乳腺肿瘤干细胞在乳腺癌发生、发展及耐药中的作用

doi:10.16288/j.yczz.25-036

遗传 ›› 2025, Vol. 47 ›› Issue (10): 1099-1117.doi: 10.16288/j.yczz.25-036

乳腺肿瘤干细胞在乳腺癌发生、发展及耐药中的作用

张宏博¹(), 孙凤桂², 孙建伟¹, 汤琦³(), 张旭¹()

1.云南大学生命科学学院，生命科学中心，云南省细胞代谢与疾病重点实验室，昆明 650500
2.山东省寿光市人民医院听力筛查室，寿光 262700
3.昆明医科大学第三附属医院，昆明 650118

收稿日期:2025-02-11 修回日期:2025-05-26 出版日期:2025-10-20 发布日期:2025-05-28
通讯作者: 张旭，博士，讲师，研究方向：细胞生物学。E-mail: xuzhang@ynu.edu.cn;
汤琦，博士，副主任医师，研究方向：临床肿瘤生物学。E-mail: tangqi@kmmu.edu.cn
作者简介:张宏博，硕士研究生，专业方向：生物化学与分子生物学。E-mail: 2952448189@qq.com
基金资助:
国家自然科学基金(82273460);国家自然科学基金(32260167);云南大学科研创新项目(KC-24249003);云南大学科研创新项目(2024J0026)

The role and mechanism of cancer stem cells in breast carcinogenesis, progression and drug resistance

Hongbo Zhang¹(), Fenggui Sun², Jianwei Sun¹, Qi Tang³(), Xu Zhang¹()

1. Yunnan Key Laboratory of Cell Metabolism and Diseases, Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming 650500, China
2. Department of Hearing Screening Room, Shouguang People's Hospital of Shandong Province, Shouguang 262700, China
3. The Third Affiliated Hospital, Kunming Medical University, Kunming 650118, China

Received:2025-02-11 Revised:2025-05-26 Published:2025-10-20 Online:2025-05-28
Supported by:
National Natural Science Foundation of China(82273460);National Natural Science Foundation of China(32260167);Yunnan University Research Innovation Project(KC-24249003);Yunnan University Research Innovation Project(2024J0026)

摘要/Abstract

摘要：

乳腺肿瘤干细胞(breast cancer stem cells，BCSCs)是乳腺癌中具有干细胞特征的细胞亚群，具有自我更新、多向分化和高度的肿瘤驱动能力。研究表明，BCSCs在乳腺癌发生、发展及耐药过程中发挥着关键作用，因此深入揭示BCSCs的生物学特性与调控机制是突破乳腺癌治疗难题的重要途径。本综述系统总结了BCSCs表面标志物鉴定、与肿瘤复发与转移的关系、关键调控信号网络，以及其在耐药性中的作用机制，同时探讨了基于BCSCs异质性和动态调控节点的靶向治疗策略，展望了未来精准治疗乳腺癌的潜在方向，为相关药物研发提供理论支持和新颖依据。

关键词: 乳腺癌, 肿瘤干细胞, 肿瘤发生, 肿瘤转移, 肿瘤耐药

Abstract:

Breast cancer stem cells (BCSCs) represent a distinctive subpopulation within breast cancer that exhibit stem cell-like characteristics, including self-renewal capability and multipotent differentiation. They are recognized as the central drivers of tumor initiation, progression, metastasis, and drug resistance. In-depth investigation of BCSCs represents a crucial avenue for overcoming the current therapeutic limitations in breast cancer. This review comprehensively summarizes recent advances in BCSCs-related research, focusing on key areas such as surface marker identification, mechanisms underlying tumor recurrence and metastasis, core regulatory signaling networks, and therapy resistance. Furthermore, it discusses potential clinical strategies targeting BCSCs, and explores future directions for precision medicine based on hetogeneity and dynamic regulation of BCSCs. These insights provide important theoretical foundations for the development of targeted therapies against breast cancer.

Key words: breast cancer, cancer stem cells, carcinogenesis, metastasis, drug resistance

张宏博, 孙凤桂, 孙建伟, 汤琦, 张旭. 乳腺肿瘤干细胞在乳腺癌发生、发展及耐药中的作用[J]. 遗传, 2025, 47(10): 1099-1117.

Hongbo Zhang, Fenggui Sun, Jianwei Sun, Qi Tang, Xu Zhang. The role and mechanism of cancer stem cells in breast carcinogenesis, progression and drug resistance[J]. Hereditas(Beijing), 2025, 47(10): 1099-1117.

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乳腺肿瘤干细胞在乳腺癌发生、发展及耐药中的作用

The role and mechanism of cancer stem cells in breast carcinogenesis, progression and drug resistance

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