遗传 ›› 1997, Vol. 19 ›› Issue (4): 18-21.

• 论文 • 上一篇    下一篇

近交系NJS小鼠的育种及其特性研究

孙敬方 SUN Jing-Fang   

  1. 中国人民解放军南京军区南京总医院动物实验科, 南京 210002 Medical Animal Experimental Center of Nanjing Unit,PLA,Nanjing 210002
  • 收稿日期:1900-01-01 出版日期:1997-08-10 发布日期:1997-08-10

Studies on Breeding of Inbred NJS Mouse Strain and Its Specific Property

  • Received:1900-01-01 Online:1997-08-10 Published:1997-08-10

摘要: 近交系NJS小鼠是通过连续全同胞交配和在固定的普通日粮下以70日龄血清胆固醇含量为选育指标定向选育而成,经多项遗传监测证实已符合近交系动物的纯度要求,并具有独特的遗传概貌和特性。近交20世代后,该品系血清胆固醇含量为5.65±0.83mmol/L, 已超过小鼠的正常值范围,显示该品系小鼠已呈自发性高胆固醇血症状态。该品系8-10月龄动脉硬化在好发部位,如主动脉窦、升主动脉的阳性检出率为100%,主要是处于脂斑和脂纹期的病变。该品系可作为自发性高胆固醇血症和动脉粥样硬化症的模型动物。
Abstract:Inbred NJS mouse strain was bred by using continuous brother-sister mating and directive breeding on the common diet with serum cholesterol at 70 days as breeding index,Acording to various genetic monitoring,the strain has been bred as a standard inbred strain of mice in genetic homogeneity,with particular genetic system and specific property.After 20th generation,serum cholesterol of the strain was 5.65±0.83 mmol/L.This value went outside the normal range in mice showing that the strain was in a situation of spontaneous hypercholesterolemia.Its incidence of atheroscerosis was 100% in some liable positions such as aortic sac and ascending aorta at 8~10 months.Most of the pathological changes were in fatty streaks.The strain may be used as a animal model of spontaneous hypercholesterolemia and atherosclerosis.

关键词: 胆固醇, 动脉粥样硬化症
Key words,
自发性高胆固醇血症, 小鼠, 近交系, 白粉病抗性, 小麦, 生化标记, 染色体定位, 1BL·1RS易位系, 抗性抑制基因

Key words: Chromosomal location, Erysiphe graminis.f.sp., Genetic marker, Powdery mildew, Resistance suppressor, Triticum aestivum, 1BL.1RS translocation