表观遗传对炎症的调控机制及其在奶牛乳房炎抗病育种中的应用前景

doi:10.3724/SP.J.1005.2010.00663

遗传 ›› 2010, Vol. 32 ›› Issue (7): 663-669.doi: 10.3724/SP.J.1005.2010.00663

表观遗传对炎症的调控机制及其在奶牛乳房炎抗病育种中的应用前景

王晓铄, 俞英

中国农业大学动物科技学院, 北京 100193

收稿日期:2009-10-25 修回日期:2010-03-02 出版日期:2010-07-20 发布日期:2010-07-20
通讯作者: 俞英 E-mail:yuyingmaryland@yahoo.com
基金资助:
国家高技术研究发展计划项目(863计划)(编号：2008AA101002, 2008BADB2B03-05)和“948”项目(编号：2006-G48(3))资助

Regulation mechanisms of epigenetics on inflammation and its per-spective on breeding for mastitis resistance in dairy cattle

WANG Xiao-Shuo, YU Ying

College of Animal Science and Technology, China Agricultural University, Beijing 100193, China

Received:2009-10-25 Revised:2010-03-02 Online:2010-07-20 Published:2010-07-20
Contact: Ying Yu E-mail:yuyingmaryland@yahoo.com

摘要/Abstract

摘要： 炎症受遗传和非遗传因素(环境或表观遗传)的共同影响, 其中表观遗传(Epigenetic)在炎症的发生发展过程中发挥重要调控作用。表观遗传修饰是指DNA序列没有改变, 而基因表达却发生了可遗传的变化, 主要包括DNA甲基化和组蛋白修饰等。表观遗传为病原微生物与炎症反应间关系的研究架起了重要桥梁。炎症反应中T辅助细胞的分化, 细胞因子、趋化因子等基因的表达都受到表观遗传的调控。文章主要综述了DNA甲基化、组蛋白修饰等对炎症尤其是乳房炎的调控机制, 并就表观遗传调控在奶牛乳房炎治疗及抗病育种中的应用前景进行了展望。

关键词: 炎症, 表观遗传, 乳房炎, 抗病育种

Abstract: Inflammation is controlled by genetic and non-genetic factors (environment and epigenetics), within non-genetic factors, epigenetics play important roles in the development of inflammation. Epigenetic modifications, referring to changes in phenotype or gene expression caused by mechanisms other than changes in the underlying DNA sequence, mainly include DNA methylation and histone modification. Epigenetic study builds up the relationships between microorganism and inflammation. In inflammation responses, differentiation of T helper cells and gene expression of cytokine and chemokine are all regulated by epigenetics. Here, we reviewed the regulation mechanisms of DNA methylation and histone modifications on inflammation, especially on cow mastitis. The progress and application trends of epigenetics on treatment of mastitis and breeding for mastitis resistance in dairy cattle are also discussed.

Key words: Inflammation, epigenetics, mastitis, breeding for disease resistance

王晓铄，俞英. 表观遗传对炎症的调控机制及其在奶牛乳房炎抗病育种中的应用前景[J]. 遗传, 2010, 32(7): 663-669.

WANG Xiao-Li, SHU Yang. Regulation mechanisms of epigenetics on inflammation and its per-spective on breeding for mastitis resistance in dairy cattle[J]. HEREDITAS, 2010, 32(7): 663-669.

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表观遗传对炎症的调控机制及其在奶牛乳房炎抗病育种中的应用前景

Regulation mechanisms of epigenetics on inflammation and its per-spective on breeding for mastitis resistance in dairy cattle

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