miRNA与肾脏发育

doi:10.16288/j.yczz.20-112

遗传 ›› 2020, Vol. 42 ›› Issue (11): 1062-1072.doi: 10.16288/j.yczz.20-112

miRNA与肾脏发育

赵晓琪, 敖英(), 陈海云, 汪晖

武汉大学基础医学院药理学系,发育源性疾病湖北省重点实验室,武汉 430071

收稿日期:2020-07-16 修回日期:2020-09-30 出版日期:2020-11-20 发布日期:2020-10-15
通讯作者: 敖英 E-mail:yingao@whu.edu.cn
作者简介:赵晓琪,在读硕士研究生,专业方向：肾脏发育毒理。E-mail: xiaoqizhao@whu.edu.cn
基金资助:
国家自然科学基金项目编号(81872943);国家自然科学基金项目编号(81220108026);国家自然科学基金项目编号(81430089);国家自然科学基金项目编号(81001466);湖北省卫计委项目编号(WJ2017M002);湖北省自然科学基金项目资助编号(2017CFB649)

The role of miRNA in kidney development

Xiaoqi Zhao, Ying Ao(), Haiyun Chen, Hui Wang

Hubei Provincial Key Laboratory of Developmentally Originated Diseases, Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China

Received:2020-07-16 Revised:2020-09-30 Online:2020-11-20 Published:2020-10-15
Contact: Ao Ying E-mail:yingao@whu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China Nos(81872943);Supported by the National Natural Science Foundation of China Nos(81220108026);Supported by the National Natural Science Foundation of China Nos(81430089);Supported by the National Natural Science Foundation of China Nos(81001466);Hubei Province health and Family Planning Scientific Research Project No(WJ2017M002);the Natural Science Foundation of Hubei Province No(2017CFB649)

摘要/Abstract

摘要：

MicroRNAs( miRNAs)是一类内源性小非编码RNA (约19~25个核苷酸),主要通过与靶mRNA中的互补靶序列结合,在转录后水平负调节基因表达。miRNA在包括器官发育在内的广泛生物过程中发挥着重要作用。最近研究表明,某些miRNA在肾脏高表达,并与肾脏发育及肾脏疾病密切相关,提示miRNA为肾脏生理学和病理学中的重要调节剂。本综述重点介绍了miRNA在肾脏发育调控中的研究进展,探讨了miRNA在肾脏异常发育的发生发展中起到的作用,为肾脏发育相关疾病的诊断和研究提供参考。

关键词: microRNA, 肾脏发育, 肾脏发育不良, 机制, 诊断

Abstract:

MicroRNAs (miRNAs) are endogenous small non-coding RNAs (19-25 nucleotides) that negatively regulate gene expression at the post transcriptional level by binding to complementary target sequences in the target mRNA. miRNAs play an important role in a wide range of biological processes, including organ development. Recent studies have shown that some miRNAs are highly expressed in the kidney and are closely related to kidney development and diseases, suggesting that miRNAs are important regulators in kidney physiology and pathology. This review will focus on the research progress of miRNA in kidney development, and discuss the role of miRNAs in the occurrence and development of renal dysplasia, which will provide a reference for the diagnosis and research of diseases related to kidney development.

Key words: microRNAs, kidney development, kidney dysplasia, mechanism, diagnosis

赵晓琪, 敖英, 陈海云, 汪晖. miRNA与肾脏发育[J]. 遗传, 2020, 42(11): 1062-1072.

Xiaoqi Zhao, Ying Ao, Haiyun Chen, Hui Wang. The role of miRNA in kidney development[J]. Hereditas(Beijing), 2020, 42(11): 1062-1072.

图/表 2

图1

Table 1

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种属	组织/细胞特异性	敲除靶标	现象	参考文献
非洲爪蟾 (Xenopus laevis)	非肾脏特异性	Dicer、 Dgcr8	肾脏水肿,前肾导管中肾上皮细胞分化延迟,肾形态异常	[16]
小鼠	产生肾素的细胞	Dicer	成年肾脏中近球细胞数量严重减少,出现肾血管疾病和条纹状纤维化	[18]
小鼠	肾单位祖细胞	Dicer	肾单位祖细胞过早耗竭	[19]
小鼠	肾单位和UB来源的集合管系统	Dicer	肾单位祖细胞过早凋亡,UB分支缺陷	[20]
小鼠	肾小管和输尿管芽	Dicer	肾小管分支减少,肾单位减少,双侧肾积水	[21]
小鼠	前肾间充质	Dicer	输尿管芽分支和肾单位祖细胞分化失败	[22]
小鼠	肾祖细胞及其衍生物	miR-17~ 92	肾单位数量减少,出生后发展为肾小球功能障碍和蛋白尿性肾脏疾病。	[23]
小鼠	泌尿生殖道和肾小管系统	Dgcr8	出生后两个月内出现严重肾积水,肾囊肿,进行性肾衰竭	[24]
小鼠	肾脏基质细胞	Dicer1	肾脏发育不良,肾小管和脉管系统异常分化	[25]

miRNA与肾脏发育

The role of miRNA in kidney development

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