核糖体DNA转录的表观调控与肿瘤发生

doi:10.16288/j.yczz.18-244

遗传 ›› 2019, Vol. 41 ›› Issue (3): 185-192.doi: 10.16288/j.yczz.18-244

• 综述 • 下一篇

核糖体DNA转录的表观调控与肿瘤发生

程香荣,胡兴琳,姜琦,黄星卫,王楠,雷蕾()

哈尔滨医科大学组织学与胚胎学教研室,哈尔滨 150081

收稿日期:2018-10-15 修回日期:2019-01-15 出版日期:2019-02-25 发布日期:2019-02-18
通讯作者: 雷蕾 E-mail:leiys2002@yahoo.com
作者简介:程香荣,在读硕士研究生,专业方向：基础医学。E-mail: xiangrongcheng@foxmail.com
基金资助:
国家自然科学基金项目(No. 31671545)

The epigenetic regulation of ribosomal DNA and tumorigenesis

Xiangrong Cheng,Xinglin Hu,Qi Jiang,Xingwei Huang,Nan Wang,Lei Lei()

Department of Histology and Embryology, Harbin Medical University, Harbin 150081, China

Received:2018-10-15 Revised:2019-01-15 Online:2019-02-25 Published:2019-02-18
Contact: Lei Lei E-mail:leiys2002@yahoo.com
Supported by:
Supported by the National Natural Science Foundation of China(No. 31671545)

摘要/Abstract

摘要：

近年来,表观遗传机制的研究结果提示核糖体DNA (rDNA)表观调控机制的缺陷可能诱导肿瘤发生。ATRX/DAXX复合物通过介导H3.3的H3K9me3修饰,建立和维持rDNA转录沉默。ATRX/DAXX基因在部分肿瘤中经常发生突变,可能刺激rDNA转录而促进肿瘤发生发展。本文主要阐述rDNA转录表达异常对肿瘤发生的促进作用,介绍rDNA基因转录的表观遗传调控机制,以期为针对rDNA转录调控机制的药物研发提供新的理论支持。

关键词: rDNA, 表观调控, H3.3, ATRX/DAXX, 肿瘤发生

Abstract:

Recent research in epigenetics suggests that defects in epigenetic regulation of ribosomal DNA (rDNA) transcription may contribute to tumorigenesis. ATRX/DAXX complex is involved in the establishment and maintenance of the silence of the rDNA gene through H3K9me3 modification at histone variant H3.3. The ATRX/DAXX-related genes are frequently mutated in some types of tumors, which may increase rDNA transcription and promote cancer development and progression. In this review, we focus on the mechanism that abnormal transcription of rDNA potentially influences tumorigenesis. We also summarize the epigenetic regulatory mechanism of rDNA transcription, which may provide new theoretical support for drug development based on rDNA transcriptional regulation.

Key words: rDNA, epigenetic regulation, H3.3, ATRX/DAXX, tumorigenesis

程香荣,胡兴琳,姜琦,黄星卫,王楠,雷蕾. 核糖体DNA转录的表观调控与肿瘤发生[J]. 遗传, 2019, 41(3): 185-192.

Xiangrong Cheng,Xinglin Hu,Qi Jiang,Xingwei Huang,Nan Wang,Lei Lei. The epigenetic regulation of ribosomal DNA and tumorigenesis[J]. Hereditas(Beijing), 2019, 41(3): 185-192.

参考文献

[1]	De Keersmaecker K, Sulima SO, Dinman JD . Ribosomopathies and the paradox of cellular hypo- to hyperproliferation. Blood, 2015,125(9):1377-1382.
[2]	Ruggero D, Pandolfi PP . Does the ribosome translate cancer? Nat Rev Cancer, 2003,3(3):179-192.
[3]	Sulima SO, Hofman IJF, De Keersmaecker K, Dinman JD . How ribosomes translate cancer. Cancer Discov, 2017,7(10):1069-1087.
[4]	Kopp K, Gasiorowski JZ, Chen D, Gilmore R, Norton JT, Wang C, Leary DJ, Chan EK, Dean DA, Huang S . Pol I transcription and pre-rRNA processing are coordinated in a transcription-dependent manner in mammalian cells. Mol Biol Cell, 2007,18(2):394-403.
[5]	Cheng XR, Wei YJ, Huang XW, Wang N, Jiang Q, Liu H, Lei L . Research progress on epigenetic regulation of rDNA transcription. Progress in Biochemistry and Biophysics, 2018,45(5):485-493.
[5]	程香荣, 魏艳军, 黄星卫, 王楠, 姜琦, 刘惠, 雷蕾 . 表观调控rDNA转录的研究进展. 生物化学与生物物理进展, 2018,45(5):485-493.
[6]	Grummt I . Wisely chosen paths--regulation of rRNA synthesis: delivered on 30 june 2010 at the 35th FEBS congress in gothenburg, sweden. The FEBS Journal, 2010,277(22):4626-4639.
[7]	Derenzini M, Montanaro L, Trerè D . Ribosome biogenesis and cancer. Acta Histochem, 2017,119(3):190-197.
[8]	Derenzini M . The AgNORs. Micron, 2000,31, 117-120.
[9]	McStay B, Grummt I . The epigenetics of rRNA genes: from molecular to chromosome biology. Annu Rev Cell Dev Bi, 2008,24, 131-157.
[10]	Xie W, Ling T, Zhou Y, Feng W, Zhu Q, Stunnenberg HG, Grummt I, Tao W . The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions. Proc Natl Acad Sci USA, 2012,109(21):8161-8166.
[11]	Xu X, Xiong X, Sun Y . The role of ribosomal proteins in the regulation of cell proliferation, tumorigenesis, and genomic integrity. Sci China Life Sci, 2016,59(7):656-672.
[12]	Warner JR , McIntosh KB. How common are extraribosomal functions of ribosomal proteins? Mol cell, 2009,34(1):3-11.
[13]	Zhou X, Liao JM, Liao WJ, Lu H . Scission of the p53-MDM2 Loop by ribosomal proteins. Genes Cancer, 2012,3(3-4):298-310.
[14]	de Las Heras-Rubio A, Perucho L, Paciucci R, Vilardell J, LLeonart ME . Ribosomal proteins as novel players in tumorigenesis. Cancer Metastasis Rev, 2014,33(1):115-141.
[15]	Thomas G . An encore for ribosome biogenesis in the control of cell proliferation. Nat Cell Biol, 2000,2(5):E71-72.

[1]	严程浩, 白韦钰, 张智猛, 沈俊岭, 王友军, 孙建伟. STIM1在肿瘤发生及转移中的研究进展[J]. 遗传, 2023, 45(5): 395-408.
[2]	常栋, 刘享享, 刘睿, 孙建伟. FSCN1在乳腺癌发生发展中的作用及其调控机制[J]. 遗传, 2023, 45(2): 115-127.
[3]	黄星卫, 程香荣, 王楠, 张雨薇, 廖辰, 金连弘, 雷蕾. 组蛋白H3变体H3.3及其在细胞重编程中的作用[J]. 遗传, 2018, 40(3): 186-196.
[4]	胡清霞,高昂,曾炜佳,王妍馨,董金堂,朱正茂. 高等哺乳动物LEM结构域蛋白家族的研究进展[J]. 遗传, 2015, 37(2): 128-139.
[5]	魏永永，侯静，唐文如，罗瑛. p53与Ras协同及其在肿瘤发生中的作用[J]. 遗传, 2012, 34(12): 1513-1521.
[6]	汤佳立，戚大石，张俞，刘慧娟，孙健英，曹清河，马代夫，李宗芸. 荧光原位杂交技术分析栽培种甘薯(Ipomoea batatas cv.Xushu No.18)染色体[J]. 遗传, 2010, 32(2): 177-182.
[7]	谢莉，韩永华，李冬郁，曾艳华. FISH分析栽培高粱×拟高粱、甜高粱×拟高粱的染色体行为[J]. 遗传, 2009, 31(4): 420-425.
[8]	张振武，安洋，滕春波. miR-17-92基因簇microRNAs对哺乳动物器官发育及肿瘤发生的调控[J]. 遗传, 2009, 31(11): 1094-1100.
[9]	徐川梅，别同德，王春梅，周波，陈佩度. 45S rDNA在小麦及其近缘物种染色体上的分布[J]. 遗传, 2007, 29(9): 1126-1130.
[10]	徐延浩，杨飞，程有林，马璐，王建波，李立家. 45S rDNA和5S rDNA在南瓜、丝瓜和冬瓜染色体上的比较定位[J]. 遗传, 2007, 29(5): 614-614―620.
[11]	廖进秋，杨瑞武，周永红，辻本壽. 波兰小麦和矮兰麦45S rDNA和5S rDNA基因位点FISH分析[J]. 遗传, 2007, 29(4): 449-454.
[12]	徐晓红，吴敏，张会斌，刘志虎. 嗜盐古生菌br基因的遗传分析[J]. 遗传, 2007, 29(3): 376-376―380.
[13]	吴易阳李岭. MicroRNA与肿瘤相关的信号转导通路[J]. 遗传, 2007, 29(12): 1419-1428.
[14]	兰添颖，刘博，董凤平，陈瑞阳，李秀兰，陈成彬. 菠菜rDNA及端粒多色荧光原位杂交分析[J]. 遗传, 2007, 29(11): 1405-1405―1408.
[15]	侯卫国，连宾. 慢生根瘤菌属结瘤基因的进化及遗传分析[J]. 遗传, 2007, 29(1): 118-118―126.

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

核糖体DNA转录的表观调控与肿瘤发生

The epigenetic regulation of ribosomal DNA and tumorigenesis

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

编辑推荐

Metrics