遗传 ›› 1996, Vol. 18 ›› Issue (4): 12-14.

• 论文 • 上一篇    下一篇

中国汉族人群原纤维蛋白-1基因(FBN1)第27内含子G/A多态性

陆振虞1; 陈仁彪1; 小林公子2; 李黎明2; 有波忠雄2; 滨口秀夫2 LU Zhen-Yu1;CHEN Ren-Biao1;K.Kobayashi2;LI Li-Ming2;T.Arinami2;H.Hamaguchi2   

  1. 1.上海第二医科大学医学遗传学教研室, 上海 200025 2.日本国筑波大学医学遗传学教研室,上海市200025 1.Department of Medical Genetics,Shanghai Second Medical University,Shanhai 200025 2.Department of Medical Genetics,Institute of Basic Medical Science,University of Tsukuba,Tsukuba,305 Japan
  • 收稿日期:1900-01-01 出版日期:1996-08-10 发布日期:1996-08-10

Study on G/A Polymorphisms in Intron27 of Fibrillin-1 Gene in Chinese Han Population

  • Received:1900-01-01 Online:1996-08-10 Published:1996-08-10

摘要: 采用PCR-ASO方法, 对日本筑波大学101名中国汉族留学人员的DNA样品进行了原纤维蛋白-1基因(FBN1)第27内含子G/A多态性测定。结果发现,A等位基因频率为0.5396,G等位基因频率为0.4604。与Tynan等人报道的数据(A和G等位基因的频率分别为0.1675和0.8325)相比,有非常显著差异(P<0 .01),提示两样本间有不同的遗传背景。
Abstract:The G/A polymorphisms in intron 27 of fibrillin-1 gene in 101 Chinese Hans who were studying and working in University of Tsukuba,Japan were analyzed with PCR-ASO method.The frequencies of A and G alleles,were 0.5396 and 0.4604 respectively.In a population sample reported by Tynan the frequency of A allele was 0.1675 that of G allele was 0.8325.The distribution of G/A polymorphism was significantly different between the two population sample(P<0.01),suggesting different genetic backgrounds.

关键词: FBN1 gene, ASO
Key words,
PCR, G/A多态性, FBN1基因, G-带, 大麦, 染色体, 染色粒

Key words: Barley Chromosome G-band Chromomere