人类白细胞抗原与鼻咽癌的相关性

doi:10.3724/SP.J.1005.2012.01505

遗传 ›› 2012, Vol. 34 ›› Issue (12): 1505-1512.doi: 10.3724/SP.J.1005.2012.01505

• 综述 • 下一篇

人类白细胞抗原与鼻咽癌的相关性

汤敏中^1,2, 蔡永林², 郑裕明², 曾毅^1,3

1. 北京工业大学生命科学与生物工程学院, 北京100124 2. 广西壮族自治区梧州市红十字会医院, 梧州市卫生系统鼻咽癌病因学及分子机理重点实验室, 梧州543002 3. 中国疾病预防控制中心, 传染病预防控制国家重点实验室, 北京100052

收稿日期:2012-03-23 修回日期:2012-04-24 出版日期:2012-12-20 发布日期:2012-12-25
通讯作者: 曾毅 E-mail:zengy@public.bta.net.cn
基金资助:
美国国立卫生院国立癌症研究所项目(编号：N01-CO-12400), 广西科技计划项目(编号：114003A-49)和梧州市科技计划项目(编号：201102062)资助

Association between human leukocyte antigenand nasopharyngeal-carcinoma

TANG Min-Zhong^1,2, CAI Yong-Lin², ZHENG Yu-Ming², ZENG Yi^1,3

1. College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, China 2. Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou Red Cross Hospital, Wuzhou 543002, China 3. State Key Laboratory for Infectious Diseases Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China

Received:2012-03-23 Revised:2012-04-24 Online:2012-12-20 Published:2012-12-25

摘要/Abstract

摘要： 鼻咽癌是一种多因素影响的复杂性疾病, 其发病具有显著的地理分布差异。Epstein-Barr(EB)病毒感染与鼻咽癌发病密切相关已得到公认, 但环境因素及遗传因素在鼻咽癌的发病中也具有重要作用。在鼻咽癌的遗传相关因素中, 位于6号染色体上具有高度多态性的人类白细胞抗原(Human leukocyte antigen, HLA)与鼻咽癌发病风险相关在多个研究组中被报道。随着DNA测序技术的发展, 高分辨基因分型技术的应用, HLA新等位基因数目呈指数级的上升, 更多的HLA全基因序列被研究者所报道。近年来, 等位基因关联性分析、微卫星连锁不平衡分析及全基因组关联性分析的研究结果均证实了6号染色体HLA区域与鼻咽癌具有显著关联。为了进一步探讨遗传相关性因子HLA在鼻咽癌发生发展中的作用, 文章着重综述了HLA与鼻咽癌相关性研究的最新进展, 为鼻咽癌HLA相关性研究提供新的思路。

关键词: 鼻咽癌, 人类白细胞抗原, 多态性, 相关性研究

Abstract: Nasopharyngeal carcinoma (NPC) is characterized by its distinct racial and geographical distribution with a multifactorial etiology. It has been well accepted that NPC is related to Epstein-Barr(EB) virus infection but environmental and genetics factors also play critical roles. Among host genetic markers associated with NPC, the highly variable class I human leukocyte antigen (HLA) genes on chromosome 6 (6p21.3) have shown a strong and consistent association with NPC risk. As the consequence of new generation DNA sequencing technologies used in HLA genotyping, the number of the reported HLA new alleles is dramaticllyincreasing, and more full length sequences of HLA alleles have been reported. The significant association between HLA genes and NPC has been identifiedin a series of studies, including HLA association study, linkage disequilibrium study for microsatellite markers, and genome wide association study. In this review, we summarize association studies between HLA and NPC to evaluate the role of genetic polymorphisms in NPC development and illustrate the new clues of HLA association for deepexploration.

Key words: nasopharyngeal carcinoma, HLA, polymorphism, association study

汤敏中，蔡永林，郑裕明，曾毅. 人类白细胞抗原与鼻咽癌的相关性[J]. 遗传, 2012, 34(12): 1505-1512.

TANG Min-Zhong CAI Yong-Lin ZHENG Yu-Ming ZENG Yi. Association between human leukocyte antigenand nasopharyngeal-carcinoma[J]. HEREDITAS, 2012, 34(12): 1505-1512.

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人类白细胞抗原与鼻咽癌的相关性

Association between human leukocyte antigenand nasopharyngeal-carcinoma

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