遗传 ›› 2004, Vol. 26 ›› Issue (2): 244-248.

• 论文 • 上一篇    下一篇

关于组蛋白甲基化的研究

李 想 ; 张 飞 雄 LI Xiang1 ; ZHANG Fei-xiong2   

  1. 首都师范大学生物系,100037 Department of Biology, Capital Normal University, Beijing China ,100037
  • 收稿日期:1900-01-01 出版日期:2004-03-28 发布日期:2004-03-28

On The Research of Histone Methylation

  • Received:1900-01-01 Online:2004-03-28 Published:2004-03-28

摘要:

主要阐述了组蛋白甲基转移酶的类型,组蛋白H3中第9位赖氨酸甲基化与异染色质的形成、常染色体中基因表达的调控,以及与DNA甲基化之间的关系,说明了组蛋白甲基化与组蛋白乙酰化、磷酸化的相互关系, 指出组蛋白甲基化对维持细胞各种状态的平衡起到极其重要的作用。
Abstract: The types of histone methyltransferases, the relationship between methylation of Lysine 9 of H3 and the formation of heterochromatin, gene regulation in euchromatin, and that with DNA methylation, were mainly introduced. The interrelation between histone methylation and histone acetylation/phosphorylation was summarized. It is showed that histone methylation plays a very important role in maintaining the balance state of cell. The future research tendency of histone methylation was fantanstic.

关键词: 组蛋白甲基化, 组蛋白甲基转移酶, 组蛋白磷酸化, 组蛋白乙酰化, 基因表达
Key words