of Chongqing Municipal Education Commission(163024);Teaching Reform Project of Southwest University(2016JY050)

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摘要：

病原菌在宿主细胞内的持留分子机理是目前研究的热点和难点。病原菌的抗酸能力与此密切相关。结核分枝杆菌感染导致的结核病仍然是全球公共卫生的重大威胁,这与结核分枝杆菌抗酸并在宿主巨噬细胞内持留有关。结核分枝杆菌抗酸主要通过调控质子进出、代谢调控胞内酸碱平衡和双组份信号系统调控。本文综述了结核分枝杆菌在酸胁迫下的整体调控网络,阐述了在酸性环境中结核分枝杆菌的具体调控机理,旨在为持留结核分枝杆菌的治疗提供新的全局性思路,寻找新的结核病防控靶标。

关键词: 结核分枝杆菌, 酸抗性基因, 持留, 调控网络

Abstract:

The molecular mechanisms of pathogen persistence within host cells are emerging hotspots, and one of the causes of its persistence is the acid resistance of bacteria. Currently, tuberculosis remains a serious threat to global public health and it is caused by Mycobacterium tuberculosis. In particular, acid resistance of M. tuberculosis and its persistence within macrophages contribute significantly to tuberculosis. Investigations have uncovered three major mechanisms underlying its acid resistance: the control of proton entry, metabolic regulation of intracellular acid-base balance and regulation of the two-component signaling system. In this review, we summarize the overall regulation network of M. tuberculosis in the acidic environment, aiming at providing a new overall idea for treating M. tuberculosis persistence and exploring new targets for tuberculosis control.

Key words: Mycobacterium tuberculosis, acid-resistance related gene, retention, regulatory network