[1] Glaser S, Anastassiadis K, Stewart AF. Current issues in mouse genome engineering. Nat Genet, 2005, 37(11): 1187-1193.[2] Branda CS, Dymecki SM. Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice. Dev Cell, 2004, 6(1): 7-28.[3] Rajewsky K, Gu H, Kühn R, Betz UA, Müller W, Roes J, Schwenk F. Conditional gene targeting. J Clin Invest, 1996, 98(3): 600-603.[4] Schmidt-Supprian M, Rajewsky K. Vagaries of conditional gene targeting. Nat Immunol, 2007, 8(7): 665-668.[5] Matthaei KI. Genetically manipulated mice: a powerful tool with unsuspected caveats. J Physiol, 2007, 582(Pt 2): 481-488.[6] Holzenberger M, Lenzner C, Leneuve P, Zaoui R, Hamard G, Vaulont S, Bouc YL. Cre-mediated germline mosaicism: a method allowing rapid generation of several alleles of a target gene. Nucleic Acids Res, 2000, 28(21): E92.[7] Rickert RC, Roes J, Rajewsky K. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res, 1997, 25(6): 1317-1318.[8] Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet, 1999, 21(1): 70-71.[9] Tsien JZ, Chen DF, Gerber D, Tom C, Mercer EH, Ander-son DJ, Mayford M, Kandel ER, Tonegawa S. Subregion- and cell type-restricted gene knockout in mouse brain. Cell, 1996, 87(7): 1317-1326.[10] Akagi K, Sandig V, Vooijs M, Van der Valk M, Giovannini M, Strauss M, Berns A. Cre-mediated somatic site-specific recombination in mice. Nucleic Acids Res, 1997, 25(9): 1766-1773.[11] Zinyk DL, Mercer EH, Harris E, Anderson DJ, Joyner AL. Fate mapping of the mouse midbrain-hindbrain constriction using a site-specific recombination system. Curr Biol, 1998, 8(11): 665-668.[12] Mao X, Fujiwara Y, Orkin SH. Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc Natl Acad Sci USA, 1999, 96(9): 5037-5042.[13] Lobe CG, Koop KE, Kreppner W, Lomeli H, Gertsenstein M, Nagy A. Z/AP, a double reporter for Cre-mediated re-combination. Dev Biol, 1999, 208(2): 281-292.[14] Michael SK, Brennan J, Robertson EJ. Efficient gene-specific expression of Cre recombinase in the mouse embryo by targeted insertion of a novel IRES-Cre cassette into endogenous loci. Mech Dev, 1999, 85(1-2): 35-47.[15] Novak A, Guo CY, Yang WY, Nagy A, Lobe CG. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis, 2000, 28(3-4): 147-155.[16] Kawamoto S, Niwa H, Tashiro F, Sano S, Kondoh G, Ta-keda J, Tabayashi K, Miyazaki J. A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre-mediated recombination. FEBS Lett, 2000, 470(3): 263-268.[17] Mao XH, Fujiwara Y, Chapdelaine A, Yang HD, Orkin SH. Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain. Blood, 2001, 97(1): 324-326.[18] Huang ZJ, Yu W, Lovett C, Tonegawa S. Cre/loxP acti-vated neuronal markers in mouse neocortex and hippo-campus. Genesis, 2002, 32(3): 209-217.[19] Braz JM, Rico B, Basbaum AI. Transneuronal tracing of diverse CNS circuits by Cre-mediated induction of wheat germ agglutinin in transgenic mice. Proc Natl Acad Sci USA, 2002, 99(23): 15148-15153.[20] Vintersten K, Monetti C, Gertsenstein M, Zhang P, Laszlo L, Biechele S, Nagy A. Mouse in red: red fluorescent protein expression in mouse ES cells, embryos, and adult animals. Genesis, 2004, 40(4): 241-246.[21] Madisen L, Zwingman TA, Sunkin SM, Oh SW, Zariwala HA, Gu H, Ng LL, Palmiter RD, Hawrylycz MJ, Jones AR, Lein ES, Zeng HK. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci, 2010, 13(1): 133-140.[22] Badaloni A, Bonanomi D, A |