人类白细胞抗原与鼻咽癌的相关性

doi:10.3724/SP.J.1005.2012.01505

遗传 ›› 2012, Vol. 34 ›› Issue (12): 1505-1512.doi: 10.3724/SP.J.1005.2012.01505

• 综述 • 下一篇

人类白细胞抗原与鼻咽癌的相关性

汤敏中^1,2, 蔡永林², 郑裕明², 曾毅^1,3

1. 北京工业大学生命科学与生物工程学院, 北京100124 2. 广西壮族自治区梧州市红十字会医院, 梧州市卫生系统鼻咽癌病因学及分子机理重点实验室, 梧州543002 3. 中国疾病预防控制中心, 传染病预防控制国家重点实验室, 北京100052

收稿日期:2012-03-23 修回日期:2012-04-24 出版日期:2012-12-20 发布日期:2012-12-25
通讯作者: 曾毅 E-mail:zengy@public.bta.net.cn
基金资助:
美国国立卫生院国立癌症研究所项目(编号：N01-CO-12400), 广西科技计划项目(编号：114003A-49)和梧州市科技计划项目(编号：201102062)资助

Association between human leukocyte antigenand nasopharyngeal-carcinoma

TANG Min-Zhong^1,2, CAI Yong-Lin², ZHENG Yu-Ming², ZENG Yi^1,3

1. College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, China 2. Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou Red Cross Hospital, Wuzhou 543002, China 3. State Key Laboratory for Infectious Diseases Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China

Received:2012-03-23 Revised:2012-04-24 Online:2012-12-20 Published:2012-12-25

摘要/Abstract

摘要： 鼻咽癌是一种多因素影响的复杂性疾病, 其发病具有显著的地理分布差异。Epstein-Barr(EB)病毒感染与鼻咽癌发病密切相关已得到公认, 但环境因素及遗传因素在鼻咽癌的发病中也具有重要作用。在鼻咽癌的遗传相关因素中, 位于6号染色体上具有高度多态性的人类白细胞抗原(Human leukocyte antigen, HLA)与鼻咽癌发病风险相关在多个研究组中被报道。随着DNA测序技术的发展, 高分辨基因分型技术的应用, HLA新等位基因数目呈指数级的上升, 更多的HLA全基因序列被研究者所报道。近年来, 等位基因关联性分析、微卫星连锁不平衡分析及全基因组关联性分析的研究结果均证实了6号染色体HLA区域与鼻咽癌具有显著关联。为了进一步探讨遗传相关性因子HLA在鼻咽癌发生发展中的作用, 文章着重综述了HLA与鼻咽癌相关性研究的最新进展, 为鼻咽癌HLA相关性研究提供新的思路。

关键词: 鼻咽癌, 人类白细胞抗原, 多态性, 相关性研究

Abstract: Nasopharyngeal carcinoma (NPC) is characterized by its distinct racial and geographical distribution with a multifactorial etiology. It has been well accepted that NPC is related to Epstein-Barr(EB) virus infection but environmental and genetics factors also play critical roles. Among host genetic markers associated with NPC, the highly variable class I human leukocyte antigen (HLA) genes on chromosome 6 (6p21.3) have shown a strong and consistent association with NPC risk. As the consequence of new generation DNA sequencing technologies used in HLA genotyping, the number of the reported HLA new alleles is dramaticllyincreasing, and more full length sequences of HLA alleles have been reported. The significant association between HLA genes and NPC has been identifiedin a series of studies, including HLA association study, linkage disequilibrium study for microsatellite markers, and genome wide association study. In this review, we summarize association studies between HLA and NPC to evaluate the role of genetic polymorphisms in NPC development and illustrate the new clues of HLA association for deepexploration.

Key words: nasopharyngeal carcinoma, HLA, polymorphism, association study

汤敏中，蔡永林，郑裕明，曾毅. 人类白细胞抗原与鼻咽癌的相关性[J]. 遗传, 2012, 34(12): 1505-1512.

TANG Min-Zhong CAI Yong-Lin ZHENG Yu-Ming ZENG Yi. Association between human leukocyte antigenand nasopharyngeal-carcinoma[J]. HEREDITAS, 2012, 34(12): 1505-1512.

参考文献

[1] Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin, 2011, 61(2): 69-90.
[2] Ng WT, Yau TK, Yung RW, Sze WM, Tsang AH, Law AL, Lee AW. Screening for family members of patients with nasopharyngeal carcinoma. Int J Cancer, 2005, 113(6): 998-1001.
[3] Sun LM, Epplein M, Li CI, Vaughan TL, Weiss NS. Trends in the incidence rates of nasopharyngeal carcinoma among Chinese Americans living in Los Angeles County and the San Francisco metropolitan area, 1992-2002. Am J Epidemiol, 2005, 162(12): 1174-1178.
[4] Simons MJ, Day NE, Wee GB, Shanmugaratnam K, Ho HC, Wong SH, Ti TK, Yong NK, Darmalingam S, De Thé G. Nasopharyngeal carcinoma V: immunogenetic studies of Southeast Asian ethnic groups with high and low risk for the tumor. Cancer Res, 1974, 34(5): 1192-1195.
[5] Chan SH, Day NE, Kunaratnam N, Chia KB, Simons MJ. HLA and nasopharyngeal carcinoma in Chinese--a further study. Int J Cancer, 1983, 32(2): 171-176.
[6] Hildesheim A, Apple RJ, Chen CJ, Wang SS, Cheng YJ, Klitz W, Mack SJ, Chen IH, Hsu MM, Yang CS, Brinton LA, Levine PH, Erlich HA. Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan. J Natl Cancer Inst, 2002, 94(23): 1780-1789.
[7] Tang M, Zeng Y, Poisson A, Marti D, Guan L, Zheng Y, Deng H, Liao J, Guo X, Sun S, Nelson G, de Thé G, Winkler CA, O'Brien SJ, Carrington M, Gao X. Haplotype-dependent HLA susceptibility to nasopharyngeal carcinoma in a Southern Chinese population. Genes Immun, 2010, 11(4): 334-342.
[8] Lu SJ, Day NE, Degos L, Lepage V, Wang PC, Chan SH, Simons M, McKnight B, Easton D, Zeng Y. Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA regions. Nature, 1990, 346(6283): 470-471.
[9] 曾毅. 遗传因素、环境因素及EB病毒在鼻咽癌发生中作用的研究. 中国肿瘤, 1995, 4(3): 24-25.
[10] Liu ZS, Liu YF, Zeng Y. Synergistic effect of Epstein-Barr virus and tumor promoters on induction of lymphoma and carcinoma in nude mice. J Cancer Res Clin Oncol, 1998, 124(10): 541-548.
[11] Duquesnoy RJ. A structurally based approach to determine HLA compatibility at the humoral immune level. Hum Immunol, 2006, 67(11): 847-862.
[12] Heemels MT, Ploegh H. Generation, translocation, and presentation of MHC class I-restricted peptides. Annu Rev Biochem, 1995, 64: 463-491.
[13] Adams SD, Barracchini KC, Simonis TB, Stroncek D, Marincola FM. High throughput HLA sequence-based typing (SBT) utilizing the ABI Prism 3700 DNA Analyzer. Tumori, 2001, 87(2): S40-S43.
[14] Cox ST, McWhinnie AJ, Robinson J, Marsh SGE, Parham P, Madrigal JA, Little AM. Cloning and sequencing full-length HLA-B and -C genes. Tissue Antigens, 2003, 61(1): 20-48.
[15] 闫春霞, 宋艳萍, 赖淑苹, 赖江华, 张洪波, 赵君海, 李生斌. 应用PCR-SSOP技术研究中国汉族、维吾尔族HLA-A基因座基因多态性. 遗传学报, 2002, 29(5): 384-389.
[16] Baines M, Ebringer A. HLA and disease. Mol Aspects Med, 1992, 13(4): 263-378.
[17] Hildesheim A, Wang CP. Genetic predisposition factors and nasopharyngeal carcinoma risk: a review of epidemiological association studies, 2000-2011: Rosetta Stone for NPC: genetics, viral infection, and other environmental factors. Semin Cancer Biol, 2012, 22(2): 107-116.
[18] Zhao ML, Cai HB, Li X, Zheng H, Yang XX, Fang WY, Zhang LC, Wei GG, Li M, Yao KT, Li X. Further evidence for the existence of major susceptibility of nasopharyngeal carcinoma in the region near HLA-A locus in Southern Chinese. J Transl Med, 2012, 10(1): 57.
[19] Ghandri N, Gabbouj S, Farhat K, Bouaouina N, Abdelaziz H, Nouri A, Chouchane L, Hassen E. Association of HLA-G polymorphisms with nasopharyngeal carcinoma risk and clinical outcome. Hum Immu-nol, 2011, 72(2): 150-158.
[20] Lind C, Ferriola D, Mackiewicz K, Heron S, Rogers M, Slavich L, Walker R, Hsiao T, McLaughlin L, D'Arcy M, Gai X, Goodridge D, Sayer D, Monos D. Next-generation sequencing: the solution for high-resolution, unambiguous human leukocyte antigen typing. Hum Immunol, 2010, 71(10): 1033-1042.
[21] Erlich RL, Jia XM, Anderson S, Banks E, Gao XJ, Carrington M, Gupta N, DePristo MA, Henn MR, Lennon NJ, de Bakker PI. Next-generation sequencing for HLA typing of class I loci. BMC Genomics, 2011, 12: 42.
[22] Holcomb CL, Höglund B, Anderson MW, Blake LA, Böhme I, Egholm M, Ferriola D, Gabriel C, Gelber SE, Goodridge D, Hawbecker S, Klein R, Ladner M, Lind C, Monos D, Pando MJ, Proll J, Sayer DC, Schmitz-Agheguian G, Simen BB, Thiele B, Trachtenberg EA, Tyan DB, Wassmuth R, White S, Erlich HA. A multi-site study using high-resolution HLA genotyping by next generation sequencing. Tissue Antigens, 2011, 77(3): 206-217.
[23] Robinson JMK, McWilliam H, Lopez R, Parham P, Marsh SGE. The IMGT/HLA Database. Nuclei Aci Res, 2011, 39(Supp1.): D1171-D1176.
[24] 徐筠娉, 邓志辉, 邹红岩, 高素青, 王大明, 何柳媚, 魏天莉. 中国汉族个体HLA-A、-B基因全长序列的测定及调控区多态性. 遗传, 2010, 32(7): 685-693.
[25] 曾健强, 徐筠娉, 王大明, 高素青, 邹红岩, 邓志辉. 汉族人群中22个HLA-Cw等位基因全长序列单核苷酸多态性分析. 遗传, 2010, 32(5): 473-479.
[26] Wu SB, Hwang SJ, Chang AS, Hsieh T, Hsu MM, Hsieh RP, Chen CJ. Human leukocyte antigen (HLA) frequency among patients with nasopharyngeal carcinoma in Taiwan. Anticancer Res, 1989, 9(6): 1649-1653.
[27] Lu CC, Chen JC, Jin YT, Yang HB, Chan SH, Tsai ST. Genetic susceptibility to nasopharyngeal carcinoma within the HLA-A locus in Taiwanese. Int J Cancer, 2003, 103(6): 745-751.
[28] Pimtanothai N, Kangwanshiratada O, Charoenwongse P. Serological analysis of human leukocyte antigens-A and -B antigens in Thai patients with nasopharyngeal carcinoma. J Med Assoc Thai, 2003, 86(Suppl. 2): S237-S241.
[29] Hu SP, Day NE, Li DR, Luben RN, Cai KL, Ou-Yang T, Li B, Lu XZ, Ponder BA. Further evidence for an HLA-related recessive mutation in nasopharyngeal carcinoma among the Chinese. Br J Cancer, 2005, 92(5): 967-970.
[30] Goldsmith DB, West TM, Morton R. HLA associations with nasopharyngeal carcinoma in Southern Chinese: a meta-analysis. Clin Otolaryngol Allied Sci, 2002, 27(1): 61-67.
[31] Middleton D, Menchaca L, Rood H, Komerofsky R. New allele frequency database: http://www.allelefrequencies. net. Tissue Antigens, 2003, 61(5): 403-407.
[32] Makni H, Daoud J, Ben Salah H, Mahfoudh N, Haddar O, Karray H, Boudawara T, Ghorbel A, Khabir A, Frikha M. HLA association with nasopharyngeal carcinoma in southern Tunisia. Mol Biol Rep, 2010, 37(5): 2533-2539.
[33] Burt RD, Vaughan TL, McKnight B, Davis S, Beckmann AM, Smith AG, Nisperos B, Swanson GM, Berwick M. Associations between human leukocyte antigen type and nasopharyngeal carcinoma in Caucasians in the United States. Cancer Epidemiol Biomarkers Prev, 1996, 5(11): 879-887.
[34] Yu KJ, Gao XJ, Chen CJ, Yang XR, Diehl SR, Goldstein A, Hsu WL, Liang XS, Marti D, Liu MY, Chen JY, Carrington M, Hildesheim A. Association of human leukocyte antigens with nasopharyngeal carcinoma in high-risk multiplex families in Taiwan. Hum Immunol, 2009, 70(11): 910-914.
[35] Chan SH, Day NE, Khor TH, Kunaratnam N, Chia KB, Simons MJ. Nasopharyngeal carcinoma // Grundmann E, Krueger GRF, Ablashi DV, Eds, Cancer Campaign Volume 5: Nasopharyngeal carcinoma. Stuttgart: Gustav Fischer Verlag, 1981, 5: 205-211.
[36] 区宝祥, 阮华业, 方嬿, 刘丽梅, 李振权, 张锋. 广州地区HLA-A、B、C、DR与鼻咽癌关联的研究. 癌症, 1985, 4(1): 5-8.
[37] Simons MJ, Wee GB, Chan SH, Shanmugaratnam K, Day NE, de Thé G. Immunogenetic aspects of nasopharyngeal carcinoma (NPC) III. HL-a type as a genetic marker of NPC predisposition to test the hypothesis that Epstein-Barr virus is an etiological factor in NPC. IARC Sci Publ, 1975, (11 Pt 2): 249-258.
[38] Simons MJ, Wee GB, Singh D, Dharmalingham S, Yong NK, Chau JC, Ho JH, Day NE, de Thé G. Immunogenetic aspects of nasopharyngeal carcinoma. V. Confirmation of a Chinese-related HLA profile (A2, Singapore 2) associated with an increased risk in Chinese for nasopharyngeal carcinoma. Natl Cancer Inst Monogr, 1977, 47: 147-151.
[39] Ooi EE, Ren EC, Chan SH. Association between microsatellites within the human MHC and nasopharyngeal carcinoma. Int J Cancer, 1997, 74(2): 229-232.
[40] Chan SH, Chew CT, Prasad U, Wee GB, Srinivasan N, Kunaratnam N. HLA and nasopharyngeal carcinoma in Malays. Br J Cancer, 1985, 51(3): 389-392.
[41] Lee LK, Tan EL, Gopala K, Sam CK. Human leukocyte class I antigen alleles A2 and A11 are not associated with nasopharyngeal carcinoma in West Malaysia. Singapore Med J, 2007, 48(7): 632-634.
[42] 吴国光, 邓志辉, 高素青, 程良红, 金士正, 周丹, 李桢, 邹红岩, 张旋, 魏天莉, 程曦, 王大明. 6965名汉族骨髓供者HLA多态性分析. 中华血液学杂志, 2004, 25(8): 27-31.
[43] 袁方, 孙玉英, 骆媛, 梁飞, 刘楠, 金荔, 刘金锋, 刘曙光, 奚永志. 我国汉族人群HLAⅠ类经典基因单倍型及连锁分析. 中国实验血液学杂志, 2007, 15(5): 1084-1089.
[44] Betuel H, Camoun M, Colombani J, Day NE, Ellouz R, de Thé G. The relationship between nasopharyngeal carcinoma and the HL-A system among Tunisians. Int J Can-cer, 1975, 16(2): 249-254.
[45] Dardari R, Khyatti M, Jouhadi H, Benider A, Ettayebi H, Kahlain A, Mansouri A, El Gueddari B, Benslimane A. Study of human leukocyte antigen class I phenotypes in Moroccan patients with nasopharyngeal carcinoma. Int J Cancer, 2001, 92(2): 294-297.
[46] Reveille JD, Ball EJ, Khan MA. HLA-B27 and genetic predisposing factors in spondyloarthropathies. Curr Opin Rheumatol, 2001, 13(4): 265-272.
[47] Gonzalez-Galarza FF, Christmas S, Middleton D, Jones AR. Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations. Nucleic Acids Res, 2011, 39(Database issue): D913-D919.
[48] Li PKT, Poon AS, Tsao SY, Ho S, Tam JS, So AK, Lai KN. No association between HLA-DQ and -DR genotypes with nasopharyngeal carcinoma in southern Chinese. Cancer Genet Cytogenet, 1995, 81(1): 42-45.
[49] 周劲峰, 郭实士, 余平. 湖南汉族人群HLA-DP、-DQ位点等位基因多态性与鼻咽癌的相关性. 中华医学遗传学杂志, 2003, 20(3): 90-92.
[50] 王志鹏, 郭实士, 余平. 湖南汉族人群HLA-DR位点等位基因多态性与鼻咽癌的相关性研究. 中国病理生理杂志, 2005, 21(5): 1014-1015, 1025.
[51] 王培, 邹华, 丁琳, 陈秋坚, 郑亿庆, 吴玉萍, 徐安龙, 刘宜敏, 孔月萍. 广东汉族鼻咽癌与DPB1-3'调控区多态性相关研究. 临床耳鼻咽喉头颈外科杂志, 2010, 24(6): 261-263.
[52] Kulkarni S, Savan R, Qi Y, Gao XJ, Yuki Y, Bass SE, Martin MP, Hunt P, Deeks SG, Telenti A, Pereyra F, Goldstein D, Wolinsky S, Walker B, Young HA, Carrington M. Differential microRNA regulation of HLA-C expression and its association with HIV control. Nature, 2011, 472(7344): 495-498.
[53] Dorak MT. Role of natural killer cells and killer immunoglobulin-like receptor polymorphisms: association of HLA and KIRs. Methods Mol Med, 2007, 134: 123-144.
[54] Moretta L, Moretta A. Killer immunoglobulin-like receptors. Curr Opin Immunol, 2004, 16(5): 626-633.
[55] Khakoo SI, Thio CL, Martin MP, Brooks CR, Gao XJ, Astemborski J, Cheng J, Goedert JJ, Vlahov D, Hilgartner M, Cox S, Little AM, Alexander GJ, Cramp ME, O'Brien SJ, Rosenberg WM, Thomas DL, Carrington M. HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science, 2004, 305(5685): 872-874.
[56] Naumova E, Mihaylova A, Stoitchkov K, Ivanova M, Quin L, Toneva M. Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals. Cancer Immunol Immunother, 2005, 54(2): 172-178.
[57] Mingari MC, Ponte M, Vitale C, Bellomo R, Moretta L. Expression of HLA class I-specific inhibitory receptors in human cytolytic T lymphocytes: a regulated mechanism that controls T-cell activation and function. Hum Immunol, 2000, 61(1): 44-50.
[58] Butsch Kovacic M, Martin M, Gao X, Fuksenko T, Chen CJ, Cheng YJ, Chen JY, Apple R, Hildesheim A, Carrington M. Variation of the killer cell immunoglobulin-like receptors and HLA-C genes in nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev, 2005, 14(11 Pt 1): 2673-2677.
[59] 卢亮, 金士正, 王大明, 高素青, 邓志辉. 杀伤细胞免疫球蛋白样受体基因多样性与中国南方汉族人群鼻咽癌相关性的研究. 中国实验血液学杂志, 2011, 19(3): 798-800.
[60] Lu CC, Chen JC, Tsai ST, Jin YT, Tsai JC, Chan SH, Su IJ. Nasopharyngeal carcinoma-susceptibility locus is localized to a 132 kb segment containing HLA-A using high-resolution microsatellite mapping. Int J Cancer, 2005, 115(5): 742-746.
[61] Consortium TWTCC. Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls. Nature, 2007, 447(7145): 661-678.
[62] Feero WG, Guttmacher AE, Manolio TA. Genomewide association studies and assessment of the risk of disease. N Engl J Med, 2010, 363(2): 166-176.
[63] Ng CC, Yew PY, Puah SM, Krishnan G, Yap LF, Teo SH, Lim PV, Govindaraju S, Ratnavelu K, Sam CK, Takahashi A, Kubo M, Kamatani N, Nakamura Y, Mushiroda T. A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma. J Hum Genet, 2009, 54(7): 392-397.
[64] Tse KP, Su WH, Chang KP, Tsang NM, Yu CJ, Tang P, See LC, Hsueh C, Yang ML, Hao SP, Li HY, Wang MH, Liao LP, Chen LC, Lin SR, Jorgensen TJ, Chang YS, Shugart YY. Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21. 3. Am J Hum Genet, 2009, 85(2): 194-203.
[65] Bei JX, Li Y, Jia WH, Feng BJ, Zhou GQ, Chen LZ, Feng QS, Low HQ, Zhang HX, He FC, Tai ES, Kang TB, Liu ET, Liu JJ, Zeng YX. A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nat Genet, 2010, 42(7): 599-603.

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

人类白细胞抗原与鼻咽癌的相关性

Association between human leukocyte antigenand nasopharyngeal-carcinoma

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	梁文权,侯豫,赵存友. 精神分裂症相关单核苷酸多态性调控microRNA功能研究进展[J]. 遗传, 2019, 41(8): 677-685.
[2]	张晴,平杰,张昊翔,康波,李元丰,周钢桥. MKL1基因多态性与高原环境适应性的遗传关联研究[J]. 遗传, 2019, 41(7): 634-643.
[3]	陈应坚,廖苑君,林帆,孙胜南,赵小蕾,覃继恒,饶绍奇. 基于转录组数据的网络分析挖掘鼻咽癌与口腔鳞癌的共享功能模块[J]. 遗传, 2019, 41(2): 146-157.
[4]	张婕妤,初亚男,邹秉杰,张晏洁,封利颖. 基于级联核酸侵入反应的real-time PCR法检测咽拭子样本中UGT1A16*基因多态性[J]. 遗传, 2018, 40(8): 668-675.
[5]	彭哲也,唐紫珺,谢民主. 机器学习方法在基因交互作用探测中的研究进展[J]. 遗传, 2018, 40(3): 218-226.
[6]	刘莉莉, 郭爱伟, 吴培福, 陈粉粉, 杨亚晋, 张勤. 敲降VPS28基因对中国荷斯坦奶牛乳脂合成的调控[J]. 遗传, 2018, 40(12): 1092-1100.
[7]	杨熳,卢冰婕,段媛媛,陈晓峰,马建岗,郭燕. 骨质疏松症易感基因BDNF的遗传学关联分析及功能研究[J]. 遗传, 2017, 39(8): 726-736.
[8]	张统雨,朱才业,杜立新,赵福平. 羊重要性状全基因组关联分析研究进展[J]. 遗传, 2017, 39(6): 491-500.
[9]	王诗铭, 宋晓, 赵雪莹, 陈红岩, 王久存, 吴俊杰, 高志强, 钱吉, 白春学, 李强, 韩宝惠, 卢大儒. 自噬通路基因多态性与晚期非小细胞肺癌含铂化疗疗效的相关性分析[J]. 遗传, 2017, 39(3): 250-262.
[10]	王本刚, 吕执, 徐倩, 刘永锋. 多NER基因多态的交互作用与移植排斥的发病风险相关[J]. 遗传, 2017, 39(1): 22-31.
[11]	符梅, 徐克惠, 许文明. Dicer调节生殖功能的研究进展[J]. 遗传, 2016, 38(7): 612-622.
[12]	弓弦,张超,伊利亚斯·艾萨,时瑛,杨雪唯,努尔斯曼古丽奥斯曼,关亚群,徐书华. 2型糖尿病易感候选基因在世界不同人群中的多样性比较分析[J]. 遗传, 2016, 38(6): 543-559.
[13]	刘振, 徐建红. 高通量测序技术在转座子研究中的应用[J]. 遗传, 2015, 37(9): 885-898.
[14]	阮修艳, 王伟妮, 杨雅冉, 谢兵兵, 陈婧, 刘雅诚, 严江伟. 北京汉族群体39个短串联重复序列基因座多态性及其遗传关系[J]. 遗传, 2015, 37(7): 683-691.
[15]	刘霞, 张斌, 毛新国, 李昂, 孙美荣, 景蕊莲. 小麦tae-MIR156前体基因的克隆及其靶基因TaSPL17多态性分析[J]. 遗传, 2014, 36(6): 592-602.