遗传 ›› 2024, Vol. 46 ›› Issue (6): 438-451.doi: 10.16288/j.yczz.24-095

• 特邀综述 • 上一篇    下一篇

支链氨基酸代谢在肿瘤发生发展中的作用

沈院(), 李金涛, 尹淼, 雷群英()   

  1. 复旦大学附属肿瘤医院,肿瘤研究所,上海 200032
  • 收稿日期:2024-04-03 修回日期:2024-05-27 出版日期:2024-06-20 发布日期:2024-05-28
  • 通讯作者: 雷群英 E-mail:yuanshen20@fudan.edu.cn;qlei@fudan.edu.cn
  • 作者简介:沈院,博士研究生,专业方向:营养与肿瘤代谢。E-mail: yuanshen20@fudan.edu.cn
  • 基金资助:
    国家重点研发计划项目(2020YFA0803402);国家重点研发计划项目(2019YFA0801703);国家自然科学基金项目(82121004);国家自然科学基金项目(82330092);上海市教委创新计划项目(2023ZKZD11);上海市科技重大专项和新基石科学基金资助

The roles of branched-chain amino acids metabolism in tumorigenesis and progression

Yuan Shen(), Jintao Li, Miao Yin, Qunying Lei()   

  1. Fudan University Shanghai Cancer Center, Cancer Institutes, Shanghai 200032, China
  • Received:2024-04-03 Revised:2024-05-27 Published:2024-06-20 Online:2024-05-28
  • Contact: Qunying Lei E-mail:yuanshen20@fudan.edu.cn;qlei@fudan.edu.cn
  • Supported by:
    National Key R&D Program of China(2020YFA0803402);National Key R&D Program of China(2019YFA0801703);Natural Science Foundation of China(82121004);Natural Science Foundation of China(82330092);Innovation Program of Shanghai Municipal Education Commission(2023ZKZD11);Shanghai Municipal Science and Technology Major Project, and the New Cornerstone Science Foundation

摘要:

支链氨基酸(branched-chain amino acids,BCAAs),包括亮氨酸、缬氨酸和异亮氨酸,在调节体内代谢平衡、维持正常生命活动中发挥着重要作用。许多研究报道了它们在肥胖、糖尿病和心血管等疾病中的代谢和功能。近些年研究表明,BCAAs代谢在肿瘤发生发展中也起着重要作用。本文综述了BCAAs代谢在该方面的研究进展,包括与表观遗传调控的关系,特别是围绕肿瘤代谢重塑和代谢感知,讨论了其在肿瘤细胞和肿瘤微环境(tumor microenvironment,TME)中的作用。深入了解BCAAs代谢在肿瘤发生发展中的作用及其机制有助于为开发新的肿瘤治疗策略提供理论基础。

关键词: 支链氨基酸, 肿瘤细胞, 肿瘤微环境, 代谢感知, 代谢重塑, 表观遗传

Abstract:

Branched-chain amino acids (BCAAs), including leucine, valine, and isoleucine, play crucial roles in regulating metabolic balance and maintaining physiological functions in the body. Extensive studies have been focused on their implications in obesity, diabetes, and cardiovascular diseases. Nevertheless, accumulating evidence suggests that BCAAs metabolism also plays significant roles in tumorigenesis and progression. In this review, we overview recent progress of the study on BCAAs metabolism including its relationship with epigenetic regulation. Particularly, we discuss the metabolic reprogramming and metabolic sensing of BCAAs and its intermediate metabolites in tumor cells and microenvironment to decipher their functions. An enhanced understanding of the roles and mechanism of BCAAs metabolism in tumorigenesis and progression will contribute to development of novel therapeutic strategies against tumor.

Key words: BCAAs, tumor cells, tumor microenvironment, metabolic sensing, metabolic reprogramming, epigenetics