遗传 ›› 2014, Vol. 36 ›› Issue (3): 220-227.doi: 10.3724/SP.J.1005.2014.0220
张朝晖1,2, 康现江1, 穆淑梅1
收稿日期:2013-07-15
修回日期:2013-11-01
出版日期:2014-03-20
发布日期:2014-02-25
通讯作者:
康现江, 教授, 博士生导师, 研究方向：生殖生物学。E-mail: xjkang@hbu.edu.cn
E-mail:xjkang@hbu.edu.cn
作者简介:张朝晖, 副主任医师, 在读博士研究生, 研究方向：生殖生物学。Tel: 0312-2093283; E-mail: zhizhi199999@163.com
基金资助:国家自然科学基金项目(编号：312723095)资助
Zhaohui Zhang1,2, Xianjiang Kang1, Shumei Mu1
Received:2013-07-15
Revised:2013-11-01
Online:2014-03-20
Published:2014-02-25
摘要：
组蛋白磷酸化是组蛋白氨基酸残基的磷酸化修饰, 是一类重要的翻译后修饰, 与有丝分裂和减数分裂的染色质压缩、染色质功能调节、转录的激活与抑制、DNA损伤修复以及物质代谢等多种机制相关。文章对国内外近10年多种代表性生物精子发生(孢子形成)的相关文献进行总结, 论述了组蛋白磷酸化在精子发生中调控蛋白质作用因子的结合位点、调控减数分裂过程中的DNA复制与重组、保障正确的染色质重塑、对减数分裂后的成熟精子核的完全包装等重要功能。这些发现加深了人们对于组蛋白及其翻译后修饰在精子发生及分化中作用的理解。
张朝晖, 康现江, 穆淑梅. 组蛋白磷酸化修饰与精子发生[J]. 遗传, 2014, 36(3): 220-227.
Zhaohui Zhang, Xianjiang Kang, Shumei Mu. Histone phosphorylation and spermatogenesis[J]. HEREDITAS, 2014, 36(3): 220-227.
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