遗传 ›› 2018, Vol. 40 ›› Issue (12): 1066-1074.doi: 10.16288/j.yczz.18-133

• 综述 • 上一篇    下一篇

秀丽隐杆线虫固有免疫功能神经调控机制研究进展

张秀妹1,高洁1,陈春红1,2,涂海军1,2()   

  1. 1. 湖南大学生物学院神经科学研究所,长沙 410082
    2. 湖南大学深圳研究院,深圳 518000
  • 收稿日期:2018-05-15 修回日期:2018-06-26 出版日期:2018-12-20 发布日期:2018-09-11
  • 通讯作者: 涂海军 E-mail:haijuntu@hnu.edu.cn
  • 作者简介:张秀妹,硕士研究生,专业方向：生物技术。E-mail: 1746504690@qq.com|高洁,硕士研究生,专业方向：生物医学工程。E-mail: 864133633@qq.com, 张秀妹和高洁并列第一作者。
  • 基金资助:
    国家自然科学基金项目(31540020);国家自然科学基金项目(31671048);深圳市科技创新委员会科技项目(JCYJ20160530192506314);湖南省自然科学基金项目(2017JJ2041)

Progress in the mechanisms of neural modulation of innate immunity in Caenorhabditis elegans

Xiumei Zhang1,Jie Gao1,Chunhong Chen1,2,Haijun Tu1,2()   

  1. 1. Institute of Neuroscience, College of Biology, Hunan University, Changsha 410082, China
    2. Shenzhen Research Institute, Hunan University, Shenzhen 518000, China
  • Received:2018-05-15 Revised:2018-06-26 Online:2018-12-20 Published:2018-09-11
  • Contact: Tu Haijun E-mail:haijuntu@hnu.edu.cn
  • Supported by:
    Supported by the National Natural Science Foundation of China(31540020);Supported by the National Natural Science Foundation of China(31671048);the Free Exploration Foundation of Shenzhen Science and Technology Innovation Committee(JCYJ20160530192506314);the Provincial Natural Science Foundation of Hunan Province(2017JJ2041)

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摘要：

固有免疫系统是动植物个体应对外来微生物侵入感染时非常重要的抵御防线。秀丽隐杆线虫(Caenorhabditis elegans,简称线虫)作为研究宿主与病原菌之间相互作用的经典模式动物,近年来在神经和免疫之间相互作用的分子与遗传机制等方面的研究取得了长足进展。研究表明,线虫神经元通过释放神经递质与神经多肽(如多巴胺、NLP-20)等,激活相关信号通路途经,参与线虫对病原菌的识别、逃避、调节物理屏障防御能力和激活固有免疫反应,并表达分泌抗菌肽以清除病原菌等的调控进程。本文综述了线虫神经系统调控固有免疫功能机制的最新研究进展,为人们深入了解神经与免疫系统间相互作用的功能分子及其调控机制和揭示人类神经与免疫系统相关疾病的病理机理提供了重要信息。

关键词: 秀丽隐杆线虫, 神经元, 固有免疫, 神经递质, 抗菌肽

Abstract:

The innate immune system is an important defense barrier against invasive microbial threats in plants and animals. The nematode worm Caenorhabditis elegans is a classic model to investigate the genetic and cellular mechanisms of the interaction between host and pathogens. In the past years, many studies have elucidated the machinery of host-pathogen interactions using C. elegans. Neurons secrete/release neuropeptides and neurotransmitters such as NLP-20 and dopamine, which in turn mediate microbial recognition, promote pathogen avoidance, activate innate immune response signaling to stimulate antimicrobial peptide expression and kill microbes, and ultimately protect organisms from pathogen infection. In this review, we summarize the recent advances in the mechanisms of neural modulation of innate immunity in C. elegans, which provide important knowledge not only for machinery of functional interaction between nervous and immune system, but also for pathological mechanisms of nervous and immune system related diseases.

Key words: Caenorhabditis elegans, neuron, innate immunity, neurotransmitter, antimicrobial peptide