遗传 ›› 2019, Vol. 41 ›› Issue (1): 52-65.doi: 10.16288/j.yczz.18-165

• 综述 • 上一篇    下一篇

抑制植物减数分裂重组的分子机理

李帆1,余蓉培1,孙丹1,王继华1,李绅崇1,阮继伟1,单芹丽1,陆平利2,汪国鲜1   

  1. 1. 云南省农业科学院花卉研究所,国家观赏园艺工程技术研究中心,云南省花卉育种重点实验室,昆明 650200
    2. 复旦大学生命科学学院,植物科学研究所,上海 200433
  • 收稿日期:2018-06-22 修回日期:2018-08-31 出版日期:2019-01-20 发布日期:2018-11-21
  • 作者简介:李帆,博士,助理研究员,研究方向:植物遗传与分子育种。E-mail: lifanla@foxmail.com
  • 基金资助:
    云南省农业联合青年项目,云南省科技计划重点研发(农业领域)项目(编号:2018BB010)和云南省科技计划项目(编号:2016IA001)资助

Molecular mechanisms of meiotic recombination suppression in plants

Li Fan1,Yu Rongpei1,Sun Dan1,Wang Jihua1,Li Shenchong1,Ruan Jiwei1,Shan Qinli1,Lu Pingli2,Wang Guoxian1   

  1. 1. Flower Research Institute, Yunnan Academy of Agricultural Sciences, National Engineering Research Center for Ornamental Horticulture, Yunnan Key Laboratory for Flower Breeding, Kunming 650200, China
    2. Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China
  • Received:2018-06-22 Revised:2018-08-31 Online:2019-01-20 Published:2018-11-21
  • Supported by:
    [Supported by Yunnan Agricultural Joint Youth Project, the Key Research and Development (Agricultural field) Project of Yunnan Science and Technology Program (No. 2018BB010) and the Science and Technology Program of Yunnan Province (No. 2016IA001)]

摘要:

减数分裂重组不仅保证了真核生物有性生殖过程中染色体数量的稳定,还通过父母亲本间遗传物质的互换在后代中产生遗传变异。因此,减数分裂重组是遗传多样性形成的重要途径,也是生物多样性和物种进化的主要动力。在绝大多数真核生物中,不管染色体数目的多少或基因组的大小,减数分裂重组的形成都受到严格的调控,但抑制减数分裂重组的分子机理目前仍不清楚。近年来,通过正向遗传学筛选鉴定出多个减数分裂重组抑制基因,揭示了抑制基因的功能和调控途径。本文基于拟南芥中减数分裂重组抑制基因的研究现状,综述了植物减数分裂重组抑制基因研究取得的突破性进展,并结合基因功能与其调控网络阐述了抑制植物减数分裂重组的分子机理。

关键词: 减数分裂, 同源重组, 抑制基因, 调控网络

Abstract:

Meiotic recombination not only ensures the stability of chromosome numbers during the sexual reproduction in eukaryotes, but also shuffles the maternal and paternal genetic materials to generate genetic diversity in the gametes. Therefore, meiotic recombination is an important pathway for genetic diversity, which has been considered as a major driving force for species evolution and biodiversity in nature. In most eukaryotes, meiotic recombination is strictly limited, despite the large variation of physical genome size and chromosome numbers among species, but the mechanisms suppressing meiotic recombination remain elusive. Recently, several suppressors have been identified through the forward genetics screen, and revealed the functions and regulation pathways of these suppressors. In this review, we summarize the breakthrough discovery of meiotic recombination suppressors in plants based on research in Arabidopsis, with particular focus on the gene function and its regulation network to elucidate the molecular mechanisms of meiotic recombination suppression in plants.

Key words: meiosis, homologous recombination, suppressors, regulation networks