遗传 ›› 2023, Vol. 45 ›› Issue (2): 99-114.doi: 10.16288/j.yczz.22-310

• 综述 • 上一篇    下一篇

核受体REV-ERBα整合生物钟与能量代谢

冒姝羽1(), 赵昌睿1, 刘畅1,2()   

  1. 1.中国药科大学生命科学与技术学院,南京 211198
    2.重庆中国药科大学创新研究院,重庆 401135
  • 收稿日期:2022-09-26 修回日期:2022-11-09 出版日期:2023-02-20 发布日期:2022-11-23
  • 通讯作者: 刘畅 E-mail:3220030438@stu.cpu.edu.cn;changliu@cpu.edu.cn
  • 作者简介:冒姝羽,在读硕士研究生,专业方向:细胞生物学。E-mail: 3220030438@stu.cpu.edu.cn
  • 基金资助:
    国家自然科学基金(92057112);国家重点研发计划(2021YFF0702000)

The nuclear receptor REV-ERBα integrates circadian clock and energy metabolism

Shuyu Mao1(), Changrui Zhao1, Chang Liu1,2()   

  1. 1. School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China
    2. Chongqing Innovation Institute of China Pharmaceutical University, Chongqing 401135, China
  • Received:2022-09-26 Revised:2022-11-09 Online:2023-02-20 Published:2022-11-23
  • Contact: Liu Chang E-mail:3220030438@stu.cpu.edu.cn;changliu@cpu.edu.cn
  • Supported by:
    the National Natural Science Foundation of China(92057112);the National Key Research and Development Program of China(2021YFF0702000)

摘要:

哺乳动物的各项生理活动以24 h为周期呈现节律性变化。稳定的昼夜节律由生物钟系统所精细调控,而昼夜节律的紊乱会导致代谢性疾病的发生。核受体超家族成员REV-ERBα是哺乳动物生物钟的重要组成部分,参与代谢、炎症、免疫和昼夜节律等多种生理过程的调节,是代谢性疾病、炎症性疾病和癌症的潜在治疗靶点。近年来发现了一系列新的REV-ERBα配体,其中大部分在疾病治疗方面具有潜在的应用价值。本文主要介绍核受体REV-ERBα在能量代谢以及炎症反应中的调节作用,以期为代谢综合征及相关疾病的治疗提供新的策略和参考。

关键词: REV-ERBα, 代谢, 炎症, REV-ERBα配体

Abstract:

The physiological processes of mammals show rhythmic changes in a 24-h cycle. Circadian rhythms are under the subtle control of the autonomous circadian clock, and dysregulation of the circadian system can lead to health problems such as metabolic disorders. REV-ERBα, a member of the nuclear receptor superfamily, is an important component of the mammalian circadian clock. REV-ERBα regulates various physiological processes, including the regulation of metabolism, inflammation and immunity as well as the circadian rhythm, making it a potential therapeutic target for metabolic syndrome, inflammatory diseases and cancers. In recent years, an array of new REV-ERBα ligands have been discovered, most of which have potential applications in the treatment of diseases. In this review, we focus on the regulatory role of nuclear receptor REV-ERBα in energy metabolism and inflammation, in order to provide new strategies for the therapy of metabolic syndrome and its related diseases.

Key words: REV-ERBα, metabolism, inflammation, REV-ERBα ligands